crip2 cysteine-rich protein 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: crip2provided by ZNC
Official Full Name: cysteine-rich protein 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2889
See related: Ensembl:ENSDARG00000070670 AllianceGenome:ZFIN:ZDB-GENE-040426-2889
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55408; wu:fb30h10
Summary: Predicted to enable metal ion binding activity. Acts upstream of or within heart contraction and heart development. Is expressed in several structures, including cardiovascular system; mesoderm; nervous system; neural crest; and notochord. Orthologous to human CRIP2 (cysteine rich protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 17

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (37445525..37474633, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (37497940..37527048, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Crip2 plays an important role in atrioventricular valve development by downregulating the expression of extracellular matrix components in the endocardial cushion.
Title: Zebrafish Crip2 plays a critical role in atrioventricular valve development by downregulating the expression of ECM genes in the endocardial cushion.
data suggest a specific role for Wnt3a in the development of cardiac NCCs; propose that this function of wnt3a in r6 is partially mediated by crip2 expression in the premigratory cardiac NCCs, which subsequently affects cardiac function and PA patterning
Title: Wnt3a regulates the development of cardiac neural crest cells by modulating expression of cysteine-rich intestinal protein 2 in rhombomere 6.

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General gene information

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Markers

fb30h10.x1 (e-PCR)
- UniSTS:203108

fi29h10.x1 (e-PCR)
- UniSTS:197223

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: cysteine-rich protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213497.2 → NP_998662.2 cysteine-rich protein 2

Status: VALIDATED

Source sequence(s)

AL929543

UniProtKB/TrEMBL

A0A8M1PFB8, F1QZB0

Related

ENSDARP00000094755.3, ENSDART00000103980.4

Conserved Domains (2) summary

cd09401
Location:124 → 177

LIM_TLP_like; The LIM domains of thymus LIM protein (TLP)

cd09476
Location:5 → 58

LIM1_TLP; The first LIM domain of thymus LIM protein (TLP)