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DHRS4-AS1 DHRS4 antisense RNA 1 [ Homo sapiens (human) ]

Gene ID: 55449, updated on 10-Dec-2024

Summary

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Official Symbol
DHRS4-AS1provided by HGNC
Official Full Name
DHRS4 antisense RNA 1provided by HGNC
Primary source
HGNC:HGNC:23175
See related
Ensembl:ENSG00000215256 MIM:616925; AllianceGenome:HGNC:23175
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRO1488; AS1DHRS4; C14orf67; DHRS4AS1; C14orf167
Expression
Ubiquitous expression in kidney (RPKM 24.8), duodenum (RPKM 10.1) and 24 other tissues See more
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Genomic context

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See DHRS4-AS1 in Genome Data Viewer
Location:
14q11.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (23938731..23955112, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (18139066..18155444, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24407940..24424321, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene dehydrogenase/reductase 4 like 2 pseudogene Neighboring gene long intergenic non-protein coding RNA 596 Neighboring gene NANOG hESC enhancer GRCh37_chr14:24366856-24367386 Neighboring gene uncharacterized LOC105370411 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8179 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8180 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8181 Neighboring gene uncharacterized LOC124903290 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5614 Neighboring gene dehydrogenase/reductase 4 Neighboring gene dehydrogenase/reductase 4 like 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8182 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5615

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Long non-coding RNA DHRS4 antisense RNA 1 inhibits ectopic endometrial cell proliferation, migration, and invasion in endometriosis by regulating microRNA-139-5p expression. Cui X, et al. Bioengineered, 2022 Apr. PMID 35414313, Free PMC Article
  2. Enhancer RNA-driven looping enhances the transcription of the long noncoding RNA DHRS4-AS1, a controller of the DHRS4 gene cluster. Yang Y, et al. Sci Rep, 2016 Feb 11. PMID 26864944, Free PMC Article
  3. AS1DHRS4, a head-to-head natural antisense transcript, silences the DHRS4 gene cluster in cis and trans. Li Q, et al. Proc Natl Acad Sci U S A, 2012 Aug 28. PMID 22891334, Free PMC Article
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long non-coding RNA DHRS4 antisense RNA 1 inhibits ectopic endometrial cell proliferation, migration, and invasion in endometriosis by regulating microRNA-139-5p expression.
    Title: Long non-coding RNA DHRS4 antisense RNA 1 inhibits ectopic endometrial cell proliferation, migration, and invasion in endometriosis by regulating microRNA-139-5p expression.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

Other Names

  • DHRS4 antisense RNA 1 (non-protein coding)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_023921.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AL136419, BX247982, BX447332, DA439818
    Related
    ENST00000666884.2

  2. NR_023922.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, resulting in a shorter transcript, compared to variant 1.
    Source sequence(s)
    AL136419, BF206895, BX482101
    Related
    ENST00000660207.2

  3. NR_023923.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon structure in the 5' region, resulting in a shorter transcript, compared to variant 1.
    Source sequence(s)
    AL136419, DA439818, DB254318
    Related
    ENST00000555045.4

  4. NR_023924.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' terminal exon, resulting in a shorter transcript, compared to variant 1.
    Source sequence(s)
    AL136419, BC080582, DA439818
    Related
    ENST00000556379.3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    23938731..23955112 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654722.1 Reference GRCh38.p14 PATCHES

    Range
    239710..256091 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    18139066..18155444 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_018583.1: Suppressed sequence

    Description
    NM_018583.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9P1J3.1 GenPept UniProtKB/Swiss-Prot:Q9P1J3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials