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rufy3 RUN and FYVE domain containing 3 [ Danio rerio (zebrafish) ]

Gene ID: 541522, updated on 14-Nov-2024

Summary

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Official Symbol
rufy3provided by ZNC
Official Full Name
RUN and FYVE domain containing 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-050327-58
See related
Ensembl:ENSDARG00000029692 AllianceGenome:ZFIN:ZDB-GENE-050327-58
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7148884; wu:fj64d11; zgc:110543
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in regulation of axonogenesis. Predicted to be active in cytoplasm. Is expressed in nervous system and trigeminal placode. Orthologous to human RUFY3 (RUN and FYVE domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See rufy3 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (42907631..42940840)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (42307446..42340670)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene chemokine (C-X-C motif) ligand 11, duplicate 1 Neighboring gene uncharacterized LOC101886481 Neighboring gene chemokine (C-X-C motif) ligand 20 Neighboring gene G-rich RNA sequence binding factor 1 Neighboring gene MOB kinase activator 1Ba

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Unilateral dampening of Bmp activity by nodal generates cardiac left-right asymmetry. Veerkamp J, et al. Dev Cell, 2013 Mar 25. PMID 23499359
  2. Shutdown corner, a large deletion mutant isolated from a haploid mutagenesis screen in zebrafish. Casey MA, et al. G3 (Bethesda), 2022 Mar 4. PMID 35079792, Free PMC Article
  3. Many genes in fish have species-specific asymmetric rates of molecular evolution. Steinke D, et al. BMC Genomics, 2006 Feb 8. PMID 16466575, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC158578

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein RUFY3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014335.2 → NP_001014357.1  protein RUFY3

    See identical proteins and their annotated locations for NP_001014357.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091902
    UniProtKB/TrEMBL
    Q58EH3
    Related
    ENSDARP00000039972.4, ENSDART00000039973.6
    Conserved Domains (2) summary
    pfam02759
    Location:103 → 226
    RUN; RUN domain
    pfam10212
    Location:274 → 318
    TTKRSYEDQ; Predicted coiled-coil domain-containing protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    42907631..42940840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009301649.4 → XP_009299924.1  protein RUFY3 isoform X1

    UniProtKB/TrEMBL
    A0A8M3ASM9
    Conserved Domains (3) summary
    cd15744
    Location:607 → 656
    FYVE_RUFY3; FYVE-related domain found in RUN and FYVE domain-containing protein 3 (RUFY3) and similar proteins
    pfam02759
    Location:135 → 258
    RUN; RUN domain
    pfam10212
    Location:306 → 350
    TTKRSYEDQ; Predicted coiled-coil domain-containing protein

  2. XM_068221168.1 → XP_068077269.1  protein RUFY3 isoform X4

  3. XM_005165309.5 → XP_005165366.1  protein RUFY3 isoform X5

    UniProtKB/TrEMBL
    A0A8M2BCS2
    Conserved Domains (2) summary
    pfam02759
    Location:135 → 258
    RUN; RUN domain
    pfam10212
    Location:306 → 350
    TTKRSYEDQ; Predicted coiled-coil domain-containing protein

  4. XM_021476146.2 → XP_021331821.1  protein RUFY3 isoform X2

    UniProtKB/TrEMBL
    A0A8M9Q8K7
    Conserved Domains (3) summary
    cd15744
    Location:595 → 644
    FYVE_RUFY3; FYVE-related domain found in RUN and FYVE domain-containing protein 3 (RUFY3) and similar proteins
    pfam02759
    Location:123 → 244
    RUN; RUN domain
    cl25732
    Location:277 → 567
    SMC_N; RecF/RecN/SMC N terminal domain

  5. XM_009301650.4 → XP_009299925.1  protein RUFY3 isoform X3

    UniProtKB/TrEMBL
    A0A8M3B2N7
    Conserved Domains (3) summary
    cd15744
    Location:575 → 624
    FYVE_RUFY3; FYVE-related domain found in RUN and FYVE domain-containing protein 3 (RUFY3) and similar proteins
    pfam02759
    Location:103 → 226
    RUN; RUN domain
    pfam10212
    Location:274 → 318
    TTKRSYEDQ; Predicted coiled-coil domain-containing protein

  6. XM_021476147.2 → XP_021331822.1  protein RUFY3 isoform X6

    UniProtKB/TrEMBL
    A0A8M9PK32
    Conserved Domains (2) summary
    pfam02759
    Location:123 → 244
    RUN; RUN domain
    cl25732
    Location:277 → 490
    SMC_N; RecF/RecN/SMC N terminal domain
Nucleotide Protein Strain
Heading Accession and Version

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