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dcxr dicarbonyl/L-xylulose reductase [ Danio rerio (zebrafish) ]

Gene ID: 550282, updated on 2-Nov-2024

Summary

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Official Symbol
dcxrprovided by ZNC
Official Full Name
dicarbonyl/L-xylulose reductaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-7002
See related
Ensembl:ENSDARG00000079271 AllianceGenome:ZFIN:ZDB-GENE-030131-7002
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fa12f09; zgc:111977
Summary
Predicted to enable L-xylulose reductase (NADPH) activity and carbonyl reductase (NADPH) activity. Predicted to be involved in glucose metabolic process and xylulose metabolic process. Human ortholog(s) of this gene implicated in pentosuria. Orthologous to human DCXR (dicarbonyl and L-xylulose reductase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See dcxr in Genome Data Viewer
Location:
chromosome: 12
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (3043303..3053545, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (3008575..3019006, complement)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 45 Neighboring gene Rac family small GTPase 3b Neighboring gene RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene sarcoglycan, alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolutionary emergence of the rac3b/rfng/sgca regulatory cluster refined mechanisms for hindbrain boundaries formation. Letelier J, et al. Proc Natl Acad Sci U S A, 2018 Apr 17. PMID 29610331, Free PMC Article
  2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables L-xylulose reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-xylulose reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
enables carbonyl reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in xylulose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
L-xylulose reductase
NP_001017619.1
XP_005156041.1
XP_068080694.1
XP_068080695.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017619.1 → NP_001017619.1  L-xylulose reductase

    See identical proteins and their annotated locations for NP_001017619.1

    Status: PROVISIONAL

    Source sequence(s)
    BC093141
    UniProtKB/TrEMBL
    A0A8M1N5D6, Q567K5
    Related
    ENSDARP00000019859.7, ENSDART00000023796.9
    Conserved Domains (2) summary
    PRK07060
    Location:1 → 243
    PRK07060; short chain dehydrogenase; Provisional
    cd05351
    Location:1 → 244
    XR_like_SDR_c; xylulose reductase-like, classical (c) SDRs

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    3043303..3053545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068224594.1 → XP_068080695.1  L-xylulose reductase isoform X1

  2. XM_068224593.1 → XP_068080694.1  L-xylulose reductase isoform X1

  3. XM_005155984.5 → XP_005156041.1  L-xylulose reductase isoform X1

    See identical proteins and their annotated locations for XP_005156041.1

    UniProtKB/TrEMBL
    A0A8M1N5D6, Q567K5
    Related
    ENSDARP00000119912.1, ENSDART00000137148.3
    Conserved Domains (2) summary
    PRK07060
    Location:1 → 243
    PRK07060; short chain dehydrogenase; Provisional
    cd05351
    Location:1 → 244
    XR_like_SDR_c; xylulose reductase-like, classical (c) SDRs
Nucleotide Protein
Heading Accession and Version

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