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pdia4 protein disulfide isomerase family A, member 4 [ Danio rerio (zebrafish) ]

Gene ID: 554998, updated on 2-Nov-2024

Summary

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Official Symbol
pdia4provided by ZNC
Official Full Name
protein disulfide isomerase family A, member 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5493
See related
Ensembl:ENSDARG00000018491 AllianceGenome:ZFIN:ZDB-GENE-030131-5493
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cai; fj23a12; zgc:56014; zgc:77773; wu:fd20c07; wu:fj23a12; zgc:113965; zgc:136625
Summary
Predicted to enable protein disulfide isomerase activity. Predicted to be involved in protein folding and response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in cell surface and endoplasmic reticulum. Orthologous to human PDIA4 (protein disulfide isomerase family A member 4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See pdia4 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (17334682..17341458)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (17190263..17197039)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene sperm associated antigen 6 Neighboring gene polycystin 1 like 1, transient receptor potential channel interacting Neighboring gene si:dkey-117j14.6 Neighboring gene enhancer of zeste 2 polycomb repressive complex 2 subunit Neighboring gene cullin 1b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Induction of endoplasmic reticulum stress markers in an acromegaly model. Elbialy A, et al. J Cell Biochem, 2022 Sep. PMID 35734917
  2. Effects of starch-coating of magnetite nanoparticles on cellular uptake, toxicity and gene expression profiles in adult zebrafish. Zheng M, et al. Sci Total Environ, 2018 May 1. PMID 29227944
  3. Toxicity and Transcriptome Sequencing (RNA-seq) Analyses of Adult Zebrafish in Response to Exposure Carboxymethyl Cellulose Stabilized Iron Sulfide Nanoparticles. Zheng M, et al. Sci Rep, 2018 May 24. PMID 29795396, Free PMC Article
  4. A permissive epigenetic landscape facilitates distinct transcriptional signatures of activating transcription factor 6 in the liver. Ramdas Nair A, et al. Genomics, 2022 Jan. PMID 34863900
  5. Whole genome duplications have provided teleosts with many roads to peptide loaded MHC class I molecules. Grimholt U. BMC Evol Biol, 2018 Feb 23. PMID 29471808, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC113965, MGC136625

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein disulfide isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein disulfide isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein disulfide-isomerase A4
Names
calcium binding protein, intestinal
protein disulfide isomerase associated 4
NP_956073.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199779.2 → NP_956073.2  protein disulfide-isomerase A4 precursor

    Status: VALIDATED

    Source sequence(s)
    BC117629, BX005392
    UniProtKB/TrEMBL
    A0A8M1PEJ6, Q1ECX9
    Related
    ENSDARP00000018458.5, ENSDART00000018868.7
    Conserved Domains (5) summary
    cd02995
    Location:523 → 628
    PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
    cd03068
    Location:283 → 389
    PDI_b_ERp72; PDIb family, ERp72 subfamily, first redox inactive TRX-like domain b; ERp72 exhibits both disulfide oxidase and reductase functions like PDI, by catalyzing the formation of disulfide bonds of newly synthesized polypeptides in the ER and acting as ...
    cd03073
    Location:394 → 503
    PDI_b'_ERp72_ERp57; PDIb' family, ERp72 and ERp57 subfamily, second redox inactive TRX-like domain b'; ERp72 and ER57 are involved in oxidative protein folding in the ER, like PDI. They exhibit both disulfide oxidase and reductase functions, by catalyzing the formation of ...
    TIGR01126
    Location:179 → 280
    pdi_dom; protein disulfide-isomerase domain
    TIGR01130
    Location:174 → 640
    ER_PDI_fam; protein disulfide isomerase, eukaryotic

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    17334682..17341458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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