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ora1 olfactory receptor class A related 1 [ Danio rerio (zebrafish) ]

Gene ID: 553133, updated on 2-Nov-2024

Summary

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Official Symbol
ora1provided by ZNC
Official Full Name
olfactory receptor class A related 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-050510-2
See related
Ensembl:ENSDARG00000098601 AllianceGenome:ZFIN:ZDB-GENE-050510-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
vir2; vn1r1l; zgc:194316
Summary
Enables L-tyrosine binding activity; monocarboxylic acid binding activity; and pheromone binding activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway; response to pheromone; and sensory perception of smell. Located in plasma membrane. Is expressed in female organism; male organism; olfactory epithelium; and olfactory rosette. Orthologous to several human genes including VN1R1 (vomeronasal 1 receptor 1); VN1R2 (vomeronasal 1 receptor 2); and VN1R3 (vomeronasal 1 receptor 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ora1 in Genome Data Viewer
Location:
chromosome: 22
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (208644..209741, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (222601..223698)

Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 34 Neighboring gene rootletin-like Neighboring gene F-box protein 42 Neighboring gene olfactory receptor class A-like protein 1 Neighboring gene olfactory receptor class A related 2 Neighboring gene zgc:66156

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ORA1, a zebrafish olfactory receptor ancestral to all mammalian V1R genes, recognizes 4-hydroxyphenylacetic acid, a putative reproductive pheromone. Behrens M, et al. J Biol Chem, 2014 Jul 11. PMID 24831010, Free PMC Article
  2. Divergent evolution among teleost V1r receptor genes. Pfister P, et al. PLoS One, 2007 Apr 18. PMID 17440615, Free PMC Article
  3. Olfactory expression of a single and highly variable V1r pheromone receptor-like gene in fish species. Pfister P, et al. Proc Natl Acad Sci U S A, 2005 Apr 12. PMID 15809442, Free PMC Article
  4. Spatial organization of olfactory receptor gene choice in the complete V1R-related ORA family of zebrafish. Kowatschew D, et al. Sci Rep, 2022 Aug 31. PMID 36045218, Free PMC Article
  5. A novel olfactory receptor gene family in teleost fish. Saraiva LR, et al. Genome Res, 2007 Oct. PMID 17717047, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. 4-hydroxyphenylacetic acid might function as a pheromone for reproductive behavior in zebrafish. ORA1 is ancestral to mammalian V1Rs
    Title: ORA1, a zebrafish olfactory receptor ancestral to all mammalian V1R genes, recognizes 4-hydroxyphenylacetic acid, a putative reproductive pheromone.
Submit: New GeneRIF Correction

General gene information

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Homology

Clone Names

  • MGC194316

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables L-tyrosine binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables monocarboxylic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables pheromone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables pheromone binding IEA
Inferred from Electronic Annotation
more info
  
enables pheromone receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables pheromone receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to pheromone IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sensory perception of smell IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
olfactory receptor class A-like protein 1
Names
V1R2
V1r pheromone receptor-like
V1r-like homolog
vn1r2l
vomeronasal 1 receptor 1 like
vomeronasal type-1 receptor-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130668.1 → NP_001124140.1  olfactory receptor class A-like protein 1

    See identical proteins and their annotated locations for NP_001124140.1

    Status: PROVISIONAL

    Source sequence(s)
    BC163621
    UniProtKB/Swiss-Prot
    A0A0R4IM31, A8E0W7, B3DJV6, Q58QC6, Q597G5
    Related
    ENSDARP00000135478.1, ENSDART00000171954.2
    Conserved Domains (1) summary
    pfam03402
    Location:77 → 291
    V1R; Vomeronasal organ pheromone receptor family, V1R

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007133.7 Reference GRCz11 Primary Assembly

    Range
    208644..209741 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0R4IM31.1 GenPept UniProtKB/Swiss-Prot:A0A0R4IM31

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials