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NEURL1B neuralized E3 ubiquitin protein ligase 1B [ Homo sapiens (human) ]

Gene ID: 54492, updated on 4-Jan-2025

Summary

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Official Symbol
NEURL1Bprovided by HGNC
Official Full Name
neuralized E3 ubiquitin protein ligase 1Bprovided by HGNC
Primary source
HGNC:HGNC:35422
See related
Ensembl:ENSG00000214357 MIM:615893; AllianceGenome:HGNC:35422
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
neur2; NEURL3; RNF67B; hNeur2
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent endocytosis. Located in actin cytoskeleton and cytosol. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in fat (RPKM 15.4), colon (RPKM 11.9) and 23 other tissues See more
Orthologs
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Genomic context

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See NEURL1B in Genome Data Viewer
Location:
5q35.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (172641263..172691540)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (173181429..173231748)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (172068266..172118543)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377729 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172043624-172044540 Neighboring gene uncharacterized LOC107986478 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172049085-172049770 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172053253-172053907 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172057552-172058052 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16623 Neighboring gene translation machinery associated 7 homolog (S. cerevisiae) pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:172085818-172086812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23639 Neighboring gene microRNA 5003 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172104581-172105165 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:172110180-172110680 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:172110681-172111181 Neighboring gene uncharacterized LOC107986479 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16624 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23640 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23641 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172139792-172140399 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172141615-172142220 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172153656-172154156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172170835-172171336 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:172171337-172171836 Neighboring gene heart enhancer 25 Neighboring gene uncharacterized LOC101928093 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23642 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:172194940-172195132 Neighboring gene cyclin Q pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16625 Neighboring gene VISTA enhancer hs1828 Neighboring gene dual specificity phosphatase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Neuralized family member NEURL1 is a ubiquitin ligase for the cGMP-specific phosphodiesterase 9A. Taal K, et al. Sci Rep, 2019 May 8. PMID 31068605, Free PMC Article
  2. Neuralized-2: expression in human and rodents and interaction with Delta-like ligands. Rullinkov G, et al. Biochem Biophys Res Commun, 2009 Nov 20. PMID 19723503
  3. Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1. Song R, et al. J Biol Chem, 2006 Nov 24. PMID 17003037
  4. Genome-wide association studies and heritability estimates of body mass index related phenotypes in Bangladeshi adults. Scannell Bryan M, et al. PLoS One, 2014. PMID 25133637, Free PMC Article
  5. The DNA sequence and comparative analysis of human chromosome 5. Schmutz J, et al. Nature, 2004 Sep 16. PMID 15372022

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association studies and heritability estimates of body mass index related phenotypes in bangladeshi adults.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp761M1511

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase NEURL1B
Names
E3 ubiquitin-protein ligase NEURL3
RING-type E3 ubiquitin transferase NEURL1B
neuralized 2 alternative protein
neuralized homolog 1B
neuralized-2
neuralized-like protein 1B
neuralized-like protein 3
NP_001136123.1
NP_001295106.1
NP_001295107.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142651.3 → NP_001136123.1  E3 ubiquitin-protein ligase NEURL1B isoform hNEUR2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (hNEUR2).
    Source sequence(s)
    AC027309, AK026748, AK096661, CN267889, GQ414757, HY104395
    Consensus CDS
    CCDS47342.1
    UniProtKB/Swiss-Prot
    A8MQ27, C9DQJ5, C9DQJ6, C9DQJ7
    Related
    ENSP00000358815.5, ENST00000369800.6
    Conserved Domains (4) summary
    smart00588
    Location:40 → 159
    NEUZ; domain in neuralized proteins
    pfam07177
    Location:41 → 106
    Neuralized; Neuralized
    pfam13920
    Location:499 → 549
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    cl02614
    Location:40 → 189
    SPRY; SPRY domain

  2. NM_001308177.2 → NP_001295106.1  E3 ubiquitin-protein ligase NEURL1B isoform hNEUR2-deltaNHR1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (hNEUR2-deltaNHR1) that is shorter than isoform hNEUR2.
    Source sequence(s)
    AC027309, AK026748, AK096661, CN267889, GQ414758, HY104395
    Consensus CDS
    CCDS83042.1
    UniProtKB/Swiss-Prot
    A8MQ27
    Related
    ENSP00000430001.1, ENST00000522853.5
    Conserved Domains (3) summary
    smart00588
    Location:97 → 217
    NEUZ; domain in neuralized proteins
    pfam07177
    Location:100 → 165
    Neuralized; Neuralized
    pfam13920
    Location:317 → 367
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

  3. NM_001308178.2 → NP_001295107.1  E3 ubiquitin-protein ligase NEURL1B isoform hNEUR2-deltaNHR2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (hNEUR2-deltaNHR2) that is shorter than isoform hNEUR2.
    Source sequence(s)
    AC027309, AK026748, AK096661, CN267889, GQ414759, HY104395
    Consensus CDS
    CCDS78085.1
    UniProtKB/Swiss-Prot
    A8MQ27
    Related
    ENSP00000429797.1, ENST00000520919.5
    Conserved Domains (3) summary
    cd00162
    Location:263 → 302
    RING_Ubox; modified RING-HC finger (C3HC5-type) [structural motif]
    pfam07177
    Location:41 → 193
    Neuralized
    cl17238
    Location:262 → 304
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    172641263..172691540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    173181429..173231748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_015355.3: Suppressed sequence

    Description
    NR_015355.3: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8MQ27.1 GenPept UniProtKB/Swiss-Prot:A8MQ27

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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