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mknk1 MAPK interacting serine/threonine kinase 1 [ Danio rerio (zebrafish) ]

Gene ID: 555974, updated on 14-Nov-2024

Summary

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Official Symbol
mknk1provided by ZNC
Official Full Name
MAPK interacting serine/threonine kinase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-080220-11
See related
Ensembl:ENSDARG00000018411 AllianceGenome:ZFIN:ZDB-GENE-080220-11
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:171912
Summary
Predicted to enable calcium-dependent protein serine/threonine kinase activity; calcium/calmodulin-dependent protein kinase activity; and calmodulin binding activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation and regulation of translation. Predicted to be active in cytoplasm and nucleus. Orthologous to human MKNK1 (MAPK interacting serine/threonine kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See mknk1 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (13176568..13189751)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (13118898..13132092)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene ELOVL fatty acid elongase 1b Neighboring gene MOB kinase activator 3C Neighboring gene ATP synthase F1 subunit beta Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 11b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RESA identifies mRNA-regulatory sequences at high resolution. Yartseva V, et al. Nat Methods, 2017 Feb. PMID 28024160, Free PMC Article
  2. Comparative transcriptomic profiling of hydrogen peroxide signaling networks in zebrafish and human keratinocytes: Implications toward conservation, migration and wound healing. Lisse TS, et al. Sci Rep, 2016 Feb 5. PMID 26846883, Free PMC Article
  3. Dynamic RNA-protein interactions underlie the zebrafish maternal-to-zygotic transition. Despic V, et al. Genome Res, 2017 Jul. PMID 28381614, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC171912

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
MAP kinase-interacting serine/threonine-protein kinase 1
Names
MAP kinase interacting serine/threonine kinase 1
NP_001108211.2
XP_005156011.1
XP_005156012.1
XP_005156013.1
XP_068080274.1
XP_068080275.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114739.2 → NP_001108211.2  MAP kinase-interacting serine/threonine-protein kinase 1

    Status: VALIDATED

    Source sequence(s)
    CR847923
    UniProtKB/TrEMBL
    A0A8M1NGA1, F1QJV2
    Related
    ENSDARP00000111297.1, ENSDART00000125371.3
    Conserved Domains (2) summary
    smart00220
    Location:100 → 380
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14174
    Location:93 → 381
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    13176568..13189751
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005155954.5 → XP_005156011.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B223
    Conserved Domains (2) summary
    smart00220
    Location:102 → 411
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:95 → 412
    PKc_like; Protein Kinases, catalytic domain

  2. XM_005155956.5 → XP_005156013.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X3

    UniProtKB/TrEMBL
    A0A8M2B2B7
    Conserved Domains (2) summary
    smart00220
    Location:102 → 382
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14174
    Location:95 → 383
    STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

  3. XM_068224173.1 → XP_068080274.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X3

  4. XM_005155955.5 → XP_005156012.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M2B1Y9
    Conserved Domains (2) summary
    smart00220
    Location:100 → 409
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:93 → 410
    PKc_like; Protein Kinases, catalytic domain

  5. XM_068224174.1 → XP_068080275.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X4

Nucleotide Protein
Heading Accession and Version

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