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kank3 KN motif and ankyrin repeat domains 3 [ Danio rerio (zebrafish) ]

Gene ID: 558407, updated on 2-Nov-2024

Summary

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Official Symbol
kank3provided by ZNC
Official Full Name
KN motif and ankyrin repeat domains 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-081105-185
See related
Ensembl:ENSDARG00000076566 AllianceGenome:ZFIN:ZDB-GENE-081105-185
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkeyp-104h9.6
Summary
Predicted to be involved in negative regulation of actin filament polymerization. Predicted to be active in cytoplasm and cytoskeleton. Is expressed in several structures, including dorsal fin fold; fin bud; gut; neural tube; and vasculature. Orthologous to human KANK3 (KN motif and ankyrin repeat domains 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See kank3 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (47755126..47818358, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (47769629..47811762, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene dipeptidyl-peptidase 9 Neighboring gene si:ch211-243p7.3 Neighboring gene si:dkeyp-104h9.5 Neighboring gene NADH:ubiquinone oxidoreductase subunit A7 Neighboring gene Pim proto-oncogene, serine/threonine kinase, related 185 Neighboring gene procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. NBP, a zebrafish homolog of human Kank3, is a novel Numb interactor essential for epidermal integrity and neurulation. Boggetti B, et al. Dev Biol, 2012 May 1. PMID 22387208
  2. Evolutionary and developmental analysis reveals KANK genes were co-opted for vertebrate vascular development. Hensley MR, et al. Sci Rep, 2016 Jun 13. PMID 27292017, Free PMC Article
  3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a possible role of NBP in establishing and maintaining cell adhesion and tissue integrity during gastrulation and later in development
    Title: NBP, a zebrafish homolog of human Kank3, is a novel Numb interactor essential for epidermal integrity and neurulation.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in negative regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
KN motif and ankyrin repeat domain-containing protein 3
Names
NBP
Numb-Binding Protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001257149.1 → NP_001244078.1  KN motif and ankyrin repeat domain-containing protein 3

    See identical proteins and their annotated locations for NP_001244078.1

    Status: PROVISIONAL

    Source sequence(s)
    HM151973
    UniProtKB/TrEMBL
    G3CES3
    Related
    ENSDARP00000098697.2, ENSDART00000115050.4
    Conserved Domains (5) summary
    cd00204
    Location:718 → 849
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12075
    Location:31 → 68
    KN_motif; KN motif
    pfam12796
    Location:728 → 826
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:815 → 870
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:723 → 755
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    47755126..47818358 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068222975.1 → XP_068079076.1  KN motif and ankyrin repeat domain-containing protein 3 isoform X1

Nucleotide Protein
Heading Accession and Version

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