dsc2l desmocollin 2 like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dsc2lprovided by ZNC
Official Full Name: desmocollin 2 likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-031116-55
See related: Ensembl:ENSDARG00000039677 AllianceGenome:ZFIN:ZDB-GENE-031116-55
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dsc; sb:cb859; wu:fa94h05
Summary: Predicted to enable calcium ion binding activity. Involved in heart contraction and heart morphogenesis. Acts upstream of or within desmosome assembly; gastrulation; and heart development. Predicted to be located in anchoring junction and plasma membrane. Predicted to be active in desmosome. Is expressed in several structures, including EVL; cardiovascular system; ectoderm; peripheral olfactory organ; and pronephric duct. Used to study arrhythmogenic right ventricular cardiomyopathy. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy and arrhythmogenic right ventricular dysplasia 11. Orthologous to human DSC1 (desmocollin 1); DSC2 (desmocollin 2); and DSC3 (desmocollin 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (7263856..7293836, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (7273977..7303957, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

zebrafish possess one Dsc, the orthologue of mammalian Dsc1, which we designate zfDsc.
Title: Desmosomal cadherins in zebrafish epiboly and gastrulation.

Submit: New GeneRIF Correction

General gene information

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Markers

G45438 (e-PCR)
- UniSTS:106240

fk94e02.x1 (e-PCR)
- UniSTS:201763

fa94h05 (e-PCR)
- UniSTS:188888

fj15f07.x1 (e-PCR)
- UniSTS:198620

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within convergent extension involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within desmosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epiboly involved in gastrulation with mouth forming second	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
is_active_in desmosome	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: desmocollin 2-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001287083.1 → NP_001274012.1 desmocollin 2-like protein

Status: PROVISIONAL

Source sequence(s)

JQ013460

UniProtKB/Swiss-Prot

A0A8M1P697, B3DLJ9, F1QSQ0, H2EQR5, Q08BK3

Related

ENSDARP00000090832.4, ENSDART00000100060.5

Conserved Domains (4) summary

cd11304
Location:279 → 377

Cadherin_repeat; Cadherin tandem repeat domain

smart01055
Location:66 → 140

Cadherin_pro; Cadherin prodomain like

pfam01049
Location:861 → 925

Cadherin_C; Cadherin cytoplasmic region

cl09101
Location:619 → 690

E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus