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cdc42ep5 CDC42 effector protein (Rho GTPase binding) 5 [ Danio rerio (zebrafish) ]

Gene ID: 558275, updated on 2-Nov-2024

Summary

Official Symbol
cdc42ep5provided by ZNC
Official Full Name
CDC42 effector protein (Rho GTPase binding) 5provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5813
See related
Ensembl:ENSDARG00000062390 AllianceGenome:ZFIN:ZDB-GENE-030131-5813
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fi19g04; zgc:153966
Summary
Predicted to enable small GTPase binding activity. Predicted to be involved in Rho protein signal transduction; positive regulation of cellular component biogenesis; and regulation of cell shape. Predicted to be located in endomembrane system. Predicted to be active in cytoplasm; cytoskeleton; and plasma membrane. Is expressed in artery; cardiovascular system; notochord; pharyngeal arch; and polster. Orthologous to human CDC42EP5 (CDC42 effector protein 5). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See cdc42ep5 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (13875779..13881156, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (13985659..13991036, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene zgc:174888 Neighboring gene glutamate-rich WD repeat containing 1 Neighboring gene si:ch211-149k23.9 Neighboring gene ATG12 autophagy related 12 homolog (S. cerevisiae)

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Clone Names

  • MGC153966

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of pseudopodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045846.2NP_001039311.2  cdc42 effector protein 5

    Status: VALIDATED

    Source sequence(s)
    CU459065, EH453384
    UniProtKB/TrEMBL
    A0A8M1N9N1, F1R2T1
    Related
    ENSDARP00000084654.5, ENSDART00000090221.7
    Conserved Domains (2) summary
    pfam14957
    Location:85119
    BORG_CEP; Cdc42 effector
    cl00113
    Location:1643
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
  2. NM_001326377.1NP_001313306.1  cdc42 effector protein 5

    Status: VALIDATED

    Source sequence(s)
    CU459065
    UniProtKB/TrEMBL
    A0A8M1N9N1, F1R2T1
    Conserved Domains (2) summary
    pfam14957
    Location:85119
    BORG_CEP; Cdc42 effector
    cl00113
    Location:1643
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    13875779..13881156 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021466707.2XP_021322382.1  cdc42 effector protein 5 isoform X1

    UniProtKB/TrEMBL
    A0A8M1N9N1, F1R2T1
    Related
    ENSDARP00000120063.1, ENSDART00000138904.2
    Conserved Domains (2) summary
    pfam14957
    Location:85119
    BORG_CEP; Cdc42 effector
    cl00113
    Location:1643
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394957.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    397279..402656 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)