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GPRC5D G protein-coupled receptor class C group 5 member D [ Homo sapiens (human) ]

Gene ID: 55507, updated on 28-Oct-2024

Summary

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Official Symbol
GPRC5Dprovided by HGNC
Official Full Name
G protein-coupled receptor class C group 5 member Dprovided by HGNC
Primary source
HGNC:HGNC:13310
See related
Ensembl:ENSG00000111291 MIM:607437; AllianceGenome:HGNC:13310
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the G protein-coupled receptor family; however, the specific function of this gene has not yet been determined. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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See GPRC5D in Genome Data Viewer
Location:
12p13.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (12940575..12952170, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (12814207..12827419, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (13093509..13105104, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902881 Neighboring gene RPL13AP20-GPRC5A intergenic CAGE-defined mid-level expression enhancer Neighboring gene G protein-coupled receptor class C group 5 member A Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 12:13058787 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 12:13059781 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 12:13073965 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 12:13075202 Neighboring gene microRNA 614 Neighboring gene GPRC5D and HEBP1 antisense RNA 1 Neighboring gene small nucleolar RNA SNORD88 Neighboring gene heme binding protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4269

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. GPRC5D as a novel target for the treatment of multiple myeloma: a narrative review. Rodriguez-Otero P, et al. Blood Cancer J, 2024 Feb 2. PMID 38307865, Free PMC Article
  2. Genetic Basis of Relapse after GPRC5D-Targeted CAR T Cells. Mi X, et al. N Engl J Med, 2023 Oct 12. PMID 37819961
  3. Acquired resistance to a GPRC5D-directed T-cell engager in multiple myeloma is mediated by genetic or epigenetic target inactivation. Derrien J, et al. Nat Cancer, 2023 Nov. PMID 37653140
  4. GPRC5D as a promising therapeutic target in EGFR-wild and immuno-cold non-small cell lung cancer. Mei J, et al. J Transl Med, 2023 Aug 13. PMID 37574551, Free PMC Article
  5. GPRC5D is a promising marker for monitoring the tumor load and to target multiple myeloma cells. Cohen Y, et al. Hematology, 2013 Nov. PMID 23510526

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPRC5D as a novel target for the treatment of multiple myeloma: a narrative review.
    Title: GPRC5D as a novel target for the treatment of multiple myeloma: a narrative review.
  2. Acquired resistance to a GPRC5D-directed T-cell engager in multiple myeloma is mediated by genetic or epigenetic target inactivation.
    Title: Acquired resistance to a GPRC5D-directed T-cell engager in multiple myeloma is mediated by genetic or epigenetic target inactivation.
  3. Genetic Basis of Relapse after GPRC5D-Targeted CAR T Cells.
    Title: Genetic Basis of Relapse after GPRC5D-Targeted CAR T Cells.
  4. GPRC5D as a promising therapeutic target in EGFR-wild and immuno-cold non-small cell lung cancer.
    Title: GPRC5D as a promising therapeutic target in EGFR-wild and immuno-cold non-small cell lung cancer.
  5. GPRC5D in MM cells makes this gene and its encoded surface protein as promising markers for monitoring the tumor load and hopefully also as targets for antimyeloma antibodies.
    Title: GPRC5D is a promising marker for monitoring the tumor load and to target multiple myeloma cells.
  6. Overexpression of G protein-coupled receptor 5D in the bone marrow is associated with poor prognosis in patients with multiple myeloma.
    Title: Overexpression of G protein-coupled receptor 5D in the bone marrow is associated with poor prognosis in patients with multiple myeloma.
  7. Observational study of gene-disease association. (HuGE Navigator)
    Title: L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC129713, MGC129714

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular exosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
G-protein coupled receptor family C group 5 member D
Names
orphan G-protein coupled receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018654.2 → NP_061124.1  G-protein coupled receptor family C group 5 member D

    See identical proteins and their annotated locations for NP_061124.1

    Status: REVIEWED

    Source sequence(s)
    AC007688
    Consensus CDS
    CCDS8658.1
    UniProtKB/Swiss-Prot
    Q3KNV3, Q7Z5J9, Q8TDS6, Q9NZD1
    Related
    ENSP00000228887.1, ENST00000228887.6
    Conserved Domains (2) summary
    cd14964
    Location:22 → 46
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:21 → 267
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    12940575..12952170 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019583.3 → XP_016875072.1  G-protein coupled receptor family C group 5 member D isoform X1

    UniProtKB/Swiss-Prot
    Q9NZD1
    Related
    ENSP00000379624.3, ENST00000396333.3
    Conserved Domains (1) summary
    pfam00003
    Location:75 → 264
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    12814207..12827419 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372460.1 → XP_054228435.1  G-protein coupled receptor family C group 5 member D isoform X2

    UniProtKB/Swiss-Prot
    Q3KNV3, Q7Z5J9, Q8TDS6, Q9NZD1

  2. XM_054372461.1 → XP_054228436.1  G-protein coupled receptor family C group 5 member D isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NZD1.1 GenPept UniProtKB/Swiss-Prot:Q9NZD1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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