foxp2 forkhead box P2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: foxp2provided by ZNC
Official Full Name: forkhead box P2provided by ZNC
Primary source: ZFIN:ZDB-GENE-041203-2
See related: Ensembl:ENSDARG00000005453 AllianceGenome:ZFIN:ZDB-GENE-041203-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within gamma-aminobutyric acid signaling pathway; response to ethanol; and swimming behavior. Predicted to be active in nucleus. Is expressed in central nervous system; head; and heart tube. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; autism spectrum disorder (multiple); communication disorder (multiple); dyslexia; and major depressive disorder. Orthologous to human FOXP2 (forkhead box P2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (6420095..6567503, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (6414782..6630967, complement)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our findings suggest that foxP2 is not necessary for axon pathfinding during development.
Title: Zebrafish foxP2 zinc finger nuclease mutant has normal axon pathfinding.
Domain-specific regulation of foxP2 CNS expression by lef1.
Title: Domain-specific regulation of foxP2 CNS expression by lef1.
foxP2 likely has a more general conserved role in nervous system development; molecular cloning
Title: Molecular cloning and developmental expression of foxP2 in zebrafish.
The developing optic tectum becomes the major area of FoxP2 expression. In the adult brain, the highest concentrations of the FoxP2 transcript can be observed in the optic tectum.
Title: Expression of FoxP2 during zebrafish development and in the adult brain.

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General gene information

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Markers

fb97g01.x1 (e-PCR)
- UniSTS:203596

G39348 (e-PCR)
- UniSTS:36209

Z9920 (e-PCR)
- UniSTS:50328

G45612 (e-PCR)
- UniSTS:106414

fc68a02.x1 (e-PCR)
- UniSTS:194234

AW175400 (e-PCR)
- UniSTS:205773

fd48h09.y1 (e-PCR)
- UniSTS:195543

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to ethanol	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within swimming behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: forkhead box protein P2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030082.3 → NP_001025253.1 forkhead box protein P2

See identical proteins and their annotated locations for NP_001025253.1

Status: VALIDATED

Source sequence(s)

CR356233, CT583719, CU468733

UniProtKB/TrEMBL

A0A8M1N755, Q1L9B9, Q4JNX5

Related

ENSDARP00000120014.2, ENSDART00000134820.4

Conserved Domains (2) summary

cd00059
Location:470 → 542

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16159
Location:305 → 372

FOXP-CC; FOXP coiled-coil domain