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c9 complement component 9 [ Danio rerio (zebrafish) ]

Gene ID: 554141, updated on 2-Nov-2024

Summary

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Official Symbol
c9provided by ZNC
Official Full Name
complement component 9provided by ZNC
Primary source
ZFIN:ZDB-GENE-050522-442
See related
Ensembl:ENSDARG00000016319 AllianceGenome:ZFIN:ZDB-GENE-050522-442
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fb60b05; wu:fd50e04; zgc:112272
Summary
Acts upstream of or within cellular response to estrogen stimulus; defense response to bacterium; and immune response. Predicted to be located in extracellular region; membrane; and other organism cell membrane. Predicted to be part of membrane attack complex. Predicted to be active in extracellular space. Is expressed in liver and yolk syncytial layer. Human ortholog(s) of this gene implicated in age related macular degeneration 15; complement component 9 deficiency; and opiate dependence. Orthologous to human C9 (complement C9). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (32345182..32355145)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (31745029..31754992)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene heat shock protein, alpha-crystallin-related, b15 Neighboring gene DAB adaptor protein 2 Neighboring gene growth arrest-specific 1b Neighboring gene F-box and WD repeat domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification and functional analysis of the perforin-1 like gene in disease resistance in half smooth tongue sole (Cynoglossus semilaevis). Fu X, et al. Dev Comp Immunol, 2021 Sep. PMID 34004267
  2. Molecular Characterization and Expression Analyses of the Complement Component C8α, C8β and C9 Genes in Yellow Catfish (Pelteobagrus fulvidraco) after the Aeromonas hydrophila Challenge. Zheng H, et al. Int J Mol Sci, 2016 Mar 8. PMID 27005612, Free PMC Article
  3. Cell type specific gene expression profiling reveals a role for complement component C3 in neutrophil responses to tissue damage. Houseright RA, et al. Sci Rep, 2020 Sep 24. PMID 32973200, Free PMC Article
  4. Identification of molecular toxicity pathways across early life-stages of zebrafish exposed to PCB126 using a whole transcriptomics approach. Meyer-Alert H, et al. Ecotoxicol Environ Saf, 2021 Jan 15. PMID 33396047
  5. An environmentally relevant concentration of antibiotics impairs the immune system of zebrafish (Danio rerio) and increases susceptibility to virus infection. Pereiro P, et al. Front Immunol, 2022. PMID 36713462, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to estrogen stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in complement activation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within complement activation, alternative pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within defense response to bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within immune response IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within killing of cells of another organism IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of membrane attack complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of membrane attack complex IEA
Inferred from Electronic Annotation
more info
  
located_in other organism cell membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
complement component C9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001327926.1 → NP_001314855.1  complement component C9 precursor

    Status: PROVISIONAL

    Source sequence(s)
    BX510649
    UniProtKB/TrEMBL
    A0A8M1P382, B8A565
    Related
    ENSDARP00000121323.1, ENSDART00000147132.3
    Conserved Domains (3) summary
    smart00209
    Location:633 → 673
    TSP1; Thrombospondin type 1 repeats
    cd00112
    Location:103 → 140
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl02616
    Location:367 → 577
    MACPF; MAC/Perforin domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    32345182..32355145
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001024435.1: Suppressed sequence

    Description
    NM_001024435.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version

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