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ZNF853 zinc finger protein 853 [ Homo sapiens (human) ]

Gene ID: 54753, updated on 2-Nov-2024

Summary

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Official Symbol
ZNF853provided by HGNC
Official Full Name
zinc finger protein 853provided by HGNC
Primary source
HGNC:HGNC:21767
See related
Ensembl:ENSG00000236609 AllianceGenome:HGNC:21767
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary (RPKM 5.7), brain (RPKM 5.5) and 23 other tissues See more
Orthologs
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Genomic context

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See ZNF853 in Genome Data Viewer
Location:
7p22.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (6615610..6624290)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (6734792..6743476)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (6655241..6663921)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene zinc finger DHHC-type palmitoyltransferase 4 Neighboring gene uncharacterized LOC124901582 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:6628794-6629632 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:6637314-6637506 Neighboring gene integrator complex subunit 15 Neighboring gene Sharpr-MPRA regulatory region 9377 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6653371-6654124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6654125-6654878 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6663565-6664065 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17956 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25632 Neighboring gene Sharpr-MPRA regulatory region 15225 Neighboring gene zinc finger protein 316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6698799-6699300 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:6703791-6704291 Neighboring gene uncharacterized LOC124901583

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks. Imbeault M, et al. Nature, 2017 Mar 23. PMID 28273063
  2. Cys2His2 zinc finger protein family: classification, functions, and major members. Razin SV, et al. Biochemistry (Mosc), 2012 Mar. PMID 22803940
  3. A quantitative atlas of mitotic phosphorylation. Dephoure N, et al. Proc Natl Acad Sci U S A, 2008 Aug 5. PMID 18669648, Free PMC Article
  4. The DNA sequence of human chromosome 7. Hillier LW, et al. Nature, 2003 Jul 10. PMID 12853948
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

Homology

Clone Names

  • DKFZp547K054, DKFZp434J1015

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 853

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001353546.2 → NP_001340475.1  zinc finger protein 853 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC073343, BG056932
    Conserved Domains (2) summary
    COG5048
    Location:469 → 600
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:500 → 520
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_017560.3 → NP_060030.1  zinc finger protein 853 isoform 1

    See identical proteins and their annotated locations for NP_060030.1

    Status: VALIDATED

    Source sequence(s)
    AC073343, BG056932
    Consensus CDS
    CCDS59048.1
    UniProtKB/Swiss-Prot
    P0CG23
    Related
    ENSP00000455585.1, ENST00000457543.4
    Conserved Domains (3) summary
    COG5048
    Location:484 → 615
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:515 → 535
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:583 → 608
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    6615610..6624290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515439.4 → XP_011513741.1  zinc finger protein 853 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:522 → 575
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:526 → 546
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:594 → 619
    zf-H2C2_2; Zinc-finger double domain

  2. XM_011515438.4 → XP_011513740.1  zinc finger protein 853 isoform X1

    Conserved Domains (3) summary
    COG5048
    Location:537 → 590
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:541 → 561
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:609 → 634
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    6734792..6743476
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358515.1 → XP_054214490.1  zinc finger protein 853 isoform X2

  2. XM_054358514.1 → XP_054214489.1  zinc finger protein 853 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CG23.1 GenPept UniProtKB/Swiss-Prot:P0CG23

Gene LinkOut

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