lnx2a ligand of numb-protein X 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lnx2aprovided by ZNC
Official Full Name: ligand of numb-protein X 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060228-2
See related: Ensembl:ENSDARG00000029177 AllianceGenome:ZFIN:ZDB-GENE-060228-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: lnx2
Summary: Enables ubiquitin protein ligase activity. Acts upstream of or within exocrine pancreas development. Is expressed in central nervous system; endoderm; and pancreatic system. Orthologous to human LNX2 (ligand of numb-protein X 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (21646314..21674996, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (21501140..21529822, complement)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that the phenotype characterized by inhibition of exocrine cell differentiation requires inactivation of both ubiquitin ligases Lnx2a and Lnx2b.
Title: Lnx2 ubiquitin ligase is essential for exocrine cell differentiation in the early zebrafish pancreas.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within exocrine pancreas development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within exocrine pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: ligand of Numb protein X 2a

Names: ligand of numb-protein X 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113225.2 → NP_001106696.2 ligand of Numb protein X 2a

Status: VALIDATED

Source sequence(s)

BG305543, BX571696, DT867995, EB950577, EB957408, EH583415, FJ156085

UniProtKB/TrEMBL

A0A8M1NFK9, B6DRF5, F1R5N4

Related

ENSDARP00000046210.5, ENSDART00000046211.8

Conserved Domains (3) summary

smart00228
Location:267 → 353

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:646 → 730

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam13639
Location:49 → 87

zf-RING_2; Ring finger domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007135.7 Reference GRCz11 Primary Assembly

Range

21646314..21674996 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021470169.2 → XP_021325844.1 ligand of Numb protein X 2a isoform X1

UniProtKB/TrEMBL

A0A8M9PLS6, B6DRF5

Conserved Domains (1) summary

cd00992
Location:537 → 621

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...