npm1b nucleophosmin 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: npm1bprovided by ZNC
Official Full Name: nucleophosmin 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-080723-7
See related: Ensembl:ENSDARG00000037675 AllianceGenome:ZFIN:ZDB-GENE-080723-7
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: npm4
Summary: Predicted to enable RNA binding activity. Acts upstream of or within hemopoiesis and regulation of apoptotic process. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including eye; fin bud; hematopoietic cell; hematopoietic stem cell; and somite. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human NPM1 (nucleophosmin 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (5589848..5642399, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (5283014..5335580, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nucleophosmin 1b

Names: nucleophosmin 1b (nucleolar phosphoprotein B23, numatrin); nucleophosmin/nucleoplasmin, 1b; nucleophosmin/nucleoplasmin, 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166155.1 → NP_001159627.1 nucleophosmin 1b

Status: PROVISIONAL

Source sequence(s)

BC093285

UniProtKB/TrEMBL

A0A8M1NVF2, Q566X7

Conserved Domains (2) summary

pfam03066
Location:12 → 118

Nucleoplasmin; Nucleoplasmin

pfam16276
Location:248 → 295

NPM1-C; Nucleophosmin C-terminal domain