azin1a antizyme inhibitor 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: azin1aprovided by ZNC
Official Full Name: antizyme inhibitor 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050417-20
See related: Ensembl:ENSDARG00000052789 AllianceGenome:ZFIN:ZDB-GENE-050417-20
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fc93f10; zgc:110131
Summary: The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes one of two copies of antizyme inhibitor 1 in zebrafish. [provided by RefSeq, May 2015]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (52708030..52736552, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (52822282..52850806, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables ornithine decarboxylase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables ornithine decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within polyamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of polyamine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in putrescine biosynthetic process from ornithine	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: antizyme inhibitor 1a

Names: ornithine decarboxylase antizyme inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017568.3 → NP_001017568.2 antizyme inhibitor 1a

See identical proteins and their annotated locations for NP_001017568.2

Status: REVIEWED

Source sequence(s)

CR524823

UniProtKB/TrEMBL

A0A8M1N598, F1QZN2

Related

ENSDARP00000056100.6, ENSDART00000056101.6

Conserved Domains (2) summary

TIGR03099
Location:42 → 401

dCO2ase_PEP1; pyridoxal-dependent decarboxylase, exosortase A system-associated

cl00261
Location:28 → 424

PLPDE_III; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007127.7 Reference GRCz11 Primary Assembly

Range

52708030..52736552 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005158442.4 → XP_005158499.1 antizyme inhibitor 1a isoform X1

See identical proteins and their annotated locations for XP_005158499.1

UniProtKB/TrEMBL

A0A8M1N598, F1QZN2

Conserved Domains (2) summary

TIGR03099
Location:42 → 401

dCO2ase_PEP1; pyridoxal-dependent decarboxylase, exosortase A system-associated

cl00261
Location:28 → 424

PLPDE_III; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes