dnajc10 DnaJ (Hsp40) homolog, subfamily C, member 10 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dnajc10provided by ZNC
Official Full Name: DnaJ (Hsp40) homolog, subfamily C, member 10provided by ZNC
Primary source: ZFIN:ZDB-GENE-070327-1
See related: Ensembl:ENSDARG00000074727 AllianceGenome:ZFIN:ZDB-GENE-070327-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:162218
Summary: Predicted to enable misfolded protein binding activity; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor; and protein-disulfide reductase activity. Predicted to be involved in IRE1-mediated unfolded protein response. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum lumen. Orthologous to human DNAJC10 (DnaJ heat shock protein family (Hsp40) member C10). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (44870459..44897503, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (45069507..45096551, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fa01b05.s1 (e-PCR)
- UniSTS:189478

fc73b12.x1 (e-PCR)
- UniSTS:194386

fd05b02.y1 (e-PCR)
- UniSTS:194946

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables misfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	IBA Inferred from Biological aspect of Ancestor more info
enables protein-disulfide reductase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in IRE1-mediated unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum lumen	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dnaJ homolog subfamily C member 10

NP_001077016.1

EC 1.8.4.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083547.1 → NP_001077016.1 dnaJ homolog subfamily C member 10

See identical proteins and their annotated locations for NP_001077016.1

Status: PROVISIONAL

Source sequence(s)

BC134925

UniProtKB/TrEMBL

A0A8M1NCC7, A4IG47

Related

ENSDARP00000103524.2, ENSDART00000110697.3

Conserved Domains (7) summary

COG0484
Location:33 → 129

DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

cd02961
Location:348 → 443

PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...

cd03003
Location:128 → 228

PDI_a_ERdj5_N; PDIa family, N-terminal ERdj5 subfamily; ERdj5, also known as JPDI and macrothioredoxin, is a protein containing an N-terminal DnaJ domain and four redox active TRX domains. This subfamily is comprised of the first TRX domain of ERdj5 located after the ...

cd03004
Location:552 → 660

PDI_a_ERdj5_C; PDIa family, C-terminal ERdj5 subfamily; ERdj5, also known as JPDI and macrothioredoxin, is a protein containing an N-terminal DnaJ domain and four redox active TRX domains. This subfamily is composed of the three TRX domains located at the C-terminal ...

TIGR01130
Location:129 → 648

ER_PDI_fam; protein disulfide isomerase, eukaryotic

pfam00226
Location:33 → 95

DnaJ; DnaJ domain

cl00388
Location:276 → 318

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold