Rnase2b ribonuclease, RNase A family, 2B (liver, eosinophil-derived neurotoxin) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rnase2bprovided by MGI
Official Full Name: ribonuclease, RNase A family, 2B (liver, eosinophil-derived neurotoxin)provided by MGI
Primary source: MGI:MGI:1858598
See related: Ensembl:ENSMUSG00000059606 AllianceGenome:MGI:1858598
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mR5; Ear5; Raf4
Summary: Predicted to enable RNA nuclease activity and lipopolysaccharide binding activity. Predicted to be involved in chemotaxis; defense response to Gram-positive bacterium; and innate immune response in mucosa. Predicted to be active in extracellular space. Orthologous to several human genes including RNASE2 (ribonuclease A family member 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

Location:: 14 C1; 14 26.4 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (51399717..51400475)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (51162260..51163018)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional activity of four mouse eosinophil associated ribonucleases, mEAR2, mEAR5, mEAR7 and mEAR11.
Title: Mouse eosinophil associated ribonucleases: Mechanism of cytotoxic, antibacterial and antiparasitic activities.
two novel lncRNAs, FMR5 and FMR6, are differentially expressed in Fragile X syndrome and Fragile X-associated tremor/ataxia syndrome
Title: Comprehensive analysis of the transcriptional landscape of the human FMR1 gene reveals two new long noncoding RNAs differentially expressed in Fragile X syndrome and Fragile X-associated tremor/ataxia syndrome.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:490507

NoName (e-PCR)
- UniSTS:488988

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA nuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA nuclease activity	ISO Inferred from Sequence Orthology more info
enables lipopolysaccharide binding	ISO Inferred from Sequence Orthology more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables ribonuclease A activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response in mucosa	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ribonuclease 2B

Names: MR-5; eosinophil cationic-type ribonuclease 5; eosinophil-associated ribonuclease 5; eosinophil-associated, ribonuclease A family, member 5; murine ribonuclease 5; ribonuclease A f4

NP_062271.2

EC 4.6.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019398.2 → NP_062271.2 ribonuclease 2B precursor

Status: VALIDATED

Source sequence(s)

AC163664

Consensus CDS

CCDS27039.1

UniProtKB/Swiss-Prot

O35292, Q8K416

UniProtKB/TrEMBL

Q0VDV3, W0UVC5

Related

ENSMUSP00000075074.4, ENSMUST00000075648.4

Conserved Domains (1) summary

pfam00074
Location:29 → 152

RnaseA; Pancreatic ribonuclease