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Cacng6 calcium channel, voltage-dependent, gamma subunit 6 [ Mus musculus (house mouse) ]

Gene ID: 54378, updated on 9-Dec-2024

Summary

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Official Symbol
Cacng6provided by MGI
Official Full Name
calcium channel, voltage-dependent, gamma subunit 6provided by MGI
Primary source
MGI:MGI:1859168
See related
Ensembl:ENSMUSG00000078815 AllianceGenome:MGI:1859168
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310033H20Rik
Summary
Predicted to enable calcium channel regulator activity. Predicted to be involved in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel. Predicted to be part of L-type voltage-gated calcium channel complex. Is expressed in central nervous system; heart; and retina. Human ortholog(s) of this gene implicated in aspirin-induced respiratory disease. Orthologous to human CACNG6 (calcium voltage-gated channel auxiliary subunit gamma 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in mammary gland adult (RPKM 5.5), limb E14.5 (RPKM 2.1) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Cacng6 in Genome Data Viewer
Location:
7 A1; 7 2.0 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (3472017..3484183)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (3423588..3435667)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, gamma subunit 8 Neighboring gene RIKEN cDNA 3300002P13 gene Neighboring gene microRNA 935 Neighboring gene STARR-seq mESC enhancer starr_17905 Neighboring gene predicted gene, 35037 Neighboring gene predicted gene, 45920 Neighboring gene STARR-seq mESC enhancer starr_17907 Neighboring gene T cell-interacting, activating receptor on myeloid cells 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A family of gamma-like calcium channel subunits. Klugbauer N, et al. FEBS Lett, 2000 Mar 24. PMID 10734232
  2. A cluster of three novel Ca2+ channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family. Burgess DL, et al. Genomics, 2001 Feb 1. PMID 11170751
  3. Calcium channel gamma subunits provide insights into the evolution of this gene family. Chu PJ, et al. Gene, 2001 Dec 12. PMID 11738816
  4. Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas. Templin JS, et al. Brain Res, 2012 May 31. PMID 22534482, Free PMC Article
  5. Lem2 is essential for cardiac development by maintaining nuclear integrity. Ross JA, et al. Cardiovasc Res, 2023 Sep 5. PMID 37067297, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study demonistrated that Cacng6 gene expression in mouse dorsal raphe nucleus
    Title: Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC144251, MGC144252, 2310033H20Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables calcium channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of L-type voltage-gated calcium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of L-type voltage-gated calcium channel complex ISO
Inferred from Sequence Orthology
more info
  
part_of L-type voltage-gated calcium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
voltage-dependent calcium channel gamma-6 subunit
Names
neuronal voltage-gated calcium channel gamma-6 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133183.2 → NP_573446.1  voltage-dependent calcium channel gamma-6 subunit

    See identical proteins and their annotated locations for NP_573446.1

    Status: VALIDATED

    Source sequence(s)
    AC217111
    Consensus CDS
    CCDS39726.1
    UniProtKB/Swiss-Prot
    Q8VHW3
    UniProtKB/TrEMBL
    Q14C42, Q14C43
    Related
    ENSMUSP00000138622.2, ENSMUST00000183200.8
    Conserved Domains (1) summary
    cl21598
    Location:47 → 223
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    3472017..3484183
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540200.4 → XP_006540263.1  voltage-dependent calcium channel gamma-6 subunit isoform X1

    See identical proteins and their annotated locations for XP_006540263.1

    UniProtKB/TrEMBL
    A0A0A0MQD3, Q14C43
    Related
    ENSMUSP00000104287.3, ENSMUST00000108647.3
    Conserved Domains (1) summary
    cl21598
    Location:47 → 141
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

  2. XM_036153252.1 → XP_036009145.1  voltage-dependent calcium channel gamma-6 subunit isoform X2

    Conserved Domains (1) summary
    cl21598
    Location:47 → 181
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VHW3.1 GenPept UniProtKB/Swiss-Prot:Q8VHW3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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