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ash2l ash2 like, histone lysine methyltransferase complex subunit [ Danio rerio (zebrafish) ]

Gene ID: 558193, updated on 2-Nov-2024

Summary

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Official Symbol
ash2lprovided by ZNC
Official Full Name
ash2 like, histone lysine methyltransferase complex subunitprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-494
See related
Ensembl:ENSDARG00000060392 AllianceGenome:ZFIN:ZDB-GENE-030131-494
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb34c06; fe38b04; fi20h02; wu:fb34c06; wu:fe38b04; wu:fi20h02; zgc:171444
Summary
Predicted to enable transcription cis-regulatory region binding activity. Acts upstream of or within hematopoietic progenitor cell differentiation and primitive erythrocyte differentiation. Predicted to be located in nucleus. Predicted to be part of Set1C/COMPASS complex. Orthologous to human ASH2L (ASH2 like, histone lysine methyltransferase complex subunit). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See ash2l in Genome Data Viewer
Location:
chromosome: 10
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (2758825..2788702, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (2731654..2761549, complement)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene mesoderm induction early response 1, family member 3 a Neighboring gene G protein-coupled receptor kinase 5 Neighboring gene posterior neuron-specific homeobox Neighboring gene AE binding protein 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Efficient mutagenesis by Cas9 protein-mediated oligonucleotide insertion and large-scale assessment of single-guide RNAs. Gagnon JA, et al. PLoS One, 2014. PMID 24873830, Free PMC Article
  2. PTC-bearing mRNA elicits a genetic compensation response via Upf3a and COMPASS components. Ma Z, et al. Nature, 2019 Apr. PMID 30944473
  3. Efficient identification of CRISPR/Cas9-induced insertions/deletions by direct germline screening in zebrafish. Brocal I, et al. BMC Genomics, 2016 Mar 24. PMID 27009152, Free PMC Article
  4. The Kdm/Kmt gene families in the self-fertilizing mangrove rivulus fish, Kryptolebias marmoratus, suggest involvement of histone methylation machinery in development and reproduction. Fellous A, et al. Gene, 2019 Mar 1. PMID 30458291
  5. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within primitive erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Set1C/COMPASS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Set1C/COMPASS complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
set1/Ash2 histone methyltransferase complex subunit ASH2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110105.2 → NP_001103575.2  set1/Ash2 histone methyltransferase complex subunit ASH2

    Status: VALIDATED

    Source sequence(s)
    CT027796, CT627023, CT679794, CT679795, CT698001
    UniProtKB/TrEMBL
    A0A8M1NG69, F1RAW8
    Related
    ENSDARP00000079466.4, ENSDART00000085031.6
    Conserved Domains (2) summary
    cd15583
    Location:58 → 103
    PHD_ash2p_like; PHD finger found in Schizosaccharomyces pombe Set1 complex component ash2 (spAsh2p) and similar proteins
    cd12872
    Location:354 → 545
    SPRY_Ash2; SPRY domain in Ash2

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    2758825..2788702 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005155525.5 → XP_005155582.1  set1/Ash2 histone methyltransferase complex subunit ASH2 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B2E1
    Conserved Domains (2) summary
    cd15583
    Location:58 → 103
    PHD_ash2p_like; PHD finger found in Schizosaccharomyces pombe Set1 complex component ash2 (spAsh2p) and similar proteins
    cd12872
    Location:348 → 539
    SPRY_Ash2; SPRY domain in Ash2
Nucleotide Protein Strain
Heading Accession and Version

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