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Otud5 OTU domain containing 5 [ Mus musculus (house mouse) ]

Gene ID: 54644, updated on 9-Dec-2024

Summary

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Official Symbol
Otud5provided by MGI
Official Full Name
OTU domain containing 5provided by MGI
Primary source
MGI:MGI:1859615
See related
Ensembl:ENSMUSG00000031154 AllianceGenome:MGI:1859615
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DUBA; Sfc7; DXImx46e
Summary
Predicted to enable K48-linked deubiquitinase activity; K63-linked deubiquitinase activity; and cysteine-type deubiquitinase activity. Acts upstream of or within several processes, including alpha-beta T cell differentiation; negative regulation of interleukin-17 production; and regulation of T-helper 17 type immune response. Predicted to be located in nucleus. Orthologous to human OTUD5 (OTU deubiquitinase 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 21.1), spleen adult (RPKM 18.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Otud5 in Genome Data Viewer
Location:
X A1.1; X 3.54 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (7705852..7742861)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (7839613..7876626)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene GRIP1 associated protein 1 Neighboring gene microRNA 1198 Neighboring gene potassium voltage-gated channel, Shal-related family, member 1 Neighboring gene STARR-seq mESC enhancer starr_46674 Neighboring gene STARR-positive B cell enhancer ABC_E11045 Neighboring gene proviral integration site 2 Neighboring gene solute carrier family 35 (UDP-galactose transporter), member A2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Podocyte OTUD5 alleviates diabetic kidney disease through deubiquitinating TAK1 and reducing podocyte inflammation and injury. Zhao Y, et al. Nat Commun, 2024 Jun 27. PMID 38937512, Free PMC Article
  2. OTUD5 promotes the inflammatory immune response by enhancing MyD88 oligomerization and Myddosome formation. Liu Y, et al. Cell Death Differ, 2024 Jun. PMID 38605168, Free PMC Article
  3. USP11 Exacerbates Radiation-Induced Pneumonitis by Activating Endothelial Cell Inflammatory Response via OTUD5-STING Signaling. Tang Y, et al. Int J Radiat Oncol Biol Phys, 2024 Jul 15. PMID 38364946
  4. Hepatocyte Deubiquitinating Enzyme OTUD5 Deficiency is a Key Aggravator for Metabolic Dysfunction-Associated Steatohepatitis by Disturbing Mitochondrial Homeostasis. Dai J, et al. Cell Mol Gastroenterol Hepatol, 2024. PMID 38036082, Free PMC Article
  5. Phosphorylation-dependent activity of the deubiquitinase DUBA. Huang OW, et al. Nat Struct Mol Biol, 2012 Jan 15. PMID 22245969

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Podocyte OTUD5 alleviates diabetic kidney disease through deubiquitinating TAK1 and reducing podocyte inflammation and injury.
    Title: Podocyte OTUD5 alleviates diabetic kidney disease through deubiquitinating TAK1 and reducing podocyte inflammation and injury.
  2. USP11 Exacerbates Radiation-Induced Pneumonitis by Activating Endothelial Cell Inflammatory Response via OTUD5-STING Signaling.
    Title: USP11 Exacerbates Radiation-Induced Pneumonitis by Activating Endothelial Cell Inflammatory Response via OTUD5-STING Signaling.
  3. OTUD5 promotes the inflammatory immune response by enhancing MyD88 oligomerization and Myddosome formation.
    Title: OTUD5 promotes the inflammatory immune response by enhancing MyD88 oligomerization and Myddosome formation.
  4. Hepatocyte Deubiquitinating Enzyme OTUD5 Deficiency is a Key Aggravator for Metabolic Dysfunction-Associated Steatohepatitis by Disturbing Mitochondrial Homeostasis.
    Title: Hepatocyte Deubiquitinating Enzyme OTUD5 Deficiency is a Key Aggravator for Metabolic Dysfunction-Associated Steatohepatitis by Disturbing Mitochondrial Homeostasis.
  5. OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING.
    Title: OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING.
  6. OTUD5 cooperates with TRIM25 in transcriptional regulation and tumor progression via deubiquitination activity.
    Title: OTUD5 cooperates with TRIM25 in transcriptional regulation and tumor progression via deubiquitination activity.
  7. data identify DUBA as a cell-intrinsic suppressor of IL-17 production
    Title: Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ12550

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables K48-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables K48-linked deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables K63-linked deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables K63-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables K63-linked deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within CD8-positive, alpha-beta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within T-helper 17 cell lineage commitment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within interleukin-21 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within interleukin-9 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of interleukin-17 production IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of interleukin-17 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neural crest cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in neural crest cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TORC2 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TORC2 signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein K48-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked deubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein K63-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked deubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within protein deubiquitination ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within regulation of T-helper 17 type immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
involved_in response to lipopolysaccharide ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
OTU domain-containing protein 5
Names
deubiquinating enzyme A
deubiquitinating enzyme A
NP_001277465.1
NP_001277466.1
NP_001413225.1
NP_001413227.1
NP_613070.2
XP_006527728.1
XP_006527729.1
XP_030107258.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290536.2 → NP_001277465.1  OTU domain-containing protein 5 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 4 both encode the same isoform (1).
    Source sequence(s)
    AL671978, AL671995
    Consensus CDS
    CCDS72336.1
    UniProtKB/TrEMBL
    A2AES4, A2AES5
    Related
    ENSMUSP00000111330.2, ENSMUST00000115666.8
    Conserved Domains (1) summary
    cl19932
    Location:221 → 332
    OTU; OTU-like cysteine protease

  2. NM_001290537.2 → NP_001277466.1  OTU domain-containing protein 5 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame segment of the 5' coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AL671978, AL671995
    Consensus CDS
    CCDS72335.1
    UniProtKB/TrEMBL
    A2AES3
    Related
    ENSMUSP00000111332.4, ENSMUST00000115668.10
    Conserved Domains (1) summary
    cl19932
    Location:178 → 287
    OTU; OTU-like cysteine protease

  3. NM_001426296.1 → NP_001413225.1  OTU domain-containing protein 5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL671978, AL671995
    UniProtKB/TrEMBL
    A2AES4, A2AES5

  4. NM_001426298.1 → NP_001413227.1  OTU domain-containing protein 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL671978, AL671995
    UniProtKB/Swiss-Prot
    Q3U2S4, Q3UE33, Q91YL5, Q9CV50, Q9JIG6
    UniProtKB/TrEMBL
    A2AES4

  5. NM_138604.4 → NP_613070.2  OTU domain-containing protein 5 isoform 2

    See identical proteins and their annotated locations for NP_613070.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2 and 5 both encode the same isoform (2).
    Source sequence(s)
    AL671978, AL671995
    Consensus CDS
    CCDS29975.1
    UniProtKB/Swiss-Prot
    Q3U2S4, Q3UE33, Q91YL5, Q9CV50, Q9JIG6
    UniProtKB/TrEMBL
    A2AES4
    Related
    ENSMUSP00000033494.10, ENSMUST00000033494.16
    Conserved Domains (1) summary
    cl19932
    Location:221 → 332
    OTU; OTU-like cysteine protease

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    7705852..7742861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527666.4 → XP_006527729.1  OTU domain-containing protein 5 isoform X4

    UniProtKB/TrEMBL
    A2AES4
    Conserved Domains (1) summary
    cl19932
    Location:221 → 332
    OTU; OTU-like cysteine protease

  2. XM_006527665.5 → XP_006527728.1  OTU domain-containing protein 5 isoform X3

    UniProtKB/TrEMBL
    A2AES4
    Conserved Domains (1) summary
    cl19932
    Location:220 → 331
    OTU; OTU-like cysteine protease

  3. XM_030251398.2 → XP_030107258.1  OTU domain-containing protein 5 isoform X5

    UniProtKB/TrEMBL
    A2AES3
    Conserved Domains (1) summary
    cl19932
    Location:177 → 288
    OTU; OTU-like cysteine protease
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U2S4.2 GenPept UniProtKB/Swiss-Prot:Q3U2S4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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