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PXK PX domain containing serine/threonine kinase like [ Homo sapiens (human) ]

Gene ID: 54899, updated on 14-Nov-2024

Summary

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Official Symbol
PXKprovided by HGNC
Official Full Name
PX domain containing serine/threonine kinase likeprovided by HGNC
Primary source
HGNC:HGNC:23326
See related
Ensembl:ENSG00000168297 MIM:611450; AllianceGenome:HGNC:23326
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLOB; MONAKA
Summary
This gene encodes a phox (PX) domain-containing protein which may be involved in synaptic transmission and the ligand-induced internalization and degradation of epidermal growth factors. Variations in this gene may be associated with susceptibility to systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Expression
Broad expression in thyroid (RPKM 17.1), brain (RPKM 11.4) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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See PXK in Genome Data Viewer
Location:
3p14.3
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (58332892..58426127)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (58373299..58466504)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (58318619..58411854)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:58222930-58223869 Neighboring gene abhydrolase domain containing 6, acylglycerol lipase Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:58276464-58277147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20007 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20008 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20009 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:58298051-58298552 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:58307710-58308471 Neighboring gene ribonuclease P/MRP subunit p14 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14488 Neighboring gene Sharpr-MPRA regulatory region 6112 Neighboring gene hydroxyacyl-thioester dehydratase type 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20010 Neighboring gene uncharacterized LOC105377106 Neighboring gene MPRA-validated peak4672 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr3:58363583-58363810 Neighboring gene WDR53 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:58383233-58383732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20011 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20012 Neighboring gene uncharacterized LOC107986092 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14489 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:58420577-58421186 Neighboring gene pyruvate dehydrogenase E1 subunit beta Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14490 Neighboring gene potassium channel tetramerization domain containing 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Polymorphisms of PXK are associated with autoantibody production, but not disease risk, of systemic lupus erythematosus in Chinese mainland population. Yu B, et al. Lupus, 2011 Jan. PMID 20829310
  2. Different genetic effect of PXK on systemic lupus erythematosus in the Korean population. Kim EM, et al. Rheumatol Int, 2012 Jan. PMID 21243490
  3. Expression pattern and subcellular localization of five splice isoforms of human PXK. Zou X, et al. Int J Mol Med, 2005 Oct. PMID 16142408
  4. PXK locus in systemic lupus erythematosus: fine mapping and functional analysis reveals novel susceptibility gene ABHD6. Oparina NY, et al. Ann Rheum Dis, 2015 Mar. PMID 24534757
  5. Associations between PXK and TYK2 polymorphisms and systemic lupus erythematosus: a meta-analysis. Lee YH, et al. Inflamm Res, 2012 Sep. PMID 22592861

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Telomere Length and Male Fertility.
    Title: Telomere Length and Male Fertility.
  2. First described as part of human kinome analysis, named Slob after Drosophila ortholog.
    Title: The mouse kinome: discovery and comparative genomics of all mouse protein kinases.
  3. Two of these kinases that were classified as resistors were PX domain-containing serine/threonine kinase (PXK) and AP2-associated kinase 1 (AAK1), which promote receptor endocytosis and may enable cells to resist TRAIL-induced apoptosis
    Title: Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
  4. genetic association study in Han population in China: Data suggest an SNP in PXK [rs2176082(C/T); but not rs6445975(G/T)] is associated with recurrent pregnancy loss; SNPs in KIAA0319L [rs2275247(A/G)] or JAZF1 [rs1635852(C/T)] are not associated.
    Title: Association between KIAA0319L, PXK and JAZF1 gene polymorphisms and unexplained recurrent pregnancy loss in Chinese Han couples.
  5. Results confirm the genetic association of the locus 3p14.3 with systemic lupus erythematosus in Europeans and point to the ABHD6 and not PXK, as the major susceptibility gene in the region.
    Title: PXK locus in systemic lupus erythematosus: fine mapping and functional analysis reveals novel susceptibility gene ABHD6.
  6. study determined that the previously described systemic lupus erythematosus susceptibility loci PXK (P = 3.27 x 10(-11), OR = 1.20) and JAZF1 (P = 1.11 x 10(-8), OR = 1.13) are shared with systemic sclerosis
    Title: A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
  7. The rs6445975 polymorphism of PXK and the rs2304256 polymorphism of tyrosine kinase 2 are associated with the development of systemic lupus erythematosus in Europeans
    Title: Associations between PXK and TYK2 polymorphisms and systemic lupus erythematosus: a meta-analysis.
  8. The association of PXK rs6445975 with systemic lupus erythematosus that was previously observed in Caucasians was not replicated in Koreans or in Hong Kong Chinese.
    Title: Different genetic effect of PXK on systemic lupus erythematosus in the Korean population.
  9. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
    Title: Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients.
  10. Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
    Title: Genetically determined Amerindian ancestry correlates with increased frequency of risk alleles for systemic lupus erythematosus.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
EBI GWAS Catalog
Discovery and refinement of loci associated with lipid levels.
EBI GWAS Catalog
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
EBI GWAS Catalog
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.
EBI GWAS Catalog
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20335

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables ATP binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables nucleotide binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
NOT enables protein kinase activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in modulation of chemical synaptic transmission ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of ATP-dependent activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of monoatomic ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
NOT involved_in protein phosphorylation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
PX domain-containing protein kinase-like protein
Names
PX ser/thr kinase v2
PX serine/threonine kinase
modulator of Na,K-ATPase long form

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289095.2 → NP_001276024.1  PX domain-containing protein kinase-like protein isoform b

    See identical proteins and their annotated locations for NP_001276024.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and contains an alternate exon in the 3' coding region, compared to variant 1. This results in a frameshift and an early stop codon, compared to variant 1. It encodes isoform b (also known as isoform 2), which is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK131385, AL137938, AY437879, DA296189
    Consensus CDS
    CCDS74954.1
    UniProtKB/TrEMBL
    A0A0C4DG95, B4DID9
    Related
    ENSP00000419049.1, ENST00000479241.5
    Conserved Domains (2) summary
    cd00180
    Location:181 → 328
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:13 → 115
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  2. NM_001289096.2 → NP_001276025.1  PX domain-containing protein kinase-like protein isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two consecutive, alternate, in-frame exons in the 5' coding region, compared to variant 1. It encodes isoform c (also known as isoform 3), which is shorter than isoform a.
    Source sequence(s)
    AL137938, AY274811, AY437879, BG613223, DA296189
    UniProtKB/TrEMBL
    B4DJS8
    Conserved Domains (2) summary
    cd00180
    Location:165 → 312
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:13 → 99
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  3. NM_001289098.2 → NP_001276027.1  PX domain-containing protein kinase-like protein isoform d

    See identical proteins and their annotated locations for NP_001276027.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in the 3' region, resulting in an early stop codon, compared to variant 1. It encodes isoform d (also known as isoform 4), which is shorter and has a distinct C-terminus, compared to isoform a. Variants 4 and 8 both encode the same isoform (d).
    Source sequence(s)
    AK131385, AK296034, AL137938, DQ124708, HY164612
    Consensus CDS
    CCDS74952.1
    UniProtKB/TrEMBL
    B4DID9
    Related
    ENSP00000373222.4, ENST00000383716.7
    Conserved Domains (3) summary
    cd06871
    Location:13 → 132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:186 → 492
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:198 → 345
    PKc; Catalytic domain of Protein Kinases

  4. NM_001289099.2 → NP_001276028.1  PX domain-containing protein kinase-like protein isoform e

    See identical proteins and their annotated locations for NP_001276028.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform e (also known as isoform 5), which has a shorter N-terminus, compared to isoform a. Variants 5 and 9 both encode the same isoform (e).
    Source sequence(s)
    AK131385, AL137938, AY847220, HY164612
    UniProtKB/TrEMBL
    B4DJS8
    Conserved Domains (3) summary
    cd22062
    Location:462 → 492
    WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
    cl02563
    Location:1 → 49
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl21453
    Location:115 → 262
    PKc_like; Protein Kinases, catalytic domain

  5. NM_001289100.2 → NP_001276029.1  PX domain-containing protein kinase-like protein isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks two consecutive, alternate, in-frame exons in the 5' coding region and contains an alternate exon in the 3' region, resulting in an early stop codon, compared to variant 1. It encodes isoform f (also known as isoform 6), which is shorter and has a distinct C-terminus, compared to isoform a. Variants 6 and 10 both encode the same isoform (f).
    Source sequence(s)
    AK295542, AK296034, AL137938, AY274811, DA296189
    Consensus CDS
    CCDS74955.1
    UniProtKB/TrEMBL
    B4DID9, E9PD56
    Related
    ENSP00000417903.1, ENST00000463280.5
    Conserved Domains (3) summary
    COG0515
    Location:153 → 459
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:165 → 312
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:13 → 99
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  6. NM_001289101.2 → NP_001276030.1  PX domain-containing protein kinase-like protein isoform g

    See identical proteins and their annotated locations for NP_001276030.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform g (also known as isoform 7), which is shorter at the N-terminus, compared to isoform a. Variants 7 and 11 both encode the same isoform (g).
    Source sequence(s)
    AK131385, AK296215, AL137938, AY274811, DA296189
    UniProtKB/TrEMBL
    B4DJS8
    Conserved Domains (2) summary
    cd22062
    Location:408 → 438
    WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
    cl21453
    Location:61 → 208
    PKc_like; Protein Kinases, catalytic domain

  7. NM_001349488.2 → NP_001336417.1  PX domain-containing protein kinase-like protein isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variant 4, encodes isoform d.
    Source sequence(s)
    AC098479, AC135507
    Consensus CDS
    CCDS74952.1
    UniProtKB/TrEMBL
    B4DID9
    Conserved Domains (3) summary
    cd06871
    Location:13 → 132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:186 → 492
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:198 → 345
    PKc; Catalytic domain of Protein Kinases

  8. NM_001349489.2 → NP_001336418.1  PX domain-containing protein kinase-like protein isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variant 5, encodes isoform e.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DJS8
    Conserved Domains (3) summary
    cd22062
    Location:462 → 492
    WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
    cl02563
    Location:1 → 49
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl21453
    Location:115 → 262
    PKc_like; Protein Kinases, catalytic domain

  9. NM_001349490.2 → NP_001336419.1  PX domain-containing protein kinase-like protein isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variant 6, encodes isoform f.
    Source sequence(s)
    AC098479, AC135507
    Consensus CDS
    CCDS74955.1
    UniProtKB/TrEMBL
    B4DID9, E9PD56
    Conserved Domains (3) summary
    COG0515
    Location:153 → 459
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:165 → 312
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:13 → 99
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  10. NM_001349491.2 → NP_001336420.1  PX domain-containing protein kinase-like protein isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variant 7, encodes isoform g.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DJS8
    Conserved Domains (2) summary
    cd22062
    Location:408 → 438
    WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
    cl21453
    Location:61 → 208
    PKc_like; Protein Kinases, catalytic domain

  11. NM_001349492.2 → NP_001336421.1  PX domain-containing protein kinase-like protein isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) encodes the longest isoform (h).
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DID9
    Conserved Domains (3) summary
    cd06871
    Location:13 → 132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:186 → 492
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:198 → 345
    PKc; Catalytic domain of Protein Kinases

  12. NM_001349493.2 → NP_001336422.1  PX domain-containing protein kinase-like protein isoform i

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) encodes isoform i.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (2) summary
    cd06871
    Location:13 → 132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cl21453
    Location:198 → 345
    PKc_like; Protein Kinases, catalytic domain

  13. NM_001349494.2 → NP_001336423.1  PX domain-containing protein kinase-like protein isoform j

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) encodes isoform j.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (3) summary
    cd06871
    Location:13 → 116
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd22062
    Location:529 → 559
    WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
    cl21453
    Location:182 → 329
    PKc_like; Protein Kinases, catalytic domain

  14. NM_001349495.2 → NP_001336424.1  PX domain-containing protein kinase-like protein isoform k

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15) encodes isoform k.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (3) summary
    cd06871
    Location:13 → 116
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd22062
    Location:528 → 558
    WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
    cl21453
    Location:182 → 329
    PKc_like; Protein Kinases, catalytic domain

  15. NM_001349496.2 → NP_001336425.1  PX domain-containing protein kinase-like protein isoform jj

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16) encodes isoform jj.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (3) summary
    COG0515
    Location:169 → 475
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:181 → 328
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:13 → 115
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  16. NM_001349497.2 → NP_001336426.1  PX domain-containing protein kinase-like protein isoform l

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17) encodes isoform l.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (2) summary
    cd00180
    Location:181 → 328
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:13 → 115
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  17. NM_001349498.1 → NP_001336427.1  PX domain-containing protein kinase-like protein isoform m

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18) encodes isoform m.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    W5RWD6
    Conserved Domains (3) summary
    cd06871
    Location:15 → 112
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:166 → 472
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:178 → 325
    PKc; Catalytic domain of Protein Kinases

  18. NM_001349499.2 → NP_001336428.1  PX domain-containing protein kinase-like protein isoform n

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19) encodes isoform n.
    Source sequence(s)
    AC098479, AC135507
    Consensus CDS
    CCDS87097.1
    UniProtKB/TrEMBL
    W5RWE6
    Related
    ENSP00000305045.6, ENST00000302779.9
    Conserved Domains (3) summary
    cd06871
    Location:13 → 132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:186 → 526
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:198 → 345
    PKc; Catalytic domain of Protein Kinases

  19. NM_001349500.2 → NP_001336429.1  PX domain-containing protein kinase-like protein isoform o

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20) encodes isoform o.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DJS8
    Conserved Domains (2) summary
    cd00180
    Location:165 → 312
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:13 → 99
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  20. NM_001349501.2 → NP_001336430.1  PX domain-containing protein kinase-like protein isoform p

    Status: VALIDATED

    Description
    Transcript Variant: This variant (21) encodes isoform p.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (3) summary
    cd06871
    Location:13 → 116
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:170 → 510
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:182 → 329
    PKc; Catalytic domain of Protein Kinases

  21. NM_001349502.2 → NP_001336431.1  PX domain-containing protein kinase-like protein isoform q

    Status: VALIDATED

    Description
    Transcript Variant: This variant (22) encodes isoform q.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (3) summary
    COG0515
    Location:169 → 509
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:181 → 328
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:13 → 115
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  22. NM_001349503.2 → NP_001336432.1  PX domain-containing protein kinase-like protein isoform r

    Status: VALIDATED

    Description
    Transcript Variant: This variant (23), as well as variant 26, encodes isoform r.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DID9
    Conserved Domains (3) summary
    cd06871
    Location:13 → 132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:186 → 492
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:198 → 345
    PKc; Catalytic domain of Protein Kinases

  23. NM_001349504.2 → NP_001336433.1  PX domain-containing protein kinase-like protein isoform kk

    Status: VALIDATED

    Description
    Transcript Variant: This variant (24), as well as variant 25, encodes isoform kk.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DID9
    Conserved Domains (2) summary
    cd06871
    Location:13 → 132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:198 → 345
    PKc; Catalytic domain of Protein Kinases

  24. NM_001349506.2 → NP_001336435.1  PX domain-containing protein kinase-like protein isoform kk

    Status: VALIDATED

    Description
    Transcript Variant: This variant (25), as well as variant 24, encodes isoform kk.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DID9
    Conserved Domains (2) summary
    cd06871
    Location:13 → 132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:198 → 345
    PKc; Catalytic domain of Protein Kinases

  25. NM_001349507.2 → NP_001336436.1  PX domain-containing protein kinase-like protein isoform r

    Status: VALIDATED

    Description
    Transcript Variant: This variant (26), as well as variant 23, encodes isoform r.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DID9
    Conserved Domains (3) summary
    cd06871
    Location:13 → 132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:186 → 492
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:198 → 345
    PKc; Catalytic domain of Protein Kinases

  26. NM_001349508.2 → NP_001336437.1  PX domain-containing protein kinase-like protein isoform s

    Status: VALIDATED

    Description
    Transcript Variant: This variant (27), as well as variant 28, encodes isoform s.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DID9
    Conserved Domains (2) summary
    cd06871
    Location:13 → 132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:198 → 345
    PKc; Catalytic domain of Protein Kinases

  27. NM_001349509.2 → NP_001336438.1  PX domain-containing protein kinase-like protein isoform s

    Status: VALIDATED

    Description
    Transcript Variant: This variant (28), as well as variant 27, encodes isoform s.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DID9
    Conserved Domains (2) summary
    cd06871
    Location:13 → 132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:198 → 345
    PKc; Catalytic domain of Protein Kinases

  28. NM_001349510.2 → NP_001336439.1  PX domain-containing protein kinase-like protein isoform t

    Status: VALIDATED

    Description
    Transcript Variant: This variant (29) encodes isoform t.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DID9
    Conserved Domains (3) summary
    cd06871
    Location:13 → 116
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:170 → 476
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:182 → 329
    PKc; Catalytic domain of Protein Kinases

  29. NM_001349511.2 → NP_001336440.1  PX domain-containing protein kinase-like protein isoform u

    Status: VALIDATED

    Description
    Transcript Variant: This variant (30) encodes isoform u.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DID9
    Conserved Domains (2) summary
    cd06871
    Location:13 → 116
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:182 → 329
    PKc; Catalytic domain of Protein Kinases

  30. NM_001349512.2 → NP_001336441.1  PX domain-containing protein kinase-like protein isoform ll

    Status: VALIDATED

    Description
    Transcript Variant: This variant (31) encodes isoform ll.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DID9
    Conserved Domains (3) summary
    cd06871
    Location:13 → 116
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:170 → 476
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:182 → 329
    PKc; Catalytic domain of Protein Kinases

  31. NM_001349513.2 → NP_001336442.1  PX domain-containing protein kinase-like protein isoform mm

    Status: VALIDATED

    Description
    Transcript Variant: This variant (32) encodes isoform mm.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DID9
    Conserved Domains (3) summary
    COG0515
    Location:103 → 409
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:115 → 262
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:1 → 49
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  32. NM_001349514.2 → NP_001336443.1  PX domain-containing protein kinase-like protein isoform nn

    Status: VALIDATED

    Description
    Transcript Variant: This variant (33) encodes isoform nn.
    Source sequence(s)
    AC098479, AC135507
    Consensus CDS
    CCDS87098.1
    UniProtKB/TrEMBL
    B4DID9, H7BYG4
    Related
    ENSP00000373221.4, ENST00000383715.8
    Conserved Domains (3) summary
    COG0515
    Location:169 → 475
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:181 → 328
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:13 → 115
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  33. NM_001349515.2 → NP_001336444.1  PX domain-containing protein kinase-like protein isoform v

    Status: VALIDATED

    Description
    Transcript Variant: This variant (34) encodes isoform v.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DID9
    Conserved Domains (2) summary
    cd00180
    Location:181 → 328
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:13 → 115
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  34. NM_001349516.2 → NP_001336445.1  PX domain-containing protein kinase-like protein isoform oo

    Status: VALIDATED

    Description
    Transcript Variant: This variant (35) encodes isoform oo.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DID9
    Conserved Domains (2) summary
    cd06871
    Location:13 → 116
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd00180
    Location:182 → 329
    PKc; Catalytic domain of Protein Kinases

  35. NM_001349517.2 → NP_001336446.1  PX domain-containing protein kinase-like protein isoform pp

    Status: VALIDATED

    Description
    Transcript Variant: This variant (36) encodes isoform pp.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DID9
    Conserved Domains (3) summary
    COG0515
    Location:169 → 475
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:181 → 328
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:13 → 115
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  36. NM_001349518.2 → NP_001336447.1  PX domain-containing protein kinase-like protein isoform w

    Status: VALIDATED

    Description
    Transcript Variant: This variant (37) encodes isoform w.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DID9
    Conserved Domains (2) summary
    cd00180
    Location:181 → 328
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:13 → 115
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  37. NM_001349519.2 → NP_001336448.1  PX domain-containing protein kinase-like protein isoform x

    Status: VALIDATED

    Description
    Transcript Variant: This variant (38), as well as variant 39, encodes isoform x.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DID9
    Conserved Domains (3) summary
    cd06871
    Location:13 → 132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:186 → 493
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:198 → 345
    PKc; Catalytic domain of Protein Kinases

  38. NM_001349520.2 → NP_001336449.1  PX domain-containing protein kinase-like protein isoform x

    Status: VALIDATED

    Description
    Transcript Variant: This variant (39), as well as variant 38, encodes isoform x.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DID9
    Conserved Domains (3) summary
    cd06871
    Location:13 → 132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:186 → 493
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:198 → 345
    PKc; Catalytic domain of Protein Kinases

  39. NM_001349521.2 → NP_001336450.1  PX domain-containing protein kinase-like protein isoform qq

    Status: VALIDATED

    Description
    Transcript Variant: This variant (40) encodes isoform qq.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DJS8
    Conserved Domains (2) summary
    cd00180
    Location:115 → 262
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:1 → 49
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  40. NM_001349522.2 → NP_001336451.1  PX domain-containing protein kinase-like protein isoform y

    Status: VALIDATED

    Description
    Transcript Variant: This variant (41) encodes isoform y.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DID9
    Conserved Domains (3) summary
    COG0515
    Location:153 → 459
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:165 → 312
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:13 → 99
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  41. NM_001349524.2 → NP_001336453.1  PX domain-containing protein kinase-like protein isoform z

    Status: VALIDATED

    Description
    Transcript Variant: This variant (42) encodes isoform z.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DID9
    Conserved Domains (2) summary
    cd00180
    Location:165 → 312
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:13 → 99
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  42. NM_001349525.2 → NP_001336454.1  PX domain-containing protein kinase-like protein isoform aa

    Status: VALIDATED

    Description
    Transcript Variant: This variant (43) encodes isoform aa.
    Source sequence(s)
    AC098479, AC135507
    Conserved Domains (2) summary
    COG0515
    Location:49 → 355
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:61 → 208
    PKc; Catalytic domain of Protein Kinases

  43. NM_001349526.2 → NP_001336455.1  PX domain-containing protein kinase-like protein isoform bb

    Status: VALIDATED

    Description
    Transcript Variant: This variant (44) encodes isoform bb.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DJS8
    Conserved Domains (2) summary
    cd22062
    Location:407 → 437
    WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
    cl21453
    Location:61 → 208
    PKc_like; Protein Kinases, catalytic domain

  44. NM_001349527.2 → NP_001336456.1  PX domain-containing protein kinase-like protein isoform cc

    Status: VALIDATED

    Description
    Transcript Variant: This variant (45) encodes isoform cc.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DID9
    Conserved Domains (3) summary
    cd06871
    Location:13 → 132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    COG0515
    Location:186 → 492
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:198 → 345
    PKc; Catalytic domain of Protein Kinases

  45. NM_001349528.2 → NP_001336457.1  PX domain-containing protein kinase-like protein isoform dd

    Status: VALIDATED

    Description
    Transcript Variant: This variant (46), as well as variant 47, encodes isoform dd.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DID9
    Conserved Domains (3) summary
    COG0515
    Location:103 → 409
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:115 → 262
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:1 → 49
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  46. NM_001349529.2 → NP_001336458.1  PX domain-containing protein kinase-like protein isoform dd

    Status: VALIDATED

    Description
    Transcript Variant: This variant (47), as well as variant 46, encodes isoform dd.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DID9
    Conserved Domains (3) summary
    COG0515
    Location:103 → 409
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:115 → 262
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:1 → 49
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  47. NM_001349530.2 → NP_001336459.1  PX domain-containing protein kinase-like protein isoform ee

    Status: VALIDATED

    Description
    Transcript Variant: This variant (48) encodes isoform ee.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DID9
    Conserved Domains (2) summary
    cd00180
    Location:115 → 262
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:1 → 49
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  48. NM_001349531.2 → NP_001336460.1  PX domain-containing protein kinase-like protein isoform rr

    Status: VALIDATED

    Description
    Transcript Variant: This variant (49) encodes isoform rr.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DID9
    Conserved Domains (3) summary
    COG0515
    Location:103 → 409
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:115 → 262
    PKc; Catalytic domain of Protein Kinases
    cl02563
    Location:1 → 49
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  49. NM_001349532.2 → NP_001336461.1  PX domain-containing protein kinase-like protein isoform ff

    Status: VALIDATED

    Description
    Transcript Variant: This variant (50) encodes isoform ff.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DJS8
    Conserved Domains (2) summary
    COG0515
    Location:49 → 389
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:61 → 208
    PKc; Catalytic domain of Protein Kinases

  50. NM_001349533.2 → NP_001336462.1  PX domain-containing protein kinase-like protein isoform gg

    Status: VALIDATED

    Description
    Transcript Variant: This variant (51), as well as variant 52, encodes isoform gg.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DJD8
    Conserved Domains (2) summary
    COG0515
    Location:49 → 355
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:61 → 208
    PKc; Catalytic domain of Protein Kinases

  51. NM_001349534.2 → NP_001336463.1  PX domain-containing protein kinase-like protein isoform gg

    Status: VALIDATED

    Description
    Transcript Variant: This variant (52), as well as variant 51, encodes isoform gg.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DJD8
    Conserved Domains (2) summary
    COG0515
    Location:49 → 355
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:61 → 208
    PKc; Catalytic domain of Protein Kinases

  52. NM_001349535.2 → NP_001336464.1  PX domain-containing protein kinase-like protein isoform hh

    Status: VALIDATED

    Description
    Transcript Variant: This variant (53), as well as variant 54, encodes isoform hh.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DJD8
    Conserved Domains (2) summary
    COG0515
    Location:49 → 355
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:61 → 208
    PKc; Catalytic domain of Protein Kinases

  53. NM_001349536.2 → NP_001336465.1  PX domain-containing protein kinase-like protein isoform hh

    Status: VALIDATED

    Description
    Transcript Variant: This variant (54), as well as variant 53, encodes isoform hh.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DJD8
    Conserved Domains (2) summary
    COG0515
    Location:49 → 355
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00180
    Location:61 → 208
    PKc; Catalytic domain of Protein Kinases

  54. NM_001349537.2 → NP_001336466.1  PX domain-containing protein kinase-like protein isoform ss

    Status: VALIDATED

    Description
    Transcript Variant: This variant (55), as well as variant 56, encodes isoform ss.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DJD8
    Conserved Domains (1) summary
    cd00180
    Location:61 → 208
    PKc; Catalytic domain of Protein Kinases

  55. NM_001349538.2 → NP_001336467.1  PX domain-containing protein kinase-like protein isoform ss

    Status: VALIDATED

    Description
    Transcript Variant: This variant (56), as well as variant 55, encodes isoform ss.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DJD8
    Conserved Domains (1) summary
    cd00180
    Location:61 → 208
    PKc; Catalytic domain of Protein Kinases

  56. NM_001349539.2 → NP_001336468.1  PX domain-containing protein kinase-like protein isoform ii

    Status: VALIDATED

    Description
    Transcript Variant: This variant (57), as well as variant 58, encodes isoform ii.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DJD8
    Conserved Domains (1) summary
    cd00180
    Location:61 → 208
    PKc; Catalytic domain of Protein Kinases

  57. NM_001349540.2 → NP_001336469.1  PX domain-containing protein kinase-like protein isoform ii

    Status: VALIDATED

    Description
    Transcript Variant: This variant (58), as well as variant 57, encodes isoform ii.
    Source sequence(s)
    AC098479, AC135507
    UniProtKB/TrEMBL
    B4DJD8
    Conserved Domains (1) summary
    cd00180
    Location:61 → 208
    PKc; Catalytic domain of Protein Kinases

  58. NM_017771.5 → NP_060241.2  PX domain-containing protein kinase-like protein isoform a

    See identical proteins and their annotated locations for NP_060241.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a (also known as isoform 1).
    Source sequence(s)
    AK296034, AL137938, AY274811, DQ124707, DQ124708, HY164612
    Consensus CDS
    CCDS2889.1
    UniProtKB/Swiss-Prot
    Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q7Z7A4, Q96CA3, Q96R07, Q9NXB8
    Related
    ENSP00000348472.2, ENST00000356151.7
    Conserved Domains (3) summary
    cd06871
    Location:13 → 132
    PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
    cd22062
    Location:545 → 575
    WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
    cl21453
    Location:198 → 345
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. NR_146193.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC098479, AC135507

  2. NR_146194.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC098479, AC135507

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    58332892..58426127
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    58373299..58466504
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z7A4.1 GenPept UniProtKB/Swiss-Prot:Q7Z7A4

Gene LinkOut

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Chemical Information
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