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btbd6b BTB (POZ) domain containing 6b [ Danio rerio (zebrafish) ]

Gene ID: 553533, updated on 12-Sep-2024

Summary

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Official Symbol
btbd6bprovided by ZNC
Official Full Name
BTB (POZ) domain containing 6bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030829-65
See related
Ensembl:ENSDARG00000032369 AllianceGenome:ZFIN:ZDB-GENE-030829-65
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
btbd6; btbd6a; sb:cb776; zgc:152751; si:dkey-11b8.2
Summary
Predicted to be involved in neurogenesis. Predicted to act upstream of or within cell differentiation and nervous system development. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Is expressed in several structures, including myotome; nervous system; neural crest; neural tube; and otic vesicle. Orthologous to human BTBD6 (BTB domain containing 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 20
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (20927827..20932782, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (21028154..21033109, complement)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene creatine kinase, brain b Neighboring gene BRF1 RNA polymerase III transcription initiation factor subunit b Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 3 Neighboring gene rho GTPase-activating protein 1-like Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A feedback loop mediated by degradation of an inhibitor is required to initiate neuronal differentiation. Sobieszczuk DF, et al. Genes Dev, 2010 Jan 15. PMID 20080956, Free PMC Article
  2. Gene expression profiling in zebrafish embryos exposed to diclofenac, an environmental toxicant. De Felice B, et al. Mol Biol Rep, 2012 Mar. PMID 21643954
  3. Reverse genetic analysis of neurogenesis in the zebrafish retina. Pujic Z, et al. Dev Biol, 2006 May 15. PMID 16603149
  4. Genome-wide, whole mount in situ analysis of transcriptional regulators in zebrafish embryos. Armant O, et al. Dev Biol, 2013 Aug 15. PMID 23684812, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Btbd6a promotes the relocation of Plzf from nucleus to cytoplasm and targets Plzf for ubiquitination and degradation
    Title: A feedback loop mediated by degradation of an inhibitor is required to initiate neuronal differentiation.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
BTB/POZ domain-containing protein 6-B
Names
BTB (POZ) domain containing 6
BTB/POZ domain-containing protein 6-A
gacek

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024815.2 → NP_001019986.1  BTB/POZ domain-containing protein 6-B

    See identical proteins and their annotated locations for NP_001019986.1

    Status: PROVISIONAL

    Source sequence(s)
    BX255905
    UniProtKB/Swiss-Prot
    Q5TZE1
    Related
    ENSDARP00000039906.5, ENSDART00000039907.7
    Conserved Domains (4) summary
    smart00225
    Location:81 → 180
    BTB; Broad-Complex, Tramtrack and Bric a brac
    smart00875
    Location:186 → 292
    BACK; BTB And C-terminal Kelch
    pfam00651
    Location:73 → 176
    BTB; BTB/POZ domain
    pfam08005
    Location:337 → 480
    PHR; PHR domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    20927827..20932782 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005160494.5 → XP_005160551.1  BTB/POZ domain-containing protein 6-B isoform X1

    UniProtKB/TrEMBL
    A0A8M2B7L0
    Conserved Domains (4) summary
    smart00225
    Location:134 → 233
    BTB; Broad-Complex, Tramtrack and Bric a brac
    smart00875
    Location:239 → 345
    BACK; BTB And C-terminal Kelch
    pfam00651
    Location:126 → 229
    BTB; BTB/POZ domain
    pfam08005
    Location:390 → 533
    PHR; PHR domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395068.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    105952..110908 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5TZE1.1 GenPept UniProtKB/Swiss-Prot:Q5TZE1

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