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TRIM36 tripartite motif containing 36 [ Homo sapiens (human) ]

Gene ID: 55521, updated on 10-Dec-2024

Summary

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Official Symbol
TRIM36provided by HGNC
Official Full Name
tripartite motif containing 36provided by HGNC
Primary source
HGNC:HGNC:16280
See related
Ensembl:ENSG00000152503 MIM:609317; AllianceGenome:HGNC:16280
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ANPH; ANPH1; RNF98; HAPRIN; RBCC728
Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 36.6), brain (RPKM 4.1) and 4 other tissues See more
Orthologs
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Genomic context

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See TRIM36 in Genome Data Viewer
Location:
5q22.3
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (115124772..115180294, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (115637975..115693508, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (114460469..114515991, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene potassium calcium-activated channel subfamily N member 2 Neighboring gene NANOG hESC enhancer GRCh37_chr5:113590875-113591386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:113613789-113614290 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:113614291-113614790 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:113643487-113644315 Neighboring gene RN7SK pseudogene 89 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:113695880-113696796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16244 Neighboring gene NANOG hESC enhancer GRCh37_chr5:113724412-113724913 Neighboring gene uncharacterized LOC101927078 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22922 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:113880373-113880872 Neighboring gene long intergenic non-protein coding RNA 1957 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:114117551-114118374 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:114118375-114119196 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:114364747-114365486 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:114364005-114364746 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:114368052-114369251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22923 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:114404076-114405275 Neighboring gene Sharpr-MPRA regulatory region 9285 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:114426221-114426720 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:114426721-114427222 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16245 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16246 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22925 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16247 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22926 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22927 Neighboring gene protein geranylgeranyltransferase type I subunit beta Neighboring gene ribosomal protein S2 pseudogene 26

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Cloning and characterisation of the RBCC728/TRIM36 zinc-binding protein from the tumor suppressor gene region at chromosome 5q22.3. Balint I, et al. Gene, 2004 May 12. PMID 15145053
  2. TRIM36 suppresses cell growth and promotes apoptosis in human esophageal squamous cell carcinoma cells by inhibiting Wnt/β-catenin signaling pathway. Zhao B, et al. Hum Cell, 2022 Sep. PMID 35768649
  3. Identification of human HAPRIN potentially involved in the acrosome reaction. Kitamura K, et al. J Androl, 2005 Jul-Aug. PMID 15955891
  4. (TRIM36 hypermethylation is involved in polycyclic aromatic hydrocarbons-induced cell transformation). He Z, et al. Environ Pollut, 2017 Jun. PMID 28359976
  5. TRIM36, a novel androgen-responsive gene, enhances anti-androgen efficacy against prostate cancer by inhibiting MAPK/ERK signaling pathways. Liang C, et al. Cell Death Dis, 2018 Feb 5. PMID 29449534, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FOXA2 Suppression by TRIM36 Exerts Anti-Tumor Role in Colorectal Cancer Via Inducing NRF2/GPX4-Regulated Ferroptosis.
    Title: FOXA2 Suppression by TRIM36 Exerts Anti-Tumor Role in Colorectal Cancer Via Inducing NRF2/GPX4-Regulated Ferroptosis.
  2. Genome-wide association study reveals HSF2, GJA1 and TRIM36 as susceptibility genes for preeclampsia: a community-based population study in Tianjin, China.
    Title: Genome-wide association study reveals HSF2, GJA1 and TRIM36 as susceptibility genes for preeclampsia: a community-based population study in Tianjin, China.
  3. Trigred motif 36 regulates neuroendocrine differentiation of prostate cancer via HK2 ubiquitination and GPx4 deficiency.
    Title: Trigred motif 36 regulates neuroendocrine differentiation of prostate cancer via HK2 ubiquitination and GPx4 deficiency.
  4. TRIM36 enhances lung adenocarcinoma radiosensitivity and inhibits tumorigenesis through promoting RAD51 ubiquitination and antagonizing hsa-miR-376a-5p.
    Title: TRIM36 enhances lung adenocarcinoma radiosensitivity and inhibits tumorigenesis through promoting RAD51 ubiquitination and antagonizing hsa-miR-376a-5p.
  5. TRIM36 suppresses cell growth and promotes apoptosis in human esophageal squamous cell carcinoma cells by inhibiting Wnt/beta-catenin signaling pathway.
    Title: TRIM36 suppresses cell growth and promotes apoptosis in human esophageal squamous cell carcinoma cells by inhibiting Wnt/β-catenin signaling pathway.
  6. TRIM36 is a novel androgen-responsive gene, and it dramatically enhanced the efficacy of anti-androgen drugs against prostate cancer.
    Title: TRIM36, a novel androgen-responsive gene, enhances anti-androgen efficacy against prostate cancer by inhibiting MAPK/ERK signaling pathways.
  7. Results suggest that high expression of TRIM36 is associated with favorable prognosis and that TRIM36 plays a tumor-suppressive role by inhibiting cell proliferation and migration as well as promoting apoptosis in prostate cancer.
    Title: Androgen-responsive tripartite motif 36 enhances tumor-suppressive effect by regulating apoptosis-related pathway in prostate cancer.
  8. aberrant hypermethylation of TRIM36 might be involved in the acquisition of malignant phenotype and could be served as a biomarker for risk assessment of PAHs exposure
    Title: (TRIM36 hypermethylation is involved in polycyclic aromatic hydrocarbons-induced cell transformation).
  9. The siRNA knock down of TRIM36 in HeLa and LN229 cells also led to reduced cell proliferation and increased apoptosis. We suggest that microtubule disruption and disorganized spindles mediated by mutant TRIM36 affect neural cell proliferation during neural tube formation, leading to Anencephaly .
    Title: A homozygous mutation in TRIM36 causes autosomal recessive anencephaly in an Indian family.
  10. TRIM36 is the causative gene for autosomal recessive anencephaly
    Title: A homozygous mutation in TRIM36 causes autosomal recessive anencephaly in an Indian family.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Anencephaly 1
MedGen: C5561928 OMIM: 206500 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of tripartite motif containing 36 (TRIM36) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables alpha-tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acrosome reaction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase TRIM36
Names
RING finger protein 98
RING-type E3 ubiquitin transferase TRIM36
tripartite motif protein 36
tripartite motif-containing protein 36
zinc-binding protein Rbcc728
NP_001017397.1
NP_001017398.1
NP_001287681.1
NP_001287688.1
NP_061170.2
XP_016865110.1
XP_016865111.1
XP_016865112.1
XP_047273316.1
XP_047273317.1
XP_047273318.1
XP_054208879.1
XP_054208880.1
XP_054208881.1
XP_054208882.1
XP_054208883.1
XP_054208884.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017397.2 → NP_001017397.1  E3 ubiquitin-protein ligase TRIM36 isoform 2

    See identical proteins and their annotated locations for NP_001017397.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks several 3' exons, but has a much shorter and alternate 3' segment, as compared to variant 1. The resulting isoform (2) has a much shorter and distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    BC046096
    Consensus CDS
    CCDS34211.1
    UniProtKB/Swiss-Prot
    Q9NQ86
    Related
    ENSP00000368938.2, ENST00000379618.6

  2. NM_001017398.2 → NP_001017398.1  E3 ubiquitin-protein ligase TRIM36 isoform 3

    See identical proteins and their annotated locations for NP_001017398.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks several 3' exons, but has a much shorter and alternate 3' segment, as compared to variant 1. The resulting isoform (3) has a much shorter and distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AC008494, AI142389, BF592910
    Consensus CDS
    CCDS34212.1
    UniProtKB/Swiss-Prot
    Q9NQ86
    Related
    ENSP00000368937.2, ENST00000379617.2

  3. NM_001300752.2 → NP_001287681.1  E3 ubiquitin-protein ligase TRIM36 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an internal exon in the 5' region, which results in translation initiation at a downstream AUG start codon, compared to variant 1. The resulting isoform (4) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AB196558, AC008494, AC094104, AJ272269
    Consensus CDS
    CCDS78047.1
    UniProtKB/TrEMBL
    E9PBG3, Q4R1Q4
    Related
    ENSP00000424259.1, ENST00000514154.1
    Conserved Domains (4) summary
    smart00060
    Location:276 → 336
    FN3; Fibronectin type 3 domain
    cd00021
    Location:56 → 94
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd12894
    Location:360 → 563
    SPRY_PRY_TRIM36; PRY/SPRY domain in tripartite motif-containing protein 36 (TRIM36)
    cl23765
    Location:101 → 225
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  4. NM_001300759.2 → NP_001287688.1  E3 ubiquitin-protein ligase TRIM36 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has an alternate 5' terminal exon, compared to variant 1. The resulting isoform (5) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC094104, AJ272269, AK296389, AK316422
    Consensus CDS
    CCDS75287.1
    UniProtKB/Swiss-Prot
    Q9NQ86
    Related
    ENSP00000423934.1, ENST00000513154.6
    Conserved Domains (5) summary
    smart00060
    Location:419 → 479
    FN3; Fibronectin type 3 domain
    cd00021
    Location:199 → 237
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam13445
    Location:21 → 49
    zf-RING_UBOX; RING-type zinc-finger
    cd12894
    Location:503 → 706
    SPRY_PRY_TRIM36; PRY/SPRY domain in tripartite motif-containing protein 36 (TRIM36)
    cl23765
    Location:244 → 368
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  5. NM_018700.4 → NP_061170.2  E3 ubiquitin-protein ligase TRIM36 isoform 1

    See identical proteins and their annotated locations for NP_061170.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC008494, AC094104, AJ272269
    Consensus CDS
    CCDS4115.1
    UniProtKB/Swiss-Prot
    A1L3Z1, A6NDD0, B7Z3V4, B7ZAV7, E9PFI8, Q0P5Z9, Q9NQ86
    Related
    ENSP00000282369.3, ENST00000282369.7
    Conserved Domains (5) summary
    smart00060
    Location:431 → 491
    FN3; Fibronectin type 3 domain
    cd00021
    Location:211 → 249
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam13445
    Location:33 → 61
    zf-RING_UBOX; RING-type zinc-finger
    cd12894
    Location:515 → 718
    SPRY_PRY_TRIM36; PRY/SPRY domain in tripartite motif-containing protein 36 (TRIM36)
    cl23765
    Location:256 → 380
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    115124772..115180294 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009621.3 → XP_016865110.1  E3 ubiquitin-protein ligase TRIM36 isoform X1

  2. XM_017009622.3 → XP_016865111.1  E3 ubiquitin-protein ligase TRIM36 isoform X2

  3. XM_047417360.1 → XP_047273316.1  E3 ubiquitin-protein ligase TRIM36 isoform X3

  4. XM_047417361.1 → XP_047273317.1  E3 ubiquitin-protein ligase TRIM36 isoform X4

    UniProtKB/TrEMBL
    E9PBG3, Q4R1Q4

  5. XM_017009623.3 → XP_016865112.1  E3 ubiquitin-protein ligase TRIM36 isoform X5

  6. XM_047417362.1 → XP_047273318.1  E3 ubiquitin-protein ligase TRIM36 isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    115637975..115693508 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352904.1 → XP_054208879.1  E3 ubiquitin-protein ligase TRIM36 isoform X1

  2. XM_054352905.1 → XP_054208880.1  E3 ubiquitin-protein ligase TRIM36 isoform X2

  3. XM_054352906.1 → XP_054208881.1  E3 ubiquitin-protein ligase TRIM36 isoform X3

  4. XM_054352907.1 → XP_054208882.1  E3 ubiquitin-protein ligase TRIM36 isoform X4

    UniProtKB/TrEMBL
    Q4R1Q4

  5. XM_054352908.1 → XP_054208883.1  E3 ubiquitin-protein ligase TRIM36 isoform X5

  6. XM_054352909.1 → XP_054208884.1  E3 ubiquitin-protein ligase TRIM36 isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NQ86.2 GenPept UniProtKB/Swiss-Prot:Q9NQ86

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