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vill villin-like [ Danio rerio (zebrafish) ]

Gene ID: 555361, updated on 2-Nov-2024

Summary

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Official Symbol
villprovided by ZNC
Official Full Name
villin-likeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-081222-1
See related
Ensembl:ENSDARG00000001909 AllianceGenome:ZFIN:ZDB-GENE-081222-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable actin filament binding activity. Predicted to act upstream of or within actin filament capping and cytoskeleton organization. Orthologous to human VILL (villin like). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See vill in Genome Data Viewer
Location:
chromosome: 24
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (20418226..20449959, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (20274282..20305540, complement)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene acetyl-CoA acyltransferase 1 Neighboring gene DLEC1 cilia and flagella associated protein Neighboring gene phospholipase C, delta 1a Neighboring gene uncharacterized LOC137489234 Neighboring gene CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like a Neighboring gene microRNA 26a-3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Modelling pancreatic β-cell inflammation in zebrafish identifies the natural product wedelolactone for human islet protection. Delgadillo-Silva LF, et al. Dis Model Mech, 2019 Jan 23. PMID 30679186, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actin filament capping IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
villin-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    20418226..20449959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009297407.4 → XP_009295682.1  villin-like protein isoform X4

    See identical proteins and their annotated locations for XP_009295682.1

    UniProtKB/TrEMBL
    A0A8M3AP84, E7FC92
    Conserved Domains (7) summary
    cd11288
    Location:511 → 601
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:134 → 222
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8 → 118
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:616 → 713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:249 → 346
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:390 → 490
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    pfam02209
    Location:816 → 850
    VHP; Villin headpiece domain

  2. XM_021470314.2 → XP_021325989.1  villin-like protein isoform X3

    UniProtKB/TrEMBL
    A0A8M9PM91
    Conserved Domains (7) summary
    cd11288
    Location:571 → 661
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:194 → 282
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:68 → 178
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:676 → 773
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:309 → 406
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:450 → 550
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    pfam02209
    Location:856 → 890
    VHP; Villin headpiece domain

  3. XM_021470312.2 → XP_021325987.1  villin-like protein isoform X1

    UniProtKB/TrEMBL
    A0A8M9P642
    Conserved Domains (7) summary
    cd11288
    Location:571 → 661
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:194 → 282
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:68 → 178
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:676 → 773
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:309 → 406
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:450 → 550
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    pfam02209
    Location:876 → 910
    VHP; Villin headpiece domain

  4. XM_021470313.2 → XP_021325988.1  villin-like protein isoform X2

    UniProtKB/TrEMBL
    A0A8M9PGD1
    Conserved Domains (7) summary
    cd11288
    Location:564 → 654
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:187 → 275
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:61 → 171
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:669 → 766
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:302 → 399
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:443 → 543
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    pfam02209
    Location:869 → 903
    VHP; Villin headpiece domain

  5. XM_068217194.1 → XP_068073295.1  villin-like protein isoform X4

    Related
    ENSDARP00000048939.5, ENSDART00000048940.7
Nucleotide Protein Strain
Heading Accession and Version

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