U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mrtfab myocardin related transcription factor Ab [ Danio rerio (zebrafish) ]

Gene ID: 559638, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
mrtfabprovided by ZNC
Official Full Name
myocardin related transcription factor Abprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-681
See related
Ensembl:ENSDARG00000076229 AllianceGenome:ZFIN:ZDB-GENE-030131-681
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
mkl1b; fb39e12; wu:fb39e12
Summary
Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and smooth muscle cell differentiation. Predicted to be active in nucleus. Is expressed in heart. Human ortholog(s) of this gene implicated in acute megakaryocytic leukemia and immunodeficiency 66. Orthologous to human MRTFA (myocardin related transcription factor A). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See mrtfab in Genome Data Viewer
Location:
chromosome: 12
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (18718133..18787317)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (18596321..18665443)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene serine/threonine-protein kinase pim-2-like Neighboring gene regulator of G protein signaling 9b Neighboring gene shisa family member 8b Neighboring gene desumoylating isopeptidase 1b

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Ablation of Mto1 in zebrafish exhibited hypertrophic cardiomyopathy manifested by mitochondrion RNA maturation deficiency. Zhang Q, et al. Nucleic Acids Res, 2021 May 7. PMID 33836087, Free PMC Article
  2. Protein kinase C family evolution in jawed vertebrates. Garcia-Concejo A, et al. Dev Biol, 2021 Nov. PMID 34329618
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in smooth muscle cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
myocardin related transcription factor Ab
Names
megakaryoblastic leukemia (translocation) 1b

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001201558.1 → NP_001188487.1  myocardin related transcription factor Ab

    See identical proteins and their annotated locations for NP_001188487.1

    Status: VALIDATED

    Source sequence(s)
    AL772266, CU571387
    UniProtKB/TrEMBL
    A0A8M1P1Q1, E7F9J6
    Related
    ENSDARP00000127385.1, ENSDART00000152935.3
    Conserved Domains (3) summary
    smart00707
    Location:85 → 110
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02037
    Location:385 → 418
    SAP; SAP domain
    pfam02755
    Location:131 → 151
    RPEL; RPEL repeat

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    18718133..18787317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021480117.2 → XP_021335792.1  myocardin related transcription factor Ab isoform X2

    UniProtKB/TrEMBL
    A0A8M9Q8G2
    Conserved Domains (5) summary
    smart00707
    Location:85 → 109
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02037
    Location:400 → 433
    SAP; SAP domain
    pfam02755
    Location:146 → 166
    RPEL; RPEL repeat
    cl17044
    Location:591 → 623
    DD_cGKI; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I
    cl27333
    Location:361 → 437
    PARP_reg; Poly(ADP-ribose) polymerase, regulatory domain

  2. XM_021480118.2 → XP_021335793.1  myocardin related transcription factor Ab isoform X2

    UniProtKB/TrEMBL
    A0A8M9Q8G2
    Conserved Domains (5) summary
    smart00707
    Location:85 → 109
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02037
    Location:400 → 433
    SAP; SAP domain
    pfam02755
    Location:146 → 166
    RPEL; RPEL repeat
    cl17044
    Location:591 → 623
    DD_cGKI; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I
    cl27333
    Location:361 → 437
    PARP_reg; Poly(ADP-ribose) polymerase, regulatory domain

  3. XM_021480121.2 → XP_021335796.1  myocardin related transcription factor Ab isoform X6

    UniProtKB/TrEMBL
    A0A8M9QIS0
    Conserved Domains (5) summary
    smart00707
    Location:5 → 30
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02037
    Location:364 → 397
    SAP; SAP domain
    pfam02755
    Location:110 → 130
    RPEL; RPEL repeat
    cl17044
    Location:555 → 587
    DD_cGKI; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I
    cl27333
    Location:325 → 401
    PARP_reg; Poly(ADP-ribose) polymerase, regulatory domain

  4. XM_021480116.2 → XP_021335791.1  myocardin related transcription factor Ab isoform X1

    UniProtKB/TrEMBL
    A0A8M9QIR6
    Conserved Domains (5) summary
    smart00707
    Location:87 → 111
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02037
    Location:402 → 435
    SAP; SAP domain
    pfam02755
    Location:148 → 168
    RPEL; RPEL repeat
    cl17044
    Location:593 → 625
    DD_cGKI; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I
    cl27333
    Location:363 → 439
    PARP_reg; Poly(ADP-ribose) polymerase, regulatory domain

  5. XM_021480120.2 → XP_021335795.1  myocardin related transcription factor Ab isoform X5

    UniProtKB/TrEMBL
    A0A8M9QMJ6
    Conserved Domains (4) summary
    smart00707
    Location:87 → 111
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02037
    Location:402 → 435
    SAP; SAP domain
    pfam02755
    Location:148 → 168
    RPEL; RPEL repeat
    cl27333
    Location:363 → 439
    PARP_reg; Poly(ADP-ribose) polymerase, regulatory domain

  6. XM_021480119.2 → XP_021335794.1  myocardin related transcription factor Ab isoform X3

    UniProtKB/TrEMBL
    A0A8M9QEC1
    Conserved Domains (5) summary
    smart00707
    Location:87 → 111
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02037
    Location:398 → 431
    SAP; SAP domain
    pfam02755
    Location:148 → 168
    RPEL; RPEL repeat
    cl17044
    Location:589 → 621
    DD_cGKI; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I
    cl27333
    Location:359 → 435
    PARP_reg; Poly(ADP-ribose) polymerase, regulatory domain

  7. XM_005156147.5 → XP_005156204.1  myocardin related transcription factor Ab isoform X4

    UniProtKB/TrEMBL
    A0A8M2B2H4
    Conserved Domains (3) summary
    smart00707
    Location:87 → 112
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02037
    Location:387 → 420
    SAP; SAP domain
    pfam02755
    Location:133 → 153
    RPEL; RPEL repeat

  8. XM_068224603.1 → XP_068080704.1  myocardin related transcription factor Ab isoform X7

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394835.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    710918..781418
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools