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cttnbp2 cortactin binding protein 2 [ Danio rerio (zebrafish) ]

Gene ID: 555837, updated on 2-Nov-2024

Summary

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Official Symbol
cttnbp2provided by ZNC
Official Full Name
cortactin binding protein 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-8134
See related
Ensembl:ENSDARG00000040991 AllianceGenome:ZFIN:ZDB-GENE-030131-8134
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fj55a11; wu:fj55a11; si:dkey-270i2.3
Summary
Predicted to be involved in regulation of synapse organization. Predicted to be located in cell cortex and dendritic spine. Predicted to be active in glutamatergic synapse. Is expressed in anterior macula. Orthologous to human CTTNBP2 (cortactin binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See cttnbp2 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (20725264..20821870, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (20736198..20832829, complement)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat, SAM and basic leucine zipper domain containing 1 Neighboring gene CF transmembrane conductance regulator Neighboring gene uncharacterized LOC137488275 Neighboring gene tetratricopeptide repeat domain 23

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in regulation of synapse organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cortactin-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    20725264..20821870 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021467802.2 → XP_021323477.1  cortactin-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M9P1C3, F1QFV1
    Related
    ENSDARP00000091516.3, ENSDART00000100743.5
    Conserved Domains (7) summary
    cd00204
    Location:679 → 796
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:679 → 707
    ANK; ANK repeat [structural motif]
    pfam09727
    Location:35 → 180
    CortBP2; Cortactin-binding protein-2
    pfam12796
    Location:617 → 707
    Ank_2; Ankyrin repeats (3 copies)
    pfam15991
    Location:216 → 463
    G_path_suppress; G-protein pathway suppressor
    cl25732
    Location:123 → 272
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26464
    Location:400 → 629
    Atrophin-1; Atrophin-1 family

  2. XM_068214902.1 → XP_068071003.1  cortactin-binding protein 2 isoform X2

    Related
    ENSDARP00000119895.1, ENSDART00000143233.2

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395022.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    322622..418397 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_678481.8 → XP_683573.5  cortactin-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8N7T6Y9
    Conserved Domains (7) summary
    cd00204
    Location:679 → 796
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:679 → 707
    ANK; ANK repeat [structural motif]
    pfam09727
    Location:35 → 180
    CortBP2; Cortactin-binding protein-2
    pfam12796
    Location:617 → 707
    Ank_2; Ankyrin repeats (3 copies)
    pfam15991
    Location:216 → 463
    G_path_suppress; G-protein pathway suppressor
    cl25742
    Location:119 → 273
    ERM; Ezrin/radixin/moesin family
    cl26464
    Location:400 → 629
    Atrophin-1; Atrophin-1 family
Nucleotide Protein Strain
Heading Accession and Version

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