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pip4k2ab phosphatidylinositol-5-phosphate 4-kinase, type II, alpha b [ Danio rerio (zebrafish) ]

Gene ID: 555920, updated on 27-Dec-2024

Summary

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Official Symbol
pip4k2abprovided by ZNC
Official Full Name
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070912-272
See related
Ensembl:ENSDARG00000063544 AllianceGenome:ZFIN:ZDB-GENE-070912-272
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-279l9.5
Summary
Predicted to enable 1-phosphatidylinositol-5-phosphate 4-kinase activity and ATP binding activity. Predicted to act upstream of or within phosphatidylinositol metabolic process and phosphorylation. Predicted to be located in lysosome; nucleus; and plasma membrane. Orthologous to human PIP4K2A (phosphatidylinositol-5-phosphate 4-kinase type 2 alpha). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See pip4k2ab in Genome Data Viewer
Location:
chromosome: 2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (21089652..21157069)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (21431439..21499054)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene RIO kinase 1 (yeast) Neighboring gene nebulette Neighboring gene bmi1 polycomb ring finger oncogene 1b Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Role of phosphatidylinositol 5-phosphate 4-kinase α in zebrafish development. Elouarrat D, et al. Int J Biochem Cell Biol, 2013 Jul. PMID 23542014
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 1-phosphatidylinositol-5-phosphate 4-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphatidylinositol metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphatidylinositol 5-phosphate 4-kinase type-2 alpha; phosphatidylinositol 5-phosphate 4-kinase type-2 beta
Names
phosphatidylinositol-5-phosphate 4-kinase, type II, beta
XP_005163424.1
XP_683672.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    21089652..21157069
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005163367.5 → XP_005163424.1  phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1

    UniProtKB/TrEMBL
    A0A8M2BAK4
    Conserved Domains (1) summary
    smart00330
    Location:66 → 444
    PIPKc; Phosphatidylinositol phosphate kinases

  2. XM_678580.9 → XP_683672.2  phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X2

    UniProtKB/TrEMBL
    A0A8N7UUX6, B0UXW0
    Related
    ENSDARP00000113001.1, ENSDART00000139633.4
    Conserved Domains (1) summary
    smart00330
    Location:66 → 412
    PIPKc; Phosphatidylinositol phosphate kinases
Nucleotide Protein
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