U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

tox4a TOX high mobility group box family member 4 a [ Danio rerio (zebrafish) ]

Gene ID: 559853, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
tox4aprovided by ZNC
Official Full Name
TOX high mobility group box family member 4 aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070912-576
See related
Ensembl:ENSDARG00000002031 AllianceGenome:ZFIN:ZDB-GENE-070912-576
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
tox4; wu:fe15b11; si:dkey-75g22.1
Summary
Predicted to enable chromatin DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in telencephalon. Orthologous to human TOX4 (TOX high mobility group box family member 4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See tox4a in Genome Data Viewer
Location:
chromosome: 2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (38067510..38080656, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (38085347..38098528, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene calsequestrin 1a Neighboring gene si:rp71-1g18.1 Neighboring gene chromodomain helicase DNA binding protein 8 Neighboring gene cerebellin 12

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Characterization of γδ T Cells from Zebrafish Provides Insights into Their Important Role in Adaptive Humoral Immunity. Wan F, et al. Front Immunol, 2016. PMID 28119690, Free PMC Article
  2. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
  3. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • KIAA0737

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
TOX high mobility group box family member 4-A; epidermal Langerhans cell protein LCP1-like

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    38067510..38080656 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001920966.8 → XP_001921001.2  TOX high mobility group box family member 4-A

    UniProtKB/TrEMBL
    A0A8M1QLB8, F1QXS5
    Related
    ENSDARP00000056543.6, ENSDART00000056544.7
    Conserved Domains (2) summary
    PHA03369
    Location:215 → 510
    PHA03369; capsid maturational protease; Provisional
    cd00084
    Location:300 → 365
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394506.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    110376..123522 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021471257.2 → XP_021326932.1  TOX high mobility group box family member 4-A

    UniProtKB/TrEMBL
    A0A8M1QLB8, F1QXS5
    Conserved Domains (2) summary
    PHA03369
    Location:215 → 510
    PHA03369; capsid maturational protease; Provisional
    cd00084
    Location:300 → 365
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.