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aldh18a1 aldehyde dehydrogenase 18 family, member A1 [ Danio rerio (zebrafish) ]

Gene ID: 557186, updated on 4-Jan-2025

Summary

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Official Symbol
aldh18a1provided by ZNC
Official Full Name
aldehyde dehydrogenase 18 family, member A1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5602
See related
Ensembl:ENSDARG00000099579 AllianceGenome:ZFIN:ZDB-GENE-030131-5602
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
pycs; cb842; cb899; sb:cb881; wu:fa91f10; wu:fi05f11; wu:fi17d12
Summary
Predicted to enable ATP binding activity; glutamate 5-kinase activity; and glutamate-5-semialdehyde dehydrogenase activity. Predicted to be involved in L-proline biosynthetic process. Predicted to act upstream of or within phosphorylation and proline biosynthetic process. Predicted to be located in cytoplasm. Is expressed in several structures, including central nervous system; endocrine system; eye; immature eye; and tail bud. Human ortholog(s) of this gene implicated in cataract; cutis laxa (multiple); enterocele; and hereditary spastic paraplegia (multiple). Orthologous to human ALDH18A1 (aldehyde dehydrogenase 18 family member A1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See aldh18a1 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (30788904..30808933)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (30673986..30694031)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member F3a Neighboring gene ectonucleoside triphosphate diphosphohydrolase 1 Neighboring gene crystallin, gamma MX Neighboring gene crystallin, gamma MX, like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. ALDH2 mediates 5-nitrofuran activity in multiple species. Zhou L, et al. Chem Biol, 2012 Jul 27. PMID 22840776, Free PMC Article
  2. Aldh2 is a lineage-specific metabolic gatekeeper in melanocyte stem cells. Brunsdon H, et al. Development, 2022 May 15. PMID 35485397, Free PMC Article
  3. ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma. Lu Y, et al. Cell Rep, 2024 Jul 23. PMID 38963759, Free PMC Article
  4. A DEAB-sensitive aldehyde dehydrogenase regulates hematopoietic stem and progenitor cells development during primitive hematopoiesis in zebrafish embryos. Ma AC, et al. Leukemia, 2010 Dec. PMID 20927131
  5. Elevated 4-hydroxynonenal induces hyperglycaemia via Aldh3a1 loss in zebrafish and associates with diabetes progression in humans. Lou B, et al. Redox Biol, 2020 Oct. PMID 32980661, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC162616

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables glutamate 5-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutamate-5-semialdehyde dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-proline biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proline biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
delta-1-pyrroline-5-carboxylate synthase
Names
glutamate gamma-semialdehyde synthetase
pyrroline-5-carboxylate synthetase
NP_001077015.1
XP_009305061.1
XP_009305062.1
XP_068080700.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083546.3 → NP_001077015.1  delta-1-pyrroline-5-carboxylate synthase

    See identical proteins and their annotated locations for NP_001077015.1

    Status: VALIDATED

    Source sequence(s)
    CR354534, CR751608
    UniProtKB/TrEMBL
    A0A8M1NCI1, A4IGC8, F1QBM9
    Related
    ENSDARP00000137162.1, ENSDART00000160422.2
    Conserved Domains (3) summary
    TIGR01092
    Location:44 → 773
    P5CS; delta l-pyrroline-5-carboxylate synthetase
    cd07079
    Location:344 → 749
    ALDH_F18-19_ProA-GPR; Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19
    cd04256
    Location:43 → 334
    AAK_P5CS_ProBA; AAK_P5CS_ProBA: Glutamate-5-kinase (G5K) domain of the bifunctional delta 1-pyrroline-5-carboxylate synthetase (P5CS), composed of an N-terminal G5K (ProB) and a C-terminal glutamyl 5- phosphate reductase (G5PR, ProA), the first and second enzyme ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    30788904..30808933
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009306786.4 → XP_009305061.1  delta-1-pyrroline-5-carboxylate synthase isoform X1

    UniProtKB/TrEMBL
    A0A8M3B4R7
    Conserved Domains (3) summary
    TIGR01092
    Location:67 → 796
    P5CS; delta l-pyrroline-5-carboxylate synthetase
    cd07079
    Location:367 → 772
    ALDH_F18-19_ProA-GPR; Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19
    cd04256
    Location:66 → 357
    AAK_P5CS_ProBA; AAK_P5CS_ProBA: Glutamate-5-kinase (G5K) domain of the bifunctional delta 1-pyrroline-5-carboxylate synthetase (P5CS), composed of an N-terminal G5K (ProB) and a C-terminal glutamyl 5- phosphate reductase (G5PR, ProA), the first and second enzyme ...

  2. XM_009306787.4 → XP_009305062.1  delta-1-pyrroline-5-carboxylate synthase isoform X2

    UniProtKB/TrEMBL
    A0A8M3AYJ5
    Conserved Domains (3) summary
    TIGR01092
    Location:67 → 794
    P5CS; delta l-pyrroline-5-carboxylate synthetase
    cd07079
    Location:365 → 770
    ALDH_F18-19_ProA-GPR; Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19
    cd04256
    Location:66 → 355
    AAK_P5CS_ProBA; AAK_P5CS_ProBA: Glutamate-5-kinase (G5K) domain of the bifunctional delta 1-pyrroline-5-carboxylate synthetase (P5CS), composed of an N-terminal G5K (ProB) and a C-terminal glutamyl 5- phosphate reductase (G5PR, ProA), the first and second enzyme ...

  3. XM_068224599.1 → XP_068080700.1  delta-1-pyrroline-5-carboxylate synthase isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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