vtg1 vitellogenin 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: vtg1provided by ZNC
Official Full Name: vitellogenin 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-001201-1
See related: Ensembl:ENSDARG00000092233 AllianceGenome:ZFIN:ZDB-GENE-001201-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: vg1; zfvg1; wu:fb63b05; wu:fb66b04; zgc:109796
Summary: Enables antioxidant activity. Acts upstream of or within several processes, including cellular response to estrogen stimulus; hatching; and response to estradiol. Is expressed in several structures, including adipose tissue; atrium; liver; pleuroperitoneal region; and unfertilized egg. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 22

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (24731160..24738189, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (24703341..24710583, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Here the authors report that zebrafish embryos without maternally provided vg1 fail to form endoderm and head and trunk mesoderm, and closely resemble nodal loss-of-function mutants. Although Nodal is processed and secreted without Vg1, it requires Vg1 for its endogenous activity.
Title: Vg1-Nodal heterodimers are the endogenous inducers of mesendoderm.
the performance of the immunosensor in detecting Vtg was evaluated by quantifying Vtg induction in juvenile zebrafish exposed to 17beta-estradiol (E2). Compared with conventional immunoassay techniques, the Vtg immunosensor developed based on the Octet system was much simpler and less time-consuming, allowing rapid Vtg quantification within 15 min.
Title: Development of an immunosensor for quantifying zebrafish vitellogenin based on the Octet system.
Hepatic vtg 1A/B gene expression was upregulated 3.89-fold 1-h postspawning relative to the average gene expression across all time points, but was not correlated to stage-specific oogenesis.
Title: Temporal dynamics of oocyte growth and vitellogenin gene expression in zebrafish (Danio rerio).
differences in methylation levels of the vitellogenin I gene related to sex, tissue and exposure to estrogen
Title: DNA methylation levels in the 5' flanking region of the vitellogenin I gene in liver and brain of adult zebrafish (Danio rerio)--sex and tissue differences and effects of 17alpha-ethinylestradiol exposure.
Data show that temperature and photoperiod significantly influence the transcription of the estrogen-responsive genes, Vtg1, Vtg2, ER alpha and ER beta after a 21-day exposure to endocrine-disrupting chemicals.
Title: Temperature and photoperiod affect the endocrine disruption effects of ethinylestradiol, nonylphenol and their binary mixture in zebrafish (Danio rerio).
Toxicant-induced disturbance of Vtg degradation processes during Danio rerio (DR) embryogenesis was analysed.
Title: Vitellogenin cleavage products as indicators for toxic stress in zebra fish embryos: a proteomic approach.
Vitellogenin 1 is specifically expressed in female liver and can be induced by 17beta-estradiol (E2) in male fish both by intramuscular injection and immersion treatment.
Title: Molecular cloning of zebrafish and medaka vitellogenin genes and comparison of their expression in response to 17beta-estradiol.

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General gene information

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Markers

AI497034 (e-PCR)
- UniSTS:206373

AA566636 (e-PCR)
- UniSTS:206895

fd55c06.x1 (e-PCR)
- UniSTS:195654

fd55e03.x1 (e-PCR)
- UniSTS:195663

fd55g08.x1 (e-PCR)
- UniSTS:195666

fb63b05 (e-PCR)
- UniSTS:189034

fb59e10 (e-PCR)
- UniSTS:187267

fb65b06 (e-PCR)
- UniSTS:189065

fb67a10 (e-PCR)
- UniSTS:189069

fb63d10.y1 (e-PCR)
- UniSTS:203407

fi31h09.x1 (e-PCR)
- UniSTS:197268

fb68e07 (e-PCR), detects polymorphism
- UniSTS:189087

fb62f05 (e-PCR)
- UniSTS:187317

fb66b04 (e-PCR)
- UniSTS:187326

fb66b04.x1 (e-PCR)
- UniSTS:190918

fb67c12.x1 (e-PCR)
- UniSTS:190952

fi49a01.x1 (e-PCR)
- UniSTS:197631

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables antioxidant activity	IDA Inferred from Direct Assay more info	PubMed
enables lipid transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables lipid transporter activity	IEA Inferred from Electronic Annotation more info
enables nutrient reservoir activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to estrogen stimulus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to estrogen stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within hatching	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
involved_in response to estradiol	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to estradiol	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: vitellogenin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044897.3 → NP_001038362.3 vitellogenin 1 precursor

Status: VALIDATED

Source sequence(s)

AI585028, BX539332, EB876123, EB876683, EB881345, EH489594, EH492388, EH506270, EH509645, EH525498, EH528046, EH535710

UniProtKB/TrEMBL

A0A8M1N9G0, Q1LWN2

Conserved Domains (3) summary

pfam01347
Location:24 → 592

Vitellogenin_N; Lipoprotein amino terminal region

pfam09172
Location:626 → 917

DUF1943; Domain of unknown function (DUF1943)

pfam09175
Location:1168 → 1332

DUF1944; Domain of unknown function (DUF1944)