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crema cAMP responsive element modulator a [ Danio rerio (zebrafish) ]

Gene ID: 555432, updated on 14-Nov-2024

Summary

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Official Symbol
cremaprovided by ZNC
Official Full Name
cAMP responsive element modulator aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-7031
See related
Ensembl:ENSDARG00000023217 AllianceGenome:ZFIN:ZDB-GENE-030131-7031
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fk66d05; wu:fk66d05; si:dkey-177e13.4
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be part of ATF4-CREB1 transcription factor complex. Is expressed in brain and telencephalon. Orthologous to human CREM (cAMP responsive element modulator). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See crema in Genome Data Viewer
Location:
chromosome: 2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (43159239..43196619, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (43308712..43347236, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487483 Neighboring gene finTRIM family, member 15 Neighboring gene par-3 family cell polarity regulator alpha, b Neighboring gene neuropilin 1b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Inversely Regulated Inflammation-Related Processes Mediate Anxiety-Obesity Links in Zebrafish Larvae and Adults. Yehuda H, et al. Cells, 2023 Jul 6. PMID 37443828, Free PMC Article
  2. A novel regulatory circuit in base excision repair involving AP endonuclease 1, Creb1 and DNA polymerase beta. Pei DS, et al. Nucleic Acids Res, 2011 Apr. PMID 21172930, Free PMC Article
  3. AP endonuclease 1 (Apex1) influences brain development linking oxidative stress and DNA repair. Pei DS, et al. Cell Death Dis, 2019 Apr 25. PMID 31024003, Free PMC Article
  4. Gene responses in the central nervous system of zebrafish embryos exposed to the neurotoxicant methyl mercury. Ho NY, et al. Environ Sci Technol, 2013 Apr 2. PMID 23458150
  5. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cAMP response element binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of ATF4-CREB1 transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cAMP-responsive element modulator
Names
Zfcrem

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    43159239..43196619 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005171403.5 → XP_005171460.1  cAMP-responsive element modulator isoform X2

    UniProtKB/TrEMBL
    A0A8M2BIS5
    Conserved Domains (2) summary
    cd14690
    Location:205 → 259
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:28 → 66
    pKID; pKID domain

  2. XM_677932.10 → XP_683024.3  cAMP-responsive element modulator isoform X1

    See identical proteins and their annotated locations for XP_683024.3

    UniProtKB/TrEMBL
    A0A8N7T6W6, E7F9I0
    Related
    ENSDARP00000116638.1, ENSDART00000141087.2
    Conserved Domains (2) summary
    cd14690
    Location:244 → 298
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:67 → 105
    pKID; pKID domain

  3. XM_068214537.1 → XP_068070638.1  cAMP-responsive element modulator isoform X1

  4. XM_068214533.1 → XP_068070634.1  cAMP-responsive element modulator isoform X1

  5. XM_005171404.5 → XP_005171461.1  cAMP-responsive element modulator isoform X3

    UniProtKB/TrEMBL
    A0A8M2BIR3, E9QD53
    Related
    ENSDARP00000112661.1, ENSDART00000132588.3
    Conserved Domains (1) summary
    cd14690
    Location:54 → 108
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
Nucleotide Protein Strain
Heading Accession and Version

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