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mlf1 myeloid leukemia factor 1 [ Danio rerio (zebrafish) ]

Gene ID: 553527, updated on 9-Dec-2024

Summary

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Official Symbol
mlf1provided by ZNC
Official Full Name
myeloid leukemia factor 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-080917-7
See related
Ensembl:ENSDARG00000077301 AllianceGenome:ZFIN:ZDB-GENE-080917-7
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7152405
Summary
Predicted to be involved in regulation of DNA-templated transcription. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including Kupffer's vesicle; cardiovascular system; mesoderm; musculature system; and sensory system. Orthologous to human MLF1 (myeloid leukemia factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See mlf1 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (1148053..1165082)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (1187250..1201876)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene purinergic receptor P2Y12 Neighboring gene purinergic receptor P2Y13 Neighboring gene G elongation factor, mitochondrial 1 Neighboring gene latexin Neighboring gene major facilitator superfamily domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Disruption of Epidermal Growth Factor Receptor but Not EGF Blocks Follicle Activation in Zebrafish Ovary. Song Y, et al. Front Cell Dev Biol, 2021. PMID 35111746, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
myeloid leukemia factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001326373.1 → NP_001313302.1  myeloid leukemia factor 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    CU861456, EH582504
    UniProtKB/TrEMBL
    A0A2R8PY46, A0A8M1P2L2
    Related
    ENSDARP00000144799.1, ENSDART00000188011.1
    Conserved Domains (1) summary
    pfam10248
    Location:28 → 203
    Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein

  2. NM_001326374.1 → NP_001313303.1  myeloid leukemia factor 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CU861456, EH582504
    UniProtKB/TrEMBL
    A0A8M1P8X0, R4GDQ5
    Related
    ENSDARP00000126610.1, ENSDART00000152466.2
    Conserved Domains (1) summary
    pfam10248
    Location:25 → 200
    Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    1148053..1165082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021481409.2 → XP_021337084.1  myeloid leukemia factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M9QH89
    Conserved Domains (1) summary
    pfam10248
    Location:64 → 195
    Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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