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acsl1a acyl-CoA synthetase long chain family member 1a [ Danio rerio (zebrafish) ]

Gene ID: 555308, updated on 2-Nov-2024

Summary

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Official Symbol
acsl1aprovided by ZNC
Official Full Name
acyl-CoA synthetase long chain family member 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050809-115
See related
Ensembl:ENSDARG00000030514 AllianceGenome:ZFIN:ZDB-GENE-050809-115
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
acsl1; zgc:110081
Summary
Predicted to enable arachidonate-CoA ligase activity. Predicted to be involved in long-chain fatty acid metabolic process; long-chain fatty-acyl-CoA biosynthetic process; and very long-chain fatty acid metabolic process. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be active in endoplasmic reticulum and membrane. Is expressed in several structures, including digestive system; eye; gill; heart; and pleuroperitoneal region. Orthologous to human ACSL1 (acyl-CoA synthetase long chain family member 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See acsl1a in Genome Data Viewer
Location:
chromosome: 1
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (17537322..17587554, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (16844385..16894630, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene FAT atypical cadherin 1a Neighboring gene caspase 3, apoptosis-related cysteine peptidase a Neighboring gene si:ch211-197n1.2 Neighboring gene helt bHLH transcription factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Diversity and history of the long-chain acyl-CoA synthetase (Acsl) gene family in vertebrates. Lopes-Marques M, et al. BMC Evol Biol, 2013 Dec 12. PMID 24330521, Free PMC Article
  2. Accumulation of Lipid Droplets in a Novel Bietti Crystalline Dystrophy Zebrafish Model With Impaired PPARα Pathway. Gao P, et al. Invest Ophthalmol Vis Sci, 2022 May 2. PMID 35616930, Free PMC Article
  3. Genetic deletion of gpr27 alters acylcarnitine metabolism, insulin sensitivity, and glucose homeostasis in zebrafish. Nath AK, et al. FASEB J, 2020 Jan. PMID 31914600, Free PMC Article
  4. Dysregulatory effects of retinoic acid isomers in late zebrafish embryos. Navarro-Martín L, et al. Environ Sci Pollut Res Int, 2018 Feb. PMID 29178002
  5. Cannabinoid receptor 1 promotes hepatic lipid accumulation and lipotoxicity through the induction of SREBP-1c expression in zebrafish. Pai WY, et al. Transgenic Res, 2013 Aug. PMID 23315130

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC110081

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables arachidonate-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acid-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty-acyl-CoA biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in very long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
long-chain-fatty-acid--CoA ligase 1a
Names
acyl-CoA synthetase long-chain family member 1
NP_001027007.1
XP_005168406.1
XP_005168407.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031837.1 → NP_001027007.1  long-chain-fatty-acid--CoA ligase 1a

    See identical proteins and their annotated locations for NP_001027007.1

    Status: PROVISIONAL

    Source sequence(s)
    BC100000
    UniProtKB/TrEMBL
    Q499A9
    Related
    ENSDARP00000039916.5, ENSDART00000039917.7
    Conserved Domains (2) summary
    PLN02736
    Location:88 → 695
    PLN02736; long-chain acyl-CoA synthetase
    cd05927
    Location:116 → 692
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    17537322..17587554 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005168350.5 → XP_005168407.1  long-chain-fatty-acid--CoA ligase 1a isoform X2

    UniProtKB/TrEMBL
    A0A8M2BFN1
    Conserved Domains (2) summary
    PLN02736
    Location:88 → 695
    PLN02736; long-chain acyl-CoA synthetase
    cd05927
    Location:116 → 692
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  2. XM_005168349.5 → XP_005168406.1  long-chain-fatty-acid--CoA ligase 1a isoform X1

    UniProtKB/TrEMBL
    A0A8M2BFN5, B8JK22
    Related
    ENSDARP00000105676.1, ENSDART00000125125.3
    Conserved Domains (2) summary
    PLN02736
    Location:88 → 695
    PLN02736; long-chain acyl-CoA synthetase
    cd05927
    Location:116 → 692
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394470.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    361970..410943 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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