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kcnb2a potassium voltage-gated channel subfamily B member 2a [ Danio rerio (zebrafish) ]

Gene ID: 555921, updated on 2-Nov-2024

Summary

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Official Symbol
kcnb2aprovided by ZNC
Official Full Name
potassium voltage-gated channel subfamily B member 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070912-170
See related
Ensembl:ENSDARG00000038862 AllianceGenome:ZFIN:ZDB-GENE-070912-170
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
kcnb2; si:ch211-193n21.1
Summary
Predicted to enable potassium channel regulator activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Predicted to act upstream of or within monoatomic ion transmembrane transport; potassium ion transport; and protein homooligomerization. Predicted to be located in perikaryon. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in dendrite; membrane; and neuronal cell body. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human KCNB2 (potassium voltage-gated channel subfamily B member 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See kcnb2a in Genome Data Viewer
Location:
chromosome: 2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (30144979..30176543)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (30161190..30193938)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene sonic hedgehog signaling molecule b Neighboring gene DnaJ heat shock protein family (Hsp40) member B6a Neighboring gene transient receptor potential cation channel, subfamily A, member 1a Neighboring gene small nucleolar SNORD12/SNORD106 Neighboring gene ribosomal protein L7 Neighboring gene retinol dehydrogenase 10b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
potassium voltage-gated channel subfamily B member 2; potassium voltage-gated channel subfamily B member 2a
Names
potassium voltage-gated channel, Shab-related subfamily, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    30144979..30176543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005163446.5 → XP_005163503.1  potassium voltage-gated channel subfamily B member 2

    See identical proteins and their annotated locations for XP_005163503.1

    UniProtKB/TrEMBL
    A0A8M2BAM8, B0V2U3
    Related
    ENSDARP00000107363.2, ENSDART00000129365.3
    Conserved Domains (5) summary
    smart00225
    Location:36 → 142
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:229 → 427
    Ion_trans; Ion transport protein
    pfam02214
    Location:36 → 135
    BTB_2; BTB/POZ domain
    pfam03521
    Location:473 → 695
    Kv2channel; Kv2 voltage-gated K+ channel
    pfam07885
    Location:340 → 421
    Ion_trans_2; Ion channel

  2. XM_678581.10 → XP_683673.2  potassium voltage-gated channel subfamily B member 2

    See identical proteins and their annotated locations for XP_683673.2

    UniProtKB/TrEMBL
    A0A8M2BAM8, B0V2U3
    Conserved Domains (5) summary
    smart00225
    Location:36 → 142
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:229 → 427
    Ion_trans; Ion transport protein
    pfam02214
    Location:36 → 135
    BTB_2; BTB/POZ domain
    pfam03521
    Location:473 → 695
    Kv2channel; Kv2 voltage-gated K+ channel
    pfam07885
    Location:340 → 421
    Ion_trans_2; Ion channel
Nucleotide Protein Strain
Heading Accession and Version

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