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st8sia6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 [ Danio rerio (zebrafish) ]

Gene ID: 553212, updated on 4-Jan-2025

Summary

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Official Symbol
st8sia6provided by ZNC
Official Full Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6provided by ZNC
Primary source
ZFIN:ZDB-GENE-060322-9
See related
Ensembl:ENSDARG00000021195 AllianceGenome:ZFIN:ZDB-GENE-060322-9
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fa12f08; fb95c11; siat 8F; wu:fa12f08; wu:fb95c11
Summary
Predicted to enable alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. Acts upstream of or within olfactory nerve formation and olfactory placode morphogenesis. Predicted to be located in Golgi membrane. Is expressed in several structures, including cardiovascular system; central nervous system; myotome; pleuroperitoneal region; and unfertilized egg. Orthologous to human ST8SIA6 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See st8sia6 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (16265502..16282357)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (16115535..16135457)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, beta 1 subunit Neighboring gene ribosomal protein L19 Neighboring gene branched chain keto acid dehydrogenase E1 subunit beta, like Neighboring gene gap junction protein gamma 1 Neighboring gene elongation factor Tu GTP binding domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Developmental regulation of oligosialylation in zebrafish. Chang LY, et al. Glycoconj J, 2009 Apr. PMID 18704683
  2. Novel Zebrafish Mono-α2,8-sialyltransferase (ST8Sia VIII): An Evolutionary Perspective of α2,8-Sialylation. Chang LY, et al. Int J Mol Sci, 2019 Jan 31. PMID 30709055, Free PMC Article
  3. Molecular cloning and characterization of the expression pattern of the zebrafish alpha2, 8-sialyltransferases (ST8Sia) in the developing nervous system. Chang LY, et al. Glycoconj J, 2009 Apr. PMID 18642128
  4. Mapping the expressed glycome and glycosyltransferases of zebrafish liver cells as a relevant model system for glycosylation studies. Vanbeselaere J, et al. J Proteome Res, 2012 Apr 6. PMID 22352757
  5. Systems glycomics of adult zebrafish identifies organ-specific sialylation and glycosylation patterns. Yamakawa N, et al. Nat Commun, 2018 Nov 7. PMID 30405127, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables sialyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within olfactory nerve formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within olfactory placode morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oligosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-2,8-sialyltransferase 8F
Names
alpha-2,8-sialyltransferase ST8Sia VI
XP_021327056.1
XP_683398.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    16265502..16282357
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_678306.10 → XP_683398.2  alpha-2,8-sialyltransferase 8F

    UniProtKB/TrEMBL
    A0A8M9PXN4, F1R0F8
    Related
    ENSDARP00000104838.2, ENSDART00000122519.3
    Conserved Domains (1) summary
    pfam00777
    Location:95 → 351
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394525.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    22945..42705
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021471381.2 → XP_021327056.1  alpha-2,8-sialyltransferase 8F

    UniProtKB/TrEMBL
    A0A8M9PXN4, F1R0F8
    Conserved Domains (1) summary
    pfam00777
    Location:95 → 351
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
Nucleotide Protein Strain
Heading Accession and Version

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