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ZDHHC7 zinc finger DHHC-type palmitoyltransferase 7 [ Homo sapiens (human) ]

Gene ID: 55625, updated on 2-Nov-2024

Summary

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Official Symbol
ZDHHC7provided by HGNC
Official Full Name
zinc finger DHHC-type palmitoyltransferase 7provided by HGNC
Primary source
HGNC:HGNC:18459
See related
Ensembl:ENSG00000153786 MIM:614604; AllianceGenome:HGNC:18459
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DHHC7; SERZ1; SERZ-B; ZNF370
Summary
Enables protein-cysteine S-palmitoyltransferase activity. Involved in several processes, including nuclear receptor-mediated steroid hormone signaling pathway; regulation of protein localization; and regulation of signal transduction. Located in Golgi apparatus and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bone marrow (RPKM 20.6), lung (RPKM 20.0) and 25 other tissues See more
Orthologs
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Genomic context

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See ZDHHC7 in Genome Data Viewer
Location:
16q24.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (84974175..85027631, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (91040795..91094281, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (85007781..85045141, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene interferon induced transmembrane protein pseudogene Neighboring gene long intergenic non-protein coding RNA 2176 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:84981710-84982210 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:84982211-84982711 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:85009937-85011136 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85028227-85028727 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85038209-85038959 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7796 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:85045288-85046044 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11257 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7797 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7798 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85068709-85069209 Neighboring gene KIAA0513 Neighboring gene Sharpr-MPRA regulatory region 15308 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85100891-85101391 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85110035-85110590 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11259 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85111701-85112255 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85115357-85116184 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85116185-85117012 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:85117013-85117838 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7799 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85121851-85122676 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:85124326-85125149 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11262 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11263 Neighboring gene CBY1 interacting BAR domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Palmitoyl acyltransferase ZDHHC7 inhibits androgen receptor and suppresses prostate cancer. Lin Z, et al. Oncogene, 2023 Jun. PMID 37198397
  2. Fas palmitoylation by the palmitoyl acyltransferase DHHC7 regulates Fas stability. Rossin A, et al. Cell Death Differ, 2015 Apr. PMID 25301068, Free PMC Article
  3. Deficiency of the palmitoyl acyltransferase ZDHHC7 impacts brain and behavior of mice in a sex-specific manner. Hohoff C, et al. Brain Struct Funct, 2019 Jul. PMID 31183559
  4. Palmitoylation of caveolin-1 is regulated by the same DHHC acyltransferases that modify steroid hormone receptors. Tonn Eisinger KR, et al. J Biol Chem, 2018 Oct 12. PMID 30158247, Free PMC Article
  5. S-Palmitoylation of Junctional Adhesion Molecule C Regulates Its Tight Junction Localization and Cell Migration. Aramsangtienchai P, et al. J Biol Chem, 2017 Mar 31. PMID 28196865, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Palmitoyl acyltransferase ZDHHC7 inhibits androgen receptor and suppresses prostate cancer.
    Title: Palmitoyl acyltransferase ZDHHC7 inhibits androgen receptor and suppresses prostate cancer.
  2. demonstrated the importance of Zdhhc7 for assembling proper brain structure, function, and behavior on a system level in mice in a sex-related manner
    Title: Deficiency of the palmitoyl acyltransferase ZDHHC7 impacts brain and behavior of mice in a sex-specific manner.
  3. identified DHHC7 as a JAM-C palmitoylating enzyme
    Title: S-Palmitoylation of Junctional Adhesion Molecule C Regulates Its Tight Junction Localization and Cell Migration.
  4. The ZDHHC7-mediated SCRIB palmitoylation is critical for SCRIB membrane targeting, cell polarity and tumor suppression, providing new mechanistic insights of how dynamic protein palmitoylation regulates cell polarity and tumorigenesis.
    Title: ZDHHC7-mediated S-palmitoylation of Scribble regulates cell polarity.
  5. DHHC7-mediated palmitoylation of Fas allows a proper Fas expression level by preventing its degradation through the lysosomes.
    Title: Fas palmitoylation by the palmitoyl acyltransferase DHHC7 regulates Fas stability.
  6. the DHHC-7 and -21 proteins are novel targets to selectively inhibit membrane sex steroid receptor localization and function
    Title: DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Many sequence variants affecting diversity of adult human height.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10792, FLJ20279

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-cysteine S-myristoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-cysteine S-palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-cysteine S-palmitoyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein-cysteine S-palmitoyltransferase activity TAS
Traceable Author Statement
more info
  
enables protein-cysteine S-stearoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in androgen receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glucose import in response to insulin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-L-cysteine S-palmitoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-L-cysteine S-palmitoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in polarized epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in progesterone receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein palmitoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein palmitoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of Fas signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein localization to cell-cell junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in steroid hormone receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
palmitoyltransferase ZDHHC7
Names
DHHC-7
Sertoli cell gene with zinc finger domain-I(2)
Sertoli cell gene with zinc finger domain-beta
acyltransferase ZDHHC7
zinc finger DHHC domain-containing protein 7
zinc finger DHHC-type containing 7
zinc finger protein 370
zinc finger, DHHC domain containing 7
NP_001139020.1
NP_060210.2
XP_011521524.1
XP_024306111.1
XP_047290306.1
XP_047290307.1
XP_047290308.1
XP_047290309.1
XP_047290310.1
XP_047290311.1
XP_047290312.1
XP_047290313.1
XP_047290314.1
XP_054169420.1
XP_054169421.1
XP_054169422.1
XP_054169423.1
XP_054169424.1
XP_054169425.1
XP_054169426.1
XP_054169427.1
XP_054169428.1
XP_054169429.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145548.2 → NP_001139020.1  palmitoyltransferase ZDHHC7 isoform 1

    See identical proteins and their annotated locations for NP_001139020.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC092341, AW235073, BC018772, DA507340
    Consensus CDS
    CCDS45538.1
    UniProtKB/Swiss-Prot
    Q9NXF8
    Related
    ENSP00000456782.1, ENST00000564466.5
    Conserved Domains (1) summary
    pfam01529
    Location:168 → 295
    zf-DHHC; DHHC palmitoyltransferase

  2. NM_017740.3 → NP_060210.2  palmitoyltransferase ZDHHC7 isoform 2

    See identical proteins and their annotated locations for NP_060210.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a coding exon but maintains the reading frame compared to variant 1. The resulting isoform (2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC092341, AK000286, AW235073, CN427219, DA507340
    Consensus CDS
    CCDS10950.1
    UniProtKB/Swiss-Prot
    D3DUM1, Q8WV42, Q9NVD8, Q9NXF8
    Related
    ENSP00000315604.5, ENST00000313732.9
    Conserved Domains (1) summary
    pfam01529
    Location:131 → 258
    DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    84974175..85027631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434355.1 → XP_047290311.1  palmitoyltransferase ZDHHC7 isoform X2

    UniProtKB/Swiss-Prot
    D3DUM1, Q8WV42, Q9NVD8, Q9NXF8

  2. XM_047434352.1 → XP_047290308.1  palmitoyltransferase ZDHHC7 isoform X1

  3. XM_047434353.1 → XP_047290309.1  palmitoyltransferase ZDHHC7 isoform X2

    UniProtKB/Swiss-Prot
    D3DUM1, Q8WV42, Q9NVD8, Q9NXF8

  4. XM_047434350.1 → XP_047290306.1  palmitoyltransferase ZDHHC7 isoform X1

  5. XM_047434356.1 → XP_047290312.1  palmitoyltransferase ZDHHC7 isoform X2

    UniProtKB/Swiss-Prot
    D3DUM1, Q8WV42, Q9NVD8, Q9NXF8

  6. XM_047434354.1 → XP_047290310.1  palmitoyltransferase ZDHHC7 isoform X2

    UniProtKB/Swiss-Prot
    D3DUM1, Q8WV42, Q9NVD8, Q9NXF8

  7. XM_047434351.1 → XP_047290307.1  palmitoyltransferase ZDHHC7 isoform X1

  8. XM_024450343.2 → XP_024306111.1  palmitoyltransferase ZDHHC7 isoform X2

    UniProtKB/Swiss-Prot
    D3DUM1, Q8WV42, Q9NVD8, Q9NXF8
    Conserved Domains (1) summary
    pfam01529
    Location:131 → 258
    DHHC; DHHC palmitoyltransferase

  9. XM_047434358.1 → XP_047290314.1  palmitoyltransferase ZDHHC7 isoform X4

  10. XM_047434357.1 → XP_047290313.1  palmitoyltransferase ZDHHC7 isoform X3

  11. XM_011523222.3 → XP_011521524.1  palmitoyltransferase ZDHHC7 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    91040795..91094281 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054313449.1 → XP_054169424.1  palmitoyltransferase ZDHHC7 isoform X2

    UniProtKB/Swiss-Prot
    D3DUM1, Q8WV42, Q9NVD8, Q9NXF8

  2. XM_054313447.1 → XP_054169422.1  palmitoyltransferase ZDHHC7 isoform X2

    UniProtKB/Swiss-Prot
    D3DUM1, Q8WV42, Q9NVD8, Q9NXF8

  3. XM_054313445.1 → XP_054169420.1  palmitoyltransferase ZDHHC7 isoform X1

  4. XM_054313450.1 → XP_054169425.1  palmitoyltransferase ZDHHC7 isoform X2

    UniProtKB/Swiss-Prot
    D3DUM1, Q8WV42, Q9NVD8, Q9NXF8

  5. XM_054313446.1 → XP_054169421.1  palmitoyltransferase ZDHHC7 isoform X1

  6. XM_054313448.1 → XP_054169423.1  palmitoyltransferase ZDHHC7 isoform X2

    UniProtKB/Swiss-Prot
    D3DUM1, Q8WV42, Q9NVD8, Q9NXF8

  7. XM_054313451.1 → XP_054169426.1  palmitoyltransferase ZDHHC7 isoform X2

    UniProtKB/Swiss-Prot
    D3DUM1, Q8WV42, Q9NVD8, Q9NXF8

  8. XM_054313453.1 → XP_054169428.1  palmitoyltransferase ZDHHC7 isoform X4

  9. XM_054313454.1 → XP_054169429.1  palmitoyltransferase ZDHHC7 isoform X4

  10. XM_054313452.1 → XP_054169427.1  palmitoyltransferase ZDHHC7 isoform X3

RNA

  1. XR_008484706.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NXF8.2 GenPept UniProtKB/Swiss-Prot:Q9NXF8

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