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arhgef28a Rho guanine nucleotide exchange factor (GEF) 28a [ Danio rerio (zebrafish) ]

Gene ID: 559941, updated on 4-Jan-2025

Summary

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Official Symbol
arhgef28aprovided by ZNC
Official Full Name
Rho guanine nucleotide exchange factor (GEF) 28aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060531-28
See related
Ensembl:ENSDARG00000060415 AllianceGenome:ZFIN:ZDB-GENE-060531-28
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
rgnef; arhgef28; p190RhoGEF; si:ch211-1o14.5
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and metal ion binding activity. Acts upstream of or within Golgi organization; cell-matrix adhesion; and muscle tissue morphogenesis. Predicted to be located in cytoplasm. Is expressed in ball; head; notochord; somite; and trunk. Orthologous to human ARHGEF28 (Rho guanine nucleotide exchange factor 28). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See arhgef28a in Genome Data Viewer
Location:
chromosome: 5
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (34829723..34964822, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (34229423..34364648, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene ectodermal-neural cortex 1 Neighboring gene uncharacterized LOC137495608 Neighboring gene ankyrin repeat, family A (RFXANK-like), 2 Neighboring gene basic transcription factor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification of novel MYO18A interaction partners required for myoblast adhesion and muscle integrity. Cao JM, et al. Sci Rep, 2016 Nov 8. PMID 27824130, Free PMC Article
  2. Transcriptome analysis reveals positive selection on the divergent between topmouth culter and zebrafish. Ren L, et al. Gene, 2014 Dec 1. PMID 25267534
  3. The guanine nucleotide exchange factor Net1 facilitates the specification of dorsal cell fates in zebrafish embryos by promoting maternal β-catenin activation. Wei S, et al. Cell Res, 2017 Feb. PMID 27910850, Free PMC Article
  4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Golgi organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within muscle tissue morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within muscle tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rho-guanine nucleotide exchange factor; rho guanine nucleotide exchange factor 28
Names
Rho guanine nucleotide exchange factor (GEF) 28
Rho-guanine nucleotide exchange factor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    34829723..34964822 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068221454.1 → XP_068077555.1  rho guanine nucleotide exchange factor 28 isoform X3

    UniProtKB/TrEMBL
    A0A8M9PL62

  2. XM_021476534.2 → XP_021332209.1  rho guanine nucleotide exchange factor 28 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PL62, A0A8M9Q486, F6P6M2
    Related
    ENSDARP00000116715.2, ENSDART00000133170.3
    Conserved Domains (4) summary
    cd00029
    Location:716 → 761
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:910 → 1104
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00204
    Location:229 → 283
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14680
    Location:1148 → 1248
    PH_p190RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain

  3. XM_021476533.2 → XP_021332208.1  rho guanine nucleotide exchange factor 28 isoform X4

    UniProtKB/TrEMBL
    A0A8M6YZA7, A0A8M9PYS9
    Conserved Domains (4) summary
    cd00029
    Location:745 → 790
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:939 → 1133
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00204
    Location:229 → 283
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14680
    Location:1177 → 1277
    PH_p190RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain

  4. XM_021476529.2 → XP_021332204.1  rho guanine nucleotide exchange factor 28 isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q483, A0A8M9QEQ0
    Conserved Domains (4) summary
    cd00029
    Location:779 → 824
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:973 → 1167
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00204
    Location:229 → 283
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14680
    Location:1211 → 1311
    PH_p190RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394590.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    139078..276236 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068218239.1 → XP_068074340.1  rho guanine nucleotide exchange factor 28 isoform X3

    UniProtKB/TrEMBL
    A0A8M6YZA7

  2. XM_068218238.1 → XP_068074339.1  rho guanine nucleotide exchange factor 28 isoform X7

    UniProtKB/TrEMBL
    A0A8M9PL62

  3. XM_009301598.4 → XP_009299873.2  rho guanine nucleotide exchange factor 28 isoform X5

    UniProtKB/TrEMBL
    A0A8M3ASG5, A0A8M9QEQ0
    Conserved Domains (4) summary
    cd00029
    Location:772 → 817
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:966 → 1160
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00204
    Location:229 → 283
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14680
    Location:1204 → 1304
    PH_p190RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain

  4. XM_017356272.3 → XP_017211761.2  rho guanine nucleotide exchange factor 28 isoform X2

    UniProtKB/TrEMBL
    A0A8M6YZA7, A0A8M6Z0T3
    Conserved Domains (4) summary
    cd00029
    Location:716 → 761
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:910 → 1104
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00204
    Location:229 → 283
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14680
    Location:1148 → 1248
    PH_p190RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain

  5. XM_017356270.3 → XP_017211759.2  rho guanine nucleotide exchange factor 28 isoform X6

    UniProtKB/TrEMBL
    A0A8M6Z6H3, A0A8M9PL62
    Conserved Domains (4) summary
    cd00029
    Location:750 → 795
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:944 → 1138
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00204
    Location:229 → 283
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14680
    Location:1182 → 1282
    PH_p190RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain

  6. XM_017356269.3 → XP_017211758.2  rho guanine nucleotide exchange factor 28 isoform X1

    UniProtKB/TrEMBL
    A0A8M6YYE7, A0A8M9QEQ0
    Conserved Domains (4) summary
    cd00029
    Location:779 → 824
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:973 → 1167
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00204
    Location:229 → 283
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14680
    Location:1211 → 1311
    PH_p190RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain
Nucleotide Protein Strain
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