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zp2l2 zona pellucida glycoprotein 2, like 2 [ Danio rerio (zebrafish) ]

Gene ID: 559251, updated on 4-Jan-2025

Summary

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Official Symbol
zp2l2provided by ZNC
Official Full Name
zona pellucida glycoprotein 2, like 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-060818-4
See related
Ensembl:ENSDARG00000004898 AllianceGenome:ZFIN:ZDB-GENE-060818-4
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zp2v2; zpb2c; zgc:162961
Summary
Predicted to enable acrosin binding activity. Predicted to be a structural constituent of egg coat. Predicted to be involved in binding activity of sperm to zona pellucida and prevention of polyspermy. Predicted to act upstream of or within single fertilization. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in collagen-containing extracellular matrix and egg coat. Orthologous to human ZP4 (zona pellucida glycoprotein 4). [provided by Alliance of Genome Resources, Jan 2025]
Annotation information
Annotation category: suggests misassembly
Annotation category: partial on reference assembly
Orthologs
all
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Genomic context

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See zp2l2 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (9945317..9952103, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (9709778..9716564, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 237b Neighboring gene serine/threonine-protein kinase pim-1-like Neighboring gene cytochrome P450, family 20, subfamily A, polypeptide 1 Neighboring gene abl-interactor 2b Neighboring gene integral membrane protein 2Ba

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Tandem-repeated Zebrafish zp3 genes possess oocyte-specific promoters and are insensitive to estrogen induction. Liu X, et al. Biol Reprod, 2006 Jun. PMID 16481590
  2. Bioinformatic analyses of zona pellucida genes in vertebrates and their expression in Nile tilapia. Wu T, et al. Fish Physiol Biochem, 2018 Apr. PMID 29307115
  3. The Ahr2-Dependent wfikkn1 Gene Influences Zebrafish Transcriptome, Proteome, and Behavior. Shankar P, et al. Toxicol Sci, 2022 May 26. PMID 35377459, Free PMC Article
  4. Early depletion of primordial germ cells in zebrafish promotes testis formation. Tzung KW, et al. Stem Cell Reports, 2015 Jan 13. PMID 25434820, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC162961

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables acrosin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of egg coat IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in binding of sperm to zona pellucida IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in prevention of polyspermy IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within single fertilization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in egg coat IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zona pellucida glycoprotein 2, like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001089502.1 → NP_001082971.1  zona pellucida glycoprotein 2, like 2 precursor

    See identical proteins and their annotated locations for NP_001082971.1

    Status: PROVISIONAL

    Source sequence(s)
    BC134168
    UniProtKB/TrEMBL
    A3KP56
    Related
    ENSDARP00000065474.5, ENSDART00000065475.6
    Conserved Domains (3) summary
    smart00018
    Location:67 → 107
    PD; P or trefoil or TFF domain
    smart00241
    Location:110 → 390
    ZP; Zona pellucida (ZP) domain
    pfam00100
    Location:262 → 389
    Zona_pellucida; Zona pellucida-like domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    9945317..9952103 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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