lats1 large tumor suppressor kinase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lats1provided by ZNC
Official Full Name: large tumor suppressor kinase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-050523-2
See related: Ensembl:ENSDARG00000003751 AllianceGenome:ZFIN:ZDB-GENE-050523-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Lats; wu:fc19a11; zgc:123219; si:dkey-181i3.5
Summary: Predicted to enable protein serine/threonine kinase activity. Acts upstream of with a negative effect on BMP signaling pathway. Acts upstream of or within convergent extension involved in gastrulation. Is expressed in several structures, including head; heart; liver; pectoral fin; and pleuroperitoneal region. Used to study autosomal dominant polycystic kidney disease. Orthologous to human LATS1 (large tumor suppressor kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (1240459..1268981, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (1219633..1248173, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Thus AMOT is a direct substrate of Lats1/2 mediating functions of the Hippo pathway in endothelial cell migration and angiogenesis.
Title: Phosphorylation of angiomotin by Lats1/2 kinases inhibits F-actin binding, cell migration, and angiogenesis.
lats genes show distinctly different expression profiles during gastrulation. lats1 is almost ubiquitously expressed through development, and lats2 is more prominently expressed in the non-neural ectoderm region of zebrafish gastrula.
Title: Comparative expression of zebrafish lats1 and lats2 and their implication in gastrulation movements.

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General gene information

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Markers

fc19a05.x1 (e-PCR)
- UniSTS:192909

fc19a05.x1 (e-PCR)
- UniSTS:192910

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_negative_effect BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_negative_effect BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within convergent extension involved in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within convergent extension involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in hippo signaling	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of organ growth	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serine/threonine-protein kinase LATS1

Names: LATS, large tumor suppressor, homolog 1

NP_001018346.1

EC 2.7.11.1

XP_005160369.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001020510.1 → NP_001018346.1 serine/threonine-protein kinase LATS1

See identical proteins and their annotated locations for NP_001018346.1

Status: PROVISIONAL

Source sequence(s)

AY957463

UniProtKB/TrEMBL

Q58FB8

Related

ENSDARP00000157243.1, ENSDART00000189866.1

Conserved Domains (2) summary

smart00220
Location:645 → 950

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:644 → 1024

PKc_like; Protein Kinases, catalytic domain