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Lgals8 lectin, galactose binding, soluble 8 [ Mus musculus (house mouse) ]

Gene ID: 56048, updated on 9-Dec-2024

Summary

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Official Symbol
Lgals8provided by MGI
Official Full Name
lectin, galactose binding, soluble 8provided by MGI
Primary source
MGI:MGI:1928481
See related
Ensembl:ENSMUSG00000057554 AllianceGenome:MGI:1928481
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lgals-8; D13Ertd524e; 1200015E08Rik
Summary
Enables carbohydrate binding activity. Acts upstream of or within T cell costimulation and plasma cell differentiation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human LGALS8 (galectin 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in testis adult (RPKM 33.3), bladder adult (RPKM 18.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Lgals8 in Genome Data Viewer
Location:
13 A1; 13 4.64 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (12454283..12479857, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (12439402..12464977, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5445 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:12487435-12487618 Neighboring gene HEAT repeat containing 1 Neighboring gene predicted gene 5928 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:12552850-12553003 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:12553416-12553525 Neighboring gene STARR-positive B cell enhancer ABC_E5367 Neighboring gene EDAR associated via death domain Neighboring gene VISTA enhancer mm1376 Neighboring gene predicted gene, 30239 Neighboring gene STARR-positive B cell enhancer ABC_E4051

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Galectin-8 Ameliorates Murine Autoimmune Ocular Pathology and Promotes a Regulatory T Cell Response. Sampson JF, et al. PLoS One, 2015. PMID 26126176, Free PMC Article
  2. Galectin-8 tandem-repeat structure is essential for T-cell proliferation but not for co-stimulation. Cattaneo V, et al. Biochem J, 2011 Feb 15. PMID 21091438
  3. Galectin-8 activates dendritic cells and stimulates antigen-specific immune response elicitation. Carabelli J, et al. J Leukoc Biol, 2017 Nov. PMID 28811319
  4. Ablation of the mammalian lectin galectin-8 induces bone defects in mice. Vinik Y, et al. FASEB J, 2018 May. PMID 29259034
  5. Characterization of a double-CRD-mutated Gal-8 recombinant protein that retains co-stimulatory activity on antigen-specific T-cell response. Schroeder MN, et al. Biochem J, 2016 Apr 1. PMID 26795039

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors.
    Title: Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors.
  2. Galectin-8 involves in arthritic condylar bone loss via podoplanin/AKT/ERK axis-mediated inflammatory lymphangiogenesis.
    Title: Galectin-8 involves in arthritic condylar bone loss via podoplanin/AKT/ERK axis-mediated inflammatory lymphangiogenesis.
  3. Galectin-8 Downmodulates TLR4 Activation and Impairs Bacterial Clearance in a Mouse Model of Pseudomonas aeruginosa Keratitis.
    Title: Galectin-8 Downmodulates TLR4 Activation and Impairs Bacterial Clearance in a Mouse Model of Pseudomonas aeruginosa Keratitis.
  4. Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages.
    Title: Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages.
  5. Anti-inflammatory Role of Galectin-8 During Trypanosoma cruzi Chronic Infection.
    Title: Anti-inflammatory Role of Galectin-8 During Trypanosoma cruzi Chronic Infection.
  6. The Animal Lectin Galectin-8 Promotes Cytokine Expression and Metastatic Tumor Growth in Mice.
    Title: The Animal Lectin Galectin-8 Promotes Cytokine Expression and Metastatic Tumor Growth in Mice.
  7. Gal-8 expression was reduced in CCl4-induced liver fibrosis model in mice suggesting that Gal-8 is a diagnostic and/or prognostic glycoprotein for liver fibrosis.
    Title: Ginger potentiates the effects of silymarin on liver fibrosis induced by CCL4: the role of galectin-8.
  8. these findings identify gal-8 as a new physiologic player in the regulation of bone mass.
    Title: Ablation of the mammalian lectin galectin-8 induces bone defects in mice.
  9. Galectin-8 regulates antibacterial autophagy through differential recognition of host glycans on damaged phagosomes.
    Title: Cytosolic galectin-3 and -8 regulate antibacterial autophagy through differential recognition of host glycans on damaged phagosomes.
  10. Galectin-8 activates dendritic cells and stimulates antigen-specific immune response elicitation.
    Title: Galectin-8 activates dendritic cells and stimulates antigen-specific immune response elicitation.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbohydrate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within T cell costimulation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to virus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lymphatic endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in lymphatic endothelial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within plasma cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in xenophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in xenophagy ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
galectin-8
Names
galectin-8L
lectin, galactose binding, soluble 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199043.1 → NP_001185972.1  galectin-8 isoform 1

    See identical proteins and their annotated locations for NP_001185972.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 3. Variants 1 and 2 encode the same isoform (1), which is shorter than isoform 2.
    Source sequence(s)
    AC154221, AK004782, BQ033229
    Consensus CDS
    CCDS36592.1
    UniProtKB/Swiss-Prot
    Q9JL15
    UniProtKB/TrEMBL
    Q3U2W5, Q542M5
    Related
    ENSMUSP00000097408.4, ENSMUST00000099820.10
    Conserved Domains (1) summary
    smart00908
    Location:24 → 148
    Gal-bind_lectin; Galactoside-binding lectin

  2. NM_001291055.1 → NP_001277984.1  galectin-8 isoform 2

    See identical proteins and their annotated locations for NP_001277984.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (2).
    Source sequence(s)
    AK075736, AK083350, CJ207511, EF524570
    Consensus CDS
    CCDS70431.1
    UniProtKB/TrEMBL
    A8DIL0, Q3U2W5
    Related
    ENSMUSP00000114200.2, ENSMUST00000144283.2
    Conserved Domains (1) summary
    smart00908
    Location:24 → 148
    Gal-bind_lectin; Galactoside-binding lectin

  3. NM_001291057.1 → NP_001277986.1  galectin-8 isoform 3

    See identical proteins and their annotated locations for NP_001277986.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, initiates translation at a downstream start codon and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. Variants 4 and 5 encode the same isoform (3), which is shorter than isoform 2.
    Source sequence(s)
    AC154221, AK075736, AK083350, CJ207511
    Consensus CDS
    CCDS70430.1
    UniProtKB/TrEMBL
    Q8C6H0
    Related
    ENSMUSP00000118925.2, ENSMUST00000143693.8
    Conserved Domains (1) summary
    smart00908
    Location:101 → 220
    Gal-bind_lectin; Galactoside-binding lectin

  4. NM_001291060.1 → NP_001277989.1  galectin-8 isoform 3

    See identical proteins and their annotated locations for NP_001277989.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding region, initiates translation at a downstream start codon and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. Variants 4 and 5 encode the same isoform (3), which is shorter than isoform 2.
    Source sequence(s)
    AC154221, AK075736, AK083350, CJ207511, EF524570
    Consensus CDS
    CCDS70430.1
    UniProtKB/TrEMBL
    Q8C6H0
    Related
    ENSMUSP00000120210.2, ENSMUST00000135166.8
    Conserved Domains (1) summary
    smart00908
    Location:101 → 220
    Gal-bind_lectin; Galactoside-binding lectin

  5. NM_018886.5 → NP_061374.1  galectin-8 isoform 1

    See identical proteins and their annotated locations for NP_061374.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 3. Variants 1 and 2 encode the same isoform (1), which is shorter than isoform 2.
    Source sequence(s)
    AC154221, AK004782, AK029526, BQ033229
    Consensus CDS
    CCDS36592.1
    UniProtKB/Swiss-Prot
    Q9JL15
    UniProtKB/TrEMBL
    Q3U2W5, Q542M5
    Related
    ENSMUSP00000097409.4, ENSMUST00000099821.10
    Conserved Domains (1) summary
    smart00908
    Location:24 → 148
    Gal-bind_lectin; Galactoside-binding lectin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    12454283..12479857 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158098.1 → XP_036013991.1  galectin-8 isoform X7

    Conserved Domains (1) summary
    smart00908
    Location:92 → 211
    Gal-bind_lectin; Galactoside-binding lectin

  2. XM_011244325.1 → XP_011242627.1  galectin-8 isoform X6

    See identical proteins and their annotated locations for XP_011242627.1

    UniProtKB/TrEMBL
    Q8C6H0
    Conserved Domains (1) summary
    smart00908
    Location:101 → 220
    Gal-bind_lectin; Galactoside-binding lectin

  3. XM_017315547.1 → XP_017171036.1  galectin-8 isoform X4

    UniProtKB/TrEMBL
    Q3U2W5
    Conserved Domains (1) summary
    smart00908
    Location:24 → 148
    Gal-bind_lectin; Galactoside-binding lectin

  4. XM_006516715.2 → XP_006516778.1  galectin-8 isoform X2

    See identical proteins and their annotated locations for XP_006516778.1

    UniProtKB/Swiss-Prot
    Q9JL15
    UniProtKB/TrEMBL
    Q3U2W5, Q542M5
    Related
    ENSMUSP00000115094.2, ENSMUST00000124888.8
    Conserved Domains (1) summary
    smart00908
    Location:24 → 148
    Gal-bind_lectin; Galactoside-binding lectin

  5. XM_030247327.2 → XP_030103187.1  galectin-8 isoform X3

    UniProtKB/TrEMBL
    Q3U2W5
    Conserved Domains (1) summary
    smart00908
    Location:24 → 148
    Gal-bind_lectin; Galactoside-binding lectin

  6. XM_011244321.1 → XP_011242623.1  galectin-8 isoform X1

    See identical proteins and their annotated locations for XP_011242623.1

    UniProtKB/TrEMBL
    A8DIL0, Q3U2W5
    Conserved Domains (1) summary
    smart00908
    Location:24 → 148
    Gal-bind_lectin; Galactoside-binding lectin

  7. XM_017315548.1 → XP_017171037.1  galectin-8 isoform X5

    Conserved Domains (1) summary
    smart00908
    Location:110 → 229
    Gal-bind_lectin; Galactoside-binding lectin

  8. XM_017315549.1 → XP_017171038.1  galectin-8 isoform X6

    UniProtKB/TrEMBL
    Q8C6H0
    Conserved Domains (1) summary
    smart00908
    Location:101 → 220
    Gal-bind_lectin; Galactoside-binding lectin

  9. XM_011244324.1 → XP_011242626.1  galectin-8 isoform X5

    Conserved Domains (1) summary
    smart00908
    Location:110 → 229
    Gal-bind_lectin; Galactoside-binding lectin

  10. XM_011244323.1 → XP_011242625.1  galectin-8 isoform X4

    UniProtKB/TrEMBL
    Q3U2W5
    Conserved Domains (1) summary
    smart00908
    Location:24 → 148
    Gal-bind_lectin; Galactoside-binding lectin

  11. XM_006516714.2 → XP_006516777.1  galectin-8 isoform X2

    See identical proteins and their annotated locations for XP_006516777.1

    UniProtKB/Swiss-Prot
    Q9JL15
    UniProtKB/TrEMBL
    Q3U2W5, Q542M5
    Conserved Domains (1) summary
    smart00908
    Location:24 → 148
    Gal-bind_lectin; Galactoside-binding lectin

  12. XM_011244322.3 → XP_011242624.1  galectin-8 isoform X3

    UniProtKB/TrEMBL
    Q3U2W5
    Conserved Domains (1) summary
    smart00908
    Location:24 → 148
    Gal-bind_lectin; Galactoside-binding lectin

  13. XM_011244320.1 → XP_011242622.1  galectin-8 isoform X1

    See identical proteins and their annotated locations for XP_011242622.1

    UniProtKB/TrEMBL
    A8DIL0, Q3U2W5
    Conserved Domains (1) summary
    smart00908
    Location:24 → 148
    Gal-bind_lectin; Galactoside-binding lectin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JL15.1 GenPept UniProtKB/Swiss-Prot:Q9JL15

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