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CEP192 centrosomal protein 192 [ Homo sapiens (human) ]

Gene ID: 55125, updated on 14-Nov-2024

Summary

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Official Symbol
CEP192provided by HGNC
Official Full Name
centrosomal protein 192provided by HGNC
Primary source
HGNC:HGNC:25515
See related
Ensembl:ENSG00000101639 MIM:616426; AllianceGenome:HGNC:25515
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPP1R62
Summary
Enables phosphatase binding activity. Involved in centrosome-templated microtubule nucleation; mitotic spindle assembly; and protein localization to centrosome. Located in centriole and centrosome. Part of procentriole and procentriole replication complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis (RPKM 8.2), gall bladder (RPKM 6.1) and 25 other tissues See more
Orthologs
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Genomic context

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See CEP192 in Genome Data Viewer
Location:
18p11.21
Exon count:
47
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (12991362..13125036)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (13154097..13287771)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (12991361..13125035)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4A2 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 933 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9323 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9324 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:12948589-12949190 Neighboring gene SEH1 like nucleoporin Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:12989680-12990292 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13112 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9326 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9327 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9328 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:13061945-13062156 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:13068543-13069742 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13135678-13136257 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13136258-13136836 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13113 Neighboring gene Sharpr-MPRA regulatory region 6122 Neighboring gene WD repeat domain 89 pseudogene Neighboring gene MRT4 homolog, ribosome maturation factor pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Recruitment of PP1 to the centrosomal scaffold protein CEP192. Nasa I, et al. Biochem Biophys Res Commun, 2017 Mar 18. PMID 28188792, Free PMC Article
  2. Centriole and PCM cooperatively recruit CEP192 to spindle poles to promote bipolar spindle assembly. Chinen T, et al. J Cell Biol, 2021 Feb 1. PMID 33443571, Free PMC Article
  3. Cep192 controls the balance of centrosome and non-centrosomal microtubules during interphase. O'Rourke BP, et al. PLoS One, 2014. PMID 24971877, Free PMC Article
  4. CEP192 is a novel prognostic marker and correlates with the immune microenvironment in hepatocellular carcinoma. Liu Y, et al. Front Immunol, 2022. PMID 36238304, Free PMC Article
  5. Mosaic variegated aneuploidy syndrome with tetraploid, and predisposition to male infertility triggered by mutant CEP192. Guo J, et al. HGG Adv, 2024 Jan 11. PMID 37981762, Free PMC Article

See all (91) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mosaic variegated aneuploidy syndrome with tetraploid, and predisposition to male infertility triggered by mutant CEP192.
    Title: Mosaic variegated aneuploidy syndrome with tetraploid, and predisposition to male infertility triggered by mutant CEP192.
  2. CEP192 is a novel prognostic marker and correlates with the immune microenvironment in hepatocellular carcinoma.
    Title: CEP192 is a novel prognostic marker and correlates with the immune microenvironment in hepatocellular carcinoma.
  3. Centriole and PCM cooperatively recruit CEP192 to spindle poles to promote bipolar spindle assembly.
    Title: Centriole and PCM cooperatively recruit CEP192 to spindle poles to promote bipolar spindle assembly.
  4. Identification of genes in hepatocellular carcinoma induced by non-alcoholic fatty liver disease.
    Title: Identification of genes in hepatocellular carcinoma induced by non-alcoholic fatty liver disease.
  5. induced FBXL13 expression downregulates centrosomal gamma-tubulin and disrupts centrosomal microtubule arrays. In addition, depletion of FBXL13 induces high levels of CEP192 and gamma-tubulin at the centrosomes with the consequence of defects in cell motility.
    Title: FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration.
  6. Study shows that the interaction between Cep295 and Cep192 seems to be crucial for the integrity of centriole structure and also for daughter-to-mother centriole conversion.
    Title: Cep295 is a conserved scaffold protein required for generation of a bona fide mother centriole.
  7. Here we demonstrate that CEP192 also recruits the type one protein phosphatase (PP1) via a highly conserved KHVTF docking motif.
    Title: Recruitment of PP1 to the centrosomal scaffold protein CEP192.
  8. Interphase cells depleted of Cep192 display significantly higher levels of centrosome-associated Pericentrin while overexpression of Cep192 reduces the levels of centrosomal Pericentrin.
    Title: Cep192 controls the balance of centrosome and non-centrosomal microtubules during interphase.
  9. Plk1 promotes centrosome-based bipolar spindle formation by forming two functionally nonredundant complexes with Cep192.
    Title: Bimodal Interaction of Mammalian Polo-Like Kinase 1 and a Centrosomal Scaffold, Cep192, in the Regulation of Bipolar Spindle Formation.
  10. Study identifies a Cep192-organized signaling cascade that underlies both centrosome maturation and bipolar spindle assembly.
    Title: The Cep192-organized aurora A-Plk1 cascade is essential for centrosome cycle and bipolar spindle assembly.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphatase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in centriole replication NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in centrosome cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in centrosome-templated microtubule nucleation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to centrosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to bacterium IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in pericentriolar material IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in procentriole IDA
Inferred from Direct Assay
more info
 PubMed 
part_of procentriole replication complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
centrosomal protein of 192 kDa
Names
192 kDa centrosomal protein
centrosomal protein 192kDa
cep192/SPD-2
protein phosphatase 1, regulatory subunit 62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032142.4 → NP_115518.3  centrosomal protein of 192 kDa

    Status: VALIDATED

    Source sequence(s)
    AB046789, AK096548, AL833494, BC144481, BX648232, DB079620
    Consensus CDS
    CCDS32792.2
    UniProtKB/Swiss-Prot
    A0A060A9S4, B7ZMF0, E9PF99, Q8TEP8, Q8WYT8, Q9H0F4, Q9NW27
    UniProtKB/TrEMBL
    K7ENP4
    Related
    ENSP00000427550.1, ENST00000506447.5
    Conserved Domains (1) summary
    pfam08626
    Location:1677 → 1767
    TRAPPC9-Trs120; Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    12991362..13125036
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722326.4 → XP_006722389.1  centrosomal protein of 192 kDa isoform X2

    UniProtKB/TrEMBL
    K7ENP4
    Conserved Domains (1) summary
    cl13764
    Location:1660 → 1724
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

  2. XM_005258107.4 → XP_005258164.1  centrosomal protein of 192 kDa isoform X1

    UniProtKB/TrEMBL
    K7ENP4
    Conserved Domains (1) summary
    cl13764
    Location:1660 → 1724
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

  3. XM_047437562.1 → XP_047293518.1  centrosomal protein of 192 kDa isoform X3

  4. XM_047437564.1 → XP_047293520.1  centrosomal protein of 192 kDa isoform X8

  5. XM_011525673.3 → XP_011523975.1  centrosomal protein of 192 kDa isoform X4

    UniProtKB/TrEMBL
    K7ENP4
    Conserved Domains (1) summary
    cl13764
    Location:1660 → 1727
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

  6. XM_047437565.1 → XP_047293521.1  centrosomal protein of 192 kDa isoform X9

  7. XM_047437563.1 → XP_047293519.1  centrosomal protein of 192 kDa isoform X5

  8. XM_047437566.1 → XP_047293522.1  centrosomal protein of 192 kDa isoform X10

  9. XM_005258109.4 → XP_005258166.1  centrosomal protein of 192 kDa isoform X6

    UniProtKB/TrEMBL
    K7ENP4
    Conserved Domains (1) summary
    cl13764
    Location:1590 → 1654
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

  10. XM_047437567.1 → XP_047293523.1  centrosomal protein of 192 kDa isoform X11

  11. XM_006722327.4 → XP_006722390.1  centrosomal protein of 192 kDa isoform X7

    UniProtKB/TrEMBL
    K7ENP4
    Related
    ENSP00000317156.9, ENST00000325971.12
    Conserved Domains (1) summary
    cl13764
    Location:1590 → 1654
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

  12. XM_047437568.1 → XP_047293524.1  centrosomal protein of 192 kDa isoform X13

  13. XM_047437569.1 → XP_047293525.1  centrosomal protein of 192 kDa isoform X14

  14. XM_006722330.4 → XP_006722393.1  centrosomal protein of 192 kDa isoform X20

    UniProtKB/TrEMBL
    A0A0A0MR42
    Conserved Domains (1) summary
    cl13764
    Location:1321 → 1385
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

  15. XM_017025804.2 → XP_016881293.1  centrosomal protein of 192 kDa isoform X21

    UniProtKB/TrEMBL
    A0A0A0MR42

  16. XM_047437575.1 → XP_047293531.1  centrosomal protein of 192 kDa isoform X22

  17. XM_047437571.1 → XP_047293527.1  centrosomal protein of 192 kDa isoform X16

  18. XM_047437573.1 → XP_047293529.1  centrosomal protein of 192 kDa isoform X18

  19. XM_047437570.1 → XP_047293526.1  centrosomal protein of 192 kDa isoform X15

  20. XM_047437572.1 → XP_047293528.1  centrosomal protein of 192 kDa isoform X17

  21. XM_047437576.1 → XP_047293532.1  centrosomal protein of 192 kDa isoform X23

  22. XM_047437579.1 → XP_047293535.1  centrosomal protein of 192 kDa isoform X26

  23. XM_011525675.4 → XP_011523977.2  centrosomal protein of 192 kDa isoform X12

    UniProtKB/TrEMBL
    K7ENP4
    Conserved Domains (1) summary
    pfam08626
    Location:1587 → 1677
    TRAPPC9-Trs120; Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit

  24. XM_047437574.1 → XP_047293530.1  centrosomal protein of 192 kDa isoform X19

    Related
    ENSP00000423147.1, ENST00000510237.5

  25. XM_047437577.1 → XP_047293533.1  centrosomal protein of 192 kDa isoform X24

    Related
    ENSP00000467038.1, ENST00000511820.6

  26. XM_047437578.1 → XP_047293534.1  centrosomal protein of 192 kDa isoform X25

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    13154097..13287771
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054318718.1 → XP_054174693.1  centrosomal protein of 192 kDa isoform X2

  2. XM_054318717.1 → XP_054174692.1  centrosomal protein of 192 kDa isoform X1

  3. XM_054318719.1 → XP_054174694.1  centrosomal protein of 192 kDa isoform X3

  4. XM_054318724.1 → XP_054174699.1  centrosomal protein of 192 kDa isoform X8

  5. XM_054318720.1 → XP_054174695.1  centrosomal protein of 192 kDa isoform X4

  6. XM_054318725.1 → XP_054174700.1  centrosomal protein of 192 kDa isoform X9

  7. XM_054318721.1 → XP_054174696.1  centrosomal protein of 192 kDa isoform X5

  8. XM_054318726.1 → XP_054174701.1  centrosomal protein of 192 kDa isoform X10

  9. XM_054318722.1 → XP_054174697.1  centrosomal protein of 192 kDa isoform X6

  10. XM_054318727.1 → XP_054174702.1  centrosomal protein of 192 kDa isoform X11

  11. XM_054318723.1 → XP_054174698.1  centrosomal protein of 192 kDa isoform X7

  12. XM_054318729.1 → XP_054174704.1  centrosomal protein of 192 kDa isoform X13

  13. XM_054318730.1 → XP_054174705.1  centrosomal protein of 192 kDa isoform X14

  14. XM_054318736.1 → XP_054174711.1  centrosomal protein of 192 kDa isoform X20

  15. XM_054318737.1 → XP_054174712.1  centrosomal protein of 192 kDa isoform X21

  16. XM_054318738.1 → XP_054174713.1  centrosomal protein of 192 kDa isoform X22

  17. XM_054318732.1 → XP_054174707.1  centrosomal protein of 192 kDa isoform X16

  18. XM_054318734.1 → XP_054174709.1  centrosomal protein of 192 kDa isoform X18

  19. XM_054318731.1 → XP_054174706.1  centrosomal protein of 192 kDa isoform X15

  20. XM_054318733.1 → XP_054174708.1  centrosomal protein of 192 kDa isoform X17

  21. XM_054318739.1 → XP_054174714.1  centrosomal protein of 192 kDa isoform X23

  22. XM_054318742.1 → XP_054174717.1  centrosomal protein of 192 kDa isoform X26

  23. XM_054318728.1 → XP_054174703.1  centrosomal protein of 192 kDa isoform X12

  24. XM_054318735.1 → XP_054174710.1  centrosomal protein of 192 kDa isoform X19

  25. XM_054318740.1 → XP_054174715.1  centrosomal protein of 192 kDa isoform X24

  26. XM_054318741.1 → XP_054174716.1  centrosomal protein of 192 kDa isoform X25

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_018069.2: Suppressed sequence

    Description
    NM_018069.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TEP8.3 GenPept UniProtKB/Swiss-Prot:Q8TEP8

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