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hs6st1a heparan sulfate 6-O-sulfotransferase 1a [ Danio rerio (zebrafish) ]

Gene ID: 553162, updated on 2-Nov-2024

Summary

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Official Symbol
hs6st1aprovided by ZNC
Official Full Name
heparan sulfate 6-O-sulfotransferase 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050524-1
See related
Ensembl:ENSDARG00000054754 AllianceGenome:ZFIN:ZDB-GENE-050524-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
hs6st1; HS6ST-1; 6-ost-1a; zgc:110038
Summary
Enables heparan sulfate 6-O-sulfotransferase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process, enzymatic modification. Predicted to be located in membrane. Is expressed in several structures, including immature eye; nervous system; neural keel; neural tube; and polster. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 15 with or without anosmia. Orthologous to human HS6ST1 (heparan sulfate 6-O-sulfotransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See hs6st1a in Genome Data Viewer
Location:
chromosome: 2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (40897929..41124040, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (41047443..41269779, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487481 Neighboring gene UDP-glucose glycoprotein glucosyltransferase 1 Neighboring gene uncharacterized LOC137488025 Neighboring gene uncharacterized LOC110438100 Neighboring gene otolith matrix protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Combinatorial expression patterns of heparan sulfate sulfotransferases in zebrafish: II. The 6-O-sulfotransferase family. Cadwallader AB, et al. Dev Dyn, 2006 Dec. PMID 17075883
  2. A unique role for 6-O sulfation modification in zebrafish vascular development. Chen E, et al. Dev Biol, 2005 Aug 15. PMID 16009360
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC110038

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables heparan sulfate 6-O-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heparan sulfate 6-O-sulfotransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
heparan-sulfate 6-O-sulfotransferase 1-A
Names
heparan sulfate 6-O-sulfotransferase 1
NP_001417892.1
XP_068080202.1
XP_068080204.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001430963.1 → NP_001417892.1  heparan-sulfate 6-O-sulfotransferase 1-A

    Status: VALIDATED

    Source sequence(s)
    BX510333, CU929314
    UniProtKB/Swiss-Prot
    A0MGZ4, Q503W9, Q56UJ5
    Related
    ENSDARP00000145279.1, ENSDART00000189011.1

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    40897929..41124040 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068224103.1 → XP_068080204.1  heparan-sulfate 6-O-sulfotransferase 1-A isoform X1

  2. XM_068224101.1 → XP_068080202.1  heparan-sulfate 6-O-sulfotransferase 1-A isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q56UJ5.2 GenPept UniProtKB/Swiss-Prot:Q56UJ5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.