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EPB41L4A-DT EPB41L4A divergent transcript [ Homo sapiens (human) ]

Gene ID: 54508, updated on 17-Sep-2024

Summary

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Official Symbol
EPB41L4A-DTprovided by HGNC
Official Full Name
EPB41L4A divergent transcriptprovided by HGNC
Primary source
HGNC:HGNC:25643
See related
Ensembl:ENSG00000278921 AllianceGenome:HGNC:25643
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EPB41L4A-AS2
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Genomic context

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See EPB41L4A-DT in Genome Data Viewer
Location:
5q22.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (112419583..112420978)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (112930025..112931420)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (111755280..111756675)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene erythrocyte membrane protein band 4.1 like 4A Neighboring gene uncharacterized LOC124901044 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:111553293-111553794 Neighboring gene uncharacterized LOC101927023 Neighboring gene NANOG hESC enhancer GRCh37_chr5:111573109-111573620 Neighboring gene NANOG hESC enhancer GRCh37_chr5:111665295-111665825 Neighboring gene Sharpr-MPRA regulatory region 6283 Neighboring gene MPRA-validated peak5419 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:111722519-111723020 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:111723021-111723520 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16236 Neighboring gene high mobility group box 3 pseudogene 16 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:111839317-111839816 Neighboring gene uncharacterized LOC124901043 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:111858695-111859196

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and validation a TGF-β-associated long non-coding RNA of head and neck squamous cell carcinoma by bioinformatics method. Huang T, et al. J Transl Med, 2018 Feb 28. PMID 29490660, Free PMC Article
  2. The long non-coding RNA EPB41L4A-AS2 inhibits tumor proliferation and is associated with favorable prognoses in breast cancer and other solid tumors. Xu S, et al. Oncotarget, 2016 Apr 12. PMID 26980733, Free PMC Article
  3. Long noncoding RNA EPB41L4A-AS2 inhibits hepatocellular carcinoma development by sponging miR-301a-5p and targeting FOXL1. Wang YG, et al. J Exp Clin Cancer Res, 2019 Apr 10. PMID 30971290, Free PMC Article
  4. Long non-coding RNA EPB41L4A-AS2 suppresses progression of ovarian cancer by sequestering microRNA-103a to upregulate transcription factor RUNX1T1. Sun T, et al. Exp Physiol, 2020 Jan. PMID 31645082
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Bennett EJ, et al. Cell, 2010 Dec 10. PMID 21145461, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long non-coding RNA EPB41L4A-AS2 suppresses progression of ovarian cancer by sequestering microRNA-103a to upregulate transcription factor RUNX1T1.
    Title: Long non-coding RNA EPB41L4A-AS2 suppresses progression of ovarian cancer by sequestering microRNA-103a to upregulate transcription factor RUNX1T1.
  2. FOXL1 and miR-301a-5p show opposite biological effects in cell proliferation and migration. miR-301a-5p overexpression rescued the EPB41L4A-AS2 upregulation induced depression in proliferation, migration and invasion of HCC cells, as well as promotion effect on FOXL1 expression. In vivo experiments proved that EPB41L4A-AS2 suppress tumor growth and extrahepatic metastasis (lung) via the miR-301a-5p-FOXL1 axis.
    Title: Long noncoding RNA EPB41L4A-AS2 inhibits hepatocellular carcinoma development by sponging miR-301a-5p and targeting FOXL1.
  3. The relationship of EPB41L4A-AS2 with the clinicopathological features and prognosis of head and neck squamous cell carcinoma patients was evaluated.
    Title: Identification and validation a TGF-β-associated long non-coding RNA of head and neck squamous cell carcinoma by bioinformatics method.
  4. Low EPB41L4A-AS2 expression is associated with breast, renal, and lung cancer.
    Title: The long non-coding RNA EPB41L4A-AS2 inhibits tumor proliferation and is associated with favorable prognoses in breast cancer and other solid tumors.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • EPB41L4A antisense RNA 2 (head to head)

Clone Names

  • FLJ11235

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_027706.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK002097, BX089466
    Related
    ENST00000623705.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    112419583..112420978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    112930025..112931420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_019033.1: Suppressed sequence

    Description
    NM_019033.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version

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