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ZNF83 zinc finger protein 83 [ Homo sapiens (human) ]

Gene ID: 55769, updated on 2-Nov-2024

Summary

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Official Symbol
ZNF83provided by HGNC
Official Full Name
zinc finger protein 83provided by HGNC
Primary source
HGNC:HGNC:13158
See related
Ensembl:ENSG00000167766 MIM:194558; AllianceGenome:HGNC:13158
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HPF1; ZNF816B
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal (RPKM 32.1), prostate (RPKM 31.2) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF83 in Genome Data Viewer
Location:
19q13.41
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (52612377..52690496, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (55696827..55774933, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53115630..53193749, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 808 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53072140-53072749 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53073969-53074577 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15051 Neighboring gene ribosomal protein L39 pseudogene 34 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:53091538-53091757 Neighboring gene zinc finger protein 701 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10995 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53104606-53105112 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15054 Neighboring gene zinc finger protein 137, pseudogene Neighboring gene zinc finger protein 677-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53140536-53141054 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53141055-53141572 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10996 Neighboring gene Sharpr-MPRA regulatory region 1800 Neighboring gene Zinc finger protein LOC122539214 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:53167404-53167904 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53171845-53172346 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:53172853-53174052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:53177263-53177762 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53179336-53179900 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:53179901-53180465 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53192883-53193418 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10997 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53196613-53197148 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53199383-53200194 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53201006-53201816 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53201817-53202627 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:53219681-53220253 Neighboring gene zinc finger protein 611 Neighboring gene uncharacterized LOC124904760 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:53238285-53239270 Neighboring gene uncharacterized LOC105372452

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Recurrent ZNF83-E293V Mutation Promotes Bladder Cancer Progression through the NF-κB Pathway via Transcriptional Dysregulation of S100A8. Lyu ZJ, et al. Mol Ther, 2021 Jan 6. PMID 33002420, Free PMC Article
  2. Assignment of the human ZNF83 (HPF1) zinc finger gene to chromosome 19q13.3-q13.4. Marine JC, et al. Genomics, 1994 May 1. PMID 8088807
  3. The human genome contains hundreds of genes coding for finger proteins of the Krüppel type. Bellefroid EJ, et al. DNA, 1989 Jul-Aug. PMID 2505992
  4. Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency. Bajrami I, et al. Commun Biol, 2021 Nov 8. PMID 34750509, Free PMC Article
  5. Screening of hepatocyte proteins binding to F protein of hepatitis C virus by yeast two-hybrid system. Huang YP, et al. World J Gastroenterol, 2005 Sep 28. PMID 16237761, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11015, FLJ14876, FLJ30097, FLJ90585, MGC33853

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 83
Names
zinc finger protein 816B
zinc finger protein HPF1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052996.1 RefSeqGene

    Range
    5001..83218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001105549.2 → NP_001099019.1  zinc finger protein 83

    See identical proteins and their annotated locations for NP_001099019.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the supported protein. All variants (1-5 and 10-21) encode the same protein.
    Source sequence(s)
    AA883993, BC032867, BG260506, BG741860, BX641726, DA107683, DA183557, DB107467
    Consensus CDS
    CCDS12854.1
    UniProtKB/Swiss-Prot
    A8MT75, P51522, Q3ZCX0, Q6PI08
    Conserved Domains (2) summary
    COG5048
    Location:117 → 507
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:263 → 283
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001105550.2 → NP_001099020.1  zinc finger protein 83

    See identical proteins and their annotated locations for NP_001099020.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. All variants (1-5 and 10-21) encode the same protein.
    Source sequence(s)
    AA883993, BG260506, BG741860, DA107683, DA151844, DA183557, DB107467
    Consensus CDS
    CCDS12854.1
    UniProtKB/Swiss-Prot
    A8MT75, P51522, Q3ZCX0, Q6PI08
    Related
    ENSP00000516274.2, ENST00000706199.2
    Conserved Domains (2) summary
    COG5048
    Location:117 → 507
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:263 → 283
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001105551.2 → NP_001099021.1  zinc finger protein 83

    See identical proteins and their annotated locations for NP_001099021.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. All variants (1-5 and 10-21) encode the same protein.
    Source sequence(s)
    AA883993, BG260506, BG741860, DA107683, DB107467, DB252431
    Consensus CDS
    CCDS12854.1
    UniProtKB/Swiss-Prot
    A8MT75, P51522, Q3ZCX0, Q6PI08
    Related
    ENSP00000473096.2, ENST00000597161.7
    Conserved Domains (2) summary
    COG5048
    Location:117 → 507
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:263 → 283
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_001105552.2 → NP_001099022.1  zinc finger protein 83

    See identical proteins and their annotated locations for NP_001099022.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. All variants (1-5 and 10-21) encode the same protein.
    Source sequence(s)
    AA883993, BG260506, BG741860, DA107683, DA449506, DB107467
    Consensus CDS
    CCDS12854.1
    UniProtKB/Swiss-Prot
    A8MT75, P51522, Q3ZCX0, Q6PI08
    Related
    ENSP00000445993.3, ENST00000536937.7
    Conserved Domains (2) summary
    COG5048
    Location:117 → 507
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:263 → 283
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. NM_001277945.2 → NP_001264874.1  zinc finger protein 83

    See identical proteins and their annotated locations for NP_001264874.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR, compared to variant 1. All variants (1-5 and 10-21) encode the same protein.
    Source sequence(s)
    AA883993, AK075066, BC013321, BG399319, DA258790, DA380756
    Consensus CDS
    CCDS12854.1
    UniProtKB/Swiss-Prot
    A8MT75, P51522, Q3ZCX0, Q6PI08
    Conserved Domains (2) summary
    COG5048
    Location:117 → 507
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:263 → 283
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. NM_001277946.2 → NP_001264875.1  zinc finger protein 83

    See identical proteins and their annotated locations for NP_001264875.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR, compared to variant 1. All variants (1-5 and 10-21) encode the same protein.
    Source sequence(s)
    AA883993, AK289399, BC013321, BG399319, DA258790, DA380756, DA434207, DB254966
    Consensus CDS
    CCDS12854.1
    UniProtKB/Swiss-Prot
    A8MT75, P51522, Q3ZCX0, Q6PI08
    Conserved Domains (2) summary
    COG5048
    Location:117 → 507
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:263 → 283
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. NM_001277947.2 → NP_001264876.1  zinc finger protein 83

    See identical proteins and their annotated locations for NP_001264876.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR, compared to variant 1. All variants (1-5 and 10-21) encode the same protein.
    Source sequence(s)
    AA883993, AC022150, AK075066, BC013321, BG399319, DA258790, DA380756, DA701045, DT216882
    Consensus CDS
    CCDS12854.1
    UniProtKB/Swiss-Prot
    A8MT75, P51522, Q3ZCX0, Q6PI08
    Conserved Domains (2) summary
    COG5048
    Location:117 → 507
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:263 → 283
    ZF_C2H2; C2H2 Zn finger [structural motif]

  8. NM_001277948.2 → NP_001264877.1  zinc finger protein 83

    See identical proteins and their annotated locations for NP_001264877.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR, compared to variant 1. All variants (1-5 and 10-21) encode the same protein.
    Source sequence(s)
    AA883993, AK075066, BC013321, BG399319, DA258790, DA380756, DB134270, DB272526
    Consensus CDS
    CCDS12854.1
    UniProtKB/Swiss-Prot
    A8MT75, P51522, Q3ZCX0, Q6PI08
    Conserved Domains (2) summary
    COG5048
    Location:117 → 507
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:263 → 283
    ZF_C2H2; C2H2 Zn finger [structural motif]

  9. NM_001277949.2 → NP_001264878.1  zinc finger protein 83

    See identical proteins and their annotated locations for NP_001264878.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) differs in the 5' UTR, compared to variant 1. All variants (1-5 and 10-21) encode the same protein.
    Source sequence(s)
    AA883993, AC022150, AK075066, BC013321, BG399319, DA258790, DA380756, DA434207
    Consensus CDS
    CCDS12854.1
    UniProtKB/Swiss-Prot
    A8MT75, P51522, Q3ZCX0, Q6PI08
    Conserved Domains (2) summary
    COG5048
    Location:117 → 507
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:263 → 283
    ZF_C2H2; C2H2 Zn finger [structural motif]

  10. NM_001277951.2 → NP_001264880.1  zinc finger protein 83

    See identical proteins and their annotated locations for NP_001264880.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15) differs in the 5' UTR, compared to variant 1. All variants (1-5 and 10-21) encode the same protein.
    Source sequence(s)
    AA883993, AC022150, BC013321, DA258790, DA380756, DA731895
    Consensus CDS
    CCDS12854.1
    UniProtKB/Swiss-Prot
    A8MT75, P51522, Q3ZCX0, Q6PI08
    Related
    ENSP00000440713.1, ENST00000545872.1
    Conserved Domains (2) summary
    COG5048
    Location:117 → 507
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:263 → 283
    ZF_C2H2; C2H2 Zn finger [structural motif]

  11. NM_001277952.2 → NP_001264881.1  zinc finger protein 83

    See identical proteins and their annotated locations for NP_001264881.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16) differs in the 5' UTR, compared to variant 1. All variants (1-5 and 10-21) encode the same protein.
    Source sequence(s)
    AA883993, BC013321, DA258790, DA341245, DA380756
    Consensus CDS
    CCDS12854.1
    UniProtKB/Swiss-Prot
    A8MT75, P51522, Q3ZCX0, Q6PI08
    Conserved Domains (2) summary
    COG5048
    Location:117 → 507
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:263 → 283
    ZF_C2H2; C2H2 Zn finger [structural motif]

  12. NM_001348015.2 → NP_001334944.1  zinc finger protein 83

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17) differs in the 5' UTR, compared to variant 1. All variants (1-5 and 10-21) encode the same protein.
    Source sequence(s)
    AA883993, AK075066, BC013321, BG399319, BX641726, DA258790, DA380756
    Consensus CDS
    CCDS12854.1
    UniProtKB/Swiss-Prot
    A8MT75, P51522, Q3ZCX0, Q6PI08
    Conserved Domains (2) summary
    COG5048
    Location:117 → 507
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:263 → 283
    ZF_C2H2; C2H2 Zn finger [structural motif]

  13. NM_001348016.2 → NP_001334945.1  zinc finger protein 83

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18) differs in the 5' UTR, compared to variant 1. All variants (1-5 and 10-21) encode the same protein.
    Source sequence(s)
    AA883993, AC022150, AK075066, BC013321, DA258790, DA380756, DA731895
    Consensus CDS
    CCDS12854.1
    UniProtKB/Swiss-Prot
    A8MT75, P51522, Q3ZCX0, Q6PI08
    Conserved Domains (2) summary
    COG5048
    Location:117 → 507
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:263 → 283
    ZF_C2H2; C2H2 Zn finger [structural motif]

  14. NM_001348017.2 → NP_001334946.1  zinc finger protein 83

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19) differs in the 5' UTR, compared to variant 1. All variants (1-5 and 10-21) encode the same protein.
    Source sequence(s)
    AA883993, AC022150, AK075066, BC013321, BG399319, DA258790, DA380756
    Consensus CDS
    CCDS12854.1
    UniProtKB/Swiss-Prot
    A8MT75, P51522, Q3ZCX0, Q6PI08
    Conserved Domains (2) summary
    COG5048
    Location:117 → 507
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:263 → 283
    ZF_C2H2; C2H2 Zn finger [structural motif]

  15. NM_001348018.2 → NP_001334947.1  zinc finger protein 83

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20) differs in the 5' UTR, compared to variant 1. All variants (1-5 and 10-21) encode the same protein.
    Source sequence(s)
    AA883993, AC022150, AK075066, BC013321, BG399319, DA258790, DA380756
    Consensus CDS
    CCDS12854.1
    UniProtKB/Swiss-Prot
    A8MT75, P51522, Q3ZCX0, Q6PI08
    Conserved Domains (2) summary
    COG5048
    Location:117 → 507
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:263 → 283
    ZF_C2H2; C2H2 Zn finger [structural motif]

  16. NM_001348019.2 → NP_001334948.1  zinc finger protein 83

    Status: VALIDATED

    Description
    Transcript Variant: This variant (21) differs in the 5' UTR, compared to variant 1. All variants (1-5 and 10-21) encode the same protein.
    Source sequence(s)
    AA883993, AC022150, AK075066, BC013321, BG399319, DA258790, DA380756, DA701045, DT216882
    Consensus CDS
    CCDS12854.1
    UniProtKB/Swiss-Prot
    A8MT75, P51522, Q3ZCX0, Q6PI08
    Conserved Domains (2) summary
    COG5048
    Location:117 → 507
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:263 → 283
    ZF_C2H2; C2H2 Zn finger [structural motif]

  17. NM_018300.4 → NP_060770.3  zinc finger protein 83

    See identical proteins and their annotated locations for NP_060770.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. All variants (1-5 and 10-21) encode the same protein.
    Source sequence(s)
    AA883993, BG260506, BG741860, DA107683, DA183557, DB107467, DR761375
    Consensus CDS
    CCDS12854.1
    UniProtKB/Swiss-Prot
    A8MT75, P51522, Q3ZCX0, Q6PI08
    Related
    ENSP00000301096.3, ENST00000301096.8
    Conserved Domains (2) summary
    COG5048
    Location:117 → 507
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:263 → 283
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    52612377..52690496 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    55696827..55774933 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001105553.1: Suppressed sequence

    Description
    NM_001105553.1: This RefSeq was permanently suppressed because it contains a zinc finger repeat polymorphism, not distinct splicing variation, in its coding sequence.

  2. NM_001105554.1: Suppressed sequence

    Description
    NM_001105554.1: This RefSeq was permanently suppressed because it contains a zinc finger repeat polymorphism, not distinct splicing variation, in its coding sequence.

  3. NM_001242531.1: Suppressed sequence

    Description
    NM_001242531.1: This RefSeq was permanently suppressed because it contains a zinc finger repeat polymorphism, not distinct splicing variation, in its coding sequence.

  4. NM_001242538.1: Suppressed sequence

    Description
    NM_001242538.1: This RefSeq was permanently suppressed because it contains a zinc finger repeat polymorphism, not distinct splicing variation, in its coding sequence.

  5. NR_003936.1: Suppressed sequence

    Description
    NR_003936.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51522.3 GenPept UniProtKB/Swiss-Prot:P51522

Gene LinkOut

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