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usp7 ubiquitin specific peptidase 7 (herpes virus-associated) [ Danio rerio (zebrafish) ]

Gene ID: 553758, updated on 4-Jan-2025

Summary

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Official Symbol
usp7provided by ZNC
Official Full Name
ubiquitin specific peptidase 7 (herpes virus-associated)provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3656
See related
Ensembl:ENSDARG00000073710 AllianceGenome:ZFIN:ZDB-GENE-030131-3656
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc48f04; wu:fc48f04
Summary
Predicted to enable cysteine-type deubiquitinase activity. Acts upstream of or within cranial skeletal system development. Orthologous to human USP7 (ubiquitin specific peptidase 7). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See usp7 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (27606717..27640823)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (27475865..27509981)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137490601 Neighboring gene HUWE1 associated protein modifying stress responses a Neighboring gene si:ch211-157c3.4 Neighboring gene pentraxin 4, long Neighboring gene chloride channel 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A novel TLX1-driven T-ALL zebrafish model: comparative genomic analysis with other leukemia models. Loontiens S, et al. Leukemia, 2020 Dec. PMID 32591643, Free PMC Article
  2. Importance of deubiquitinases in zebrafish craniofacial development. Tse WKF. Biochem Biophys Res Commun, 2017 Jun 10. PMID 28450118
  3. High-throughput genome editing and phenotyping facilitated by high resolution melting curve analysis. Thomas HR, et al. PLoS One, 2014. PMID 25503746, Free PMC Article
  4. Deubiquitination of Ci/Gli by Usp7/HAUSP Regulates Hedgehog Signaling. Zhou Z, et al. Dev Cell, 2015 Jul 6. PMID 26120032, Free PMC Article
  5. Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. Tse WK, et al. BMC Genomics, 2009 Dec 30. PMID 20040115, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cranial skeletal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 7
XP_005164014.1
XP_009297739.3
XP_009297740.3
XP_009297741.1
XP_021329546.1
XP_691215.4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    27606717..27640823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005163957.4 → XP_005164014.1  ubiquitin carboxyl-terminal hydrolase 7 isoform X3

    UniProtKB/TrEMBL
    A0A8M2BB86, A0A8M3B8A7, F1QUS9
    Related
    ENSDARP00000002502.7, ENSDART00000024453.10
    Conserved Domains (5) summary
    COG5077
    Location:57 → 1108
    COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02659
    Location:213 → 531
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd03772
    Location:68 → 203
    MATH_HAUSP; Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7) family, N-terminal MATH (TRAF-like) domain; composed of proteins similar to human HAUSP, an enzyme that specifically catalyzes the deubiquitylation of p53 and MDM2, hence ...
    pfam12436
    Location:628 → 873
    USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7
    pfam14533
    Location:883 → 1094
    USP7_C2; Ubiquitin-specific protease C-terminal

  2. XM_686123.10 → XP_691215.4  ubiquitin carboxyl-terminal hydrolase 7 isoform X4

    UniProtKB/TrEMBL
    A0A8M3AQW7, A0A8N7UV92, I3ISS5
    Related
    ENSDARP00000125968.1, ENSDART00000150953.3
    Conserved Domains (5) summary
    COG5077
    Location:57 → 1101
    COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02659
    Location:213 → 524
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd03772
    Location:68 → 203
    MATH_HAUSP; Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7) family, N-terminal MATH (TRAF-like) domain; composed of proteins similar to human HAUSP, an enzyme that specifically catalyzes the deubiquitylation of p53 and MDM2, hence ...
    pfam12436
    Location:621 → 866
    USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7
    pfam14533
    Location:876 → 1087
    USP7_C2; Ubiquitin-specific protease C-terminal

  3. XM_021473871.2 → XP_021329546.1  ubiquitin carboxyl-terminal hydrolase 7 isoform X6

    UniProtKB/TrEMBL
    A0A8M3B8A7, A0A8M9Q474
    Conserved Domains (1) summary
    cl02553
    Location:33 → 1084
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

  4. XM_009299466.4 → XP_009297741.1  ubiquitin carboxyl-terminal hydrolase 7 isoform X5

    UniProtKB/TrEMBL
    A0A8M3B0Y8, A0A8M3B8A7
    Conserved Domains (5) summary
    COG5077
    Location:43 → 1094
    COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd02659
    Location:199 → 517
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd03772
    Location:54 → 189
    MATH_HAUSP; Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7) family, N-terminal MATH (TRAF-like) domain; composed of proteins similar to human HAUSP, an enzyme that specifically catalyzes the deubiquitylation of p53 and MDM2, hence ...
    pfam12436
    Location:614 → 859
    USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7
    pfam14533
    Location:869 → 1080
    USP7_C2; Ubiquitin-specific protease C-terminal

  5. XM_009299464.4 → XP_009297739.3  ubiquitin carboxyl-terminal hydrolase 7 isoform X1

    UniProtKB/TrEMBL
    A0A8M3B8A7

  6. XM_009299465.4 → XP_009297740.3  ubiquitin carboxyl-terminal hydrolase 7 isoform X2

    UniProtKB/TrEMBL
    A0A8M3AQW7
Nucleotide Protein Strain
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