urad ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: uradprovided by ZNC
Official Full Name: ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070112-472
See related: Ensembl:ENSDARG00000071579 AllianceGenome:ZFIN:ZDB-GENE-070112-472
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: prhoxnb; zgc:158663
Summary: Enables 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity. Predicted to be involved in urate catabolic process. Predicted to act upstream of or within allantoin biosynthetic process and purine nucleobase metabolic process. Predicted to be located in peroxisome. Orthologous to human URAD (ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (21687276..21689146, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (21542102..21543972, complement)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase has a role in uric acid degradation [OHCU decarboxylase]
Title: The structure of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase provides insights into the mechanism of uric acid degradation.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within allantoin metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within purine nucleobase metabolic process	IEA Inferred from Electronic Annotation more info
involved_in urate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in urate catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase

Names: OHCU decarboxylase; parahox cluster neighbor; parahox neighbor

NP_001073641.1

EC 4.1.1.97

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.