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PIMREG PICALM interacting mitotic regulator [ Homo sapiens (human) ]

Gene ID: 54478, updated on 28-Oct-2024

Summary

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Official Symbol
PIMREGprovided by HGNC
Official Full Name
PICALM interacting mitotic regulatorprovided by HGNC
Primary source
HGNC:HGNC:25483
See related
Ensembl:ENSG00000129195 MIM:617611; AllianceGenome:HGNC:25483
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CATS; RCS1; FAM64A
Summary
Predicted to be involved in cell division. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in spleen (RPKM 1.3), small intestine (RPKM 0.7) and 19 other tissues See more
Orthologs
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Genomic context

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See PIMREG in Genome Data Viewer
Location:
17p13.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (6444455..6451469)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (6344181..6351199)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (6347775..6354789)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371509 Neighboring gene uncharacterized LOC107985017 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:6347155-6347733 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:6347797-6348024 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6350771-6351437 Neighboring gene aryl hydrocarbon receptor interacting protein like 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:6357121-6357839 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8075 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6360909-6361690 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6361691-6362472 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6367015-6367566 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6367567-6368118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6373134-6373634 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6374667-6375190 Neighboring gene PITPNM family member 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6377377-6377969 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6377970-6378561 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:6396251-6396752 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6400873-6401763 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6404362-6404908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6447205-6447705 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6452242-6452960 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6458140-6458786 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6471007-6471507 Neighboring gene KIAA0753 Neighboring gene RNA, 5S ribosomal pseudogene 435 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6540081-6540863 Neighboring gene uncharacterized LOC122526780 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6540864-6541645 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11584 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:6543558-6544439

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A bioinformatics analysis of the clinicopathological and prognostic significance of FAM64A mRNA expression in gynecological cancers. Zheng HC, et al. J Obstet Gynaecol, 2023 Dec. PMID 37227120
  2. Cell Cycle-Related FAM64A Could be Activated by TGF-β Signaling to Promote Glioma Progression. Fu M, et al. Cell Mol Neurobiol, 2023 Aug. PMID 37081231
  3. CATS (FAM64A) abnormal expression reduces clonogenicity of hematopoietic cells. Barbutti I, et al. Oncotarget, 2016 Oct 18. PMID 27588395, Free PMC Article
  4. Aberrant FAM64A mRNA expression is an independent predictor of poor survival in pancreatic cancer. Jiao Y, et al. PLoS One, 2019. PMID 30695070, Free PMC Article
  5. Up-regulation of FAM64A promotes epithelial-to-mesenchymal transition and enhances stemness features in breast cancer cells. Zhang J, et al. Biochem Biophys Res Commun, 2019 May 28. PMID 30979502

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cell Cycle-Related FAM64A Could be Activated by TGF-beta Signaling to Promote Glioma Progression.
    Title: Cell Cycle-Related FAM64A Could be Activated by TGF-β Signaling to Promote Glioma Progression.
  2. A bioinformatics analysis of the clinicopathological and prognostic significance of FAM64A mRNA expression in gynecological cancers.
    Title: A bioinformatics analysis of the clinicopathological and prognostic significance of FAM64A mRNA expression in gynecological cancers.
  3. Excessive activation of HOXB13/PIMREG axis promotes hepatocellular carcinoma progression and drug resistance.
    Title: Excessive activation of HOXB13/PIMREG axis promotes hepatocellular carcinoma progression and drug resistance.
  4. FAM64A is an androgen receptor-regulated feedback tumor promoter in prostate cancer.
    Title: FAM64A is an androgen receptor-regulated feedback tumor promoter in prostate cancer.
  5. Molecular pathogenesis of breast cancer: impact of miR-99a-5p and miR-99a-3p regulation on oncogenic genes.
    Title: Molecular pathogenesis of breast cancer: impact of miR-99a-5p and miR-99a-3p regulation on oncogenic genes.
  6. FAM64A: A Novel Oncogenic Target of Lung Adenocarcinoma Regulated by Both Strands of miR-99a (miR-99a-5p and miR-99a-3p).
    Title: FAM64A: A Novel Oncogenic Target of Lung Adenocarcinoma Regulated by Both Strands of miR-99a (miR-99a-5p and miR-99a-3p).
  7. High expression of FAM64A is associated with advanced clinical grade, metastasis and unfavorable prognosis in breast cancer. Over-expressing FAM64A promotes breast cancer cell proliferation and migration.
    Title: Up-regulation of FAM64A promotes epithelial-to-mesenchymal transition and enhances stemness features in breast cancer cells.
  8. FAM64A plays an important role in the proliferation and migration of breast cancer cells, which might serve as a potential target for breast cancer treatment.
    Title: Knockdown of FAM64A suppresses proliferation and migration of breast cancer cells.
  9. PIMREG promotes breast cancer aggressiveness via disrupting the NF-kappaB/IkappaBalpha negative feedback loop, which suggests that PIMREG might be a valuable prognostic factor and potential target for diagnosis and therapy of metastatic breast cancer.
    Title: Overexpression of PIMREG promotes breast cancer aggressiveness via constitutive activation of NF-κB signaling.
  10. Study provides evidence that high FAM64A mRNA expression is an independent risk factor for poor prognosis in pancreatic cancer.
    Title: Aberrant FAM64A mRNA expression is an independent predictor of poor survival in pancreatic cancer.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10156, FLJ10491

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
protein PIMREG
Names
CALM interacting protein expressed in thymus and spleen
CALM-interactor expressed in thymus and spleen
family with sequence similarity 64 member A
protein FAM64A
regulator of chromosome segregation 1
regulator of chromosome segregation protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195228.2 → NP_001182157.1  protein PIMREG isoform 2

    See identical proteins and their annotated locations for NP_001182157.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant A. The resulting protein (isoform 2) is longer and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC055872, BC005004
    Consensus CDS
    CCDS56016.1
    UniProtKB/Swiss-Prot
    Q96CT4, Q9BSJ6, Q9NVV1, Q9NWB5
    UniProtKB/TrEMBL
    A0A0S2Z5F0, I3L156
    Related
    ENSP00000250056.8, ENST00000250056.12
    Conserved Domains (1) summary
    pfam07326
    Location:1 → 232
    DUF1466; Protein of unknown function (DUF1466)

  2. NM_019013.3 → NP_061886.2  protein PIMREG isoform 1

    See identical proteins and their annotated locations for NP_061886.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AC055872, BC013966
    Consensus CDS
    CCDS32541.1
    UniProtKB/TrEMBL
    A0A0S2Z5C7, I3L156
    Related
    ENSP00000459235.1, ENST00000572447.6
    Conserved Domains (1) summary
    pfam07326
    Location:1 → 231
    DUF1466; Protein of unknown function (DUF1466)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    6444455..6451469
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047436310.1 → XP_047292266.1  protein PIMREG isoform X1

    UniProtKB/TrEMBL
    I3L419
    Related
    ENSP00000459597.1, ENST00000571373.5

  2. XM_047436311.1 → XP_047292267.1  protein PIMREG isoform X2

    UniProtKB/TrEMBL
    A0A0S2Z5C7
    Related
    ENSP00000458534.1, ENST00000576056.5

  3. XM_017024778.2 → XP_016880267.1  protein PIMREG isoform X3

  4. XM_047436312.1 → XP_047292268.1  protein PIMREG isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    6344181..6351199
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316530.1 → XP_054172505.1  protein PIMREG isoform X1

    UniProtKB/TrEMBL
    I3L419

  2. XM_054316531.1 → XP_054172506.1  protein PIMREG isoform X2

    UniProtKB/TrEMBL
    A0A0S2Z5C7

  3. XM_054316532.1 → XP_054172507.1  protein PIMREG isoform X3

  4. XM_054316533.1 → XP_054172508.1  protein PIMREG isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BSJ6.1 GenPept UniProtKB/Swiss-Prot:Q9BSJ6

Gene LinkOut

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